Reactome | TJP1 [cytosol]

TJP1 [cytosol]

Stable Identifier

R-HSA-532659

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ZO-1, Tight junction protein 1, Zona occludens protein 1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q07157 TJP1

Gene Names

TJP1, ZO1

Chain

chain:1-1748

Reference Genes

BioGPS Gene:7082 TJP1

COSMIC (genes):TJP1 TJP1

CTD Gene:7082 TJP1

dbSNP Gene:7082 TJP1

ENSEMBL:ENSG00000104067 TJP1

HGNC:11827 TJP1

KEGG:hsa:7082 TJP1

Monarch:7082 TJP1

NCBI Gene:7082 TJP1

OMIM:601009 TJP1

UCSC:Q07157 TJP1

Reference Transcript

Other Identifiers

11725503_s_at

11754242_a_at

16806467

17121270

202011_PM_at

202011_at

214168_PM_s_at

214168_s_at

2402748

2496303

2618787

2816213

32532_at

3615594

3615595

3615596

3615597

3615600

3615601

3615603

3615604

3615605

3615607

3615608

3615609

3615610

3615612

3615613

3615614

3615616

3615618

3615619

3615624

3615625

3615626

3615627

3615628

3615629

3615630

3615631

3615632

3615634

3615635

3615636

3615638

3615639

3615640

3615650

3615651

3615652

3615653

3615654

3615657

3615658

3615659

3615660

3615669

3615670

3615671

3615678

3615679

3615681

3615682

3615683

3615684

3615685

3615686

3615703

3615705

3653814

7082

78685_at

7986977

A_23_P205828

A_24_P193435

GE81254

GO:0001825

GO:0002102

GO:0003013

GO:0005515

GO:0005516

GO:0005634

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0005911

GO:0005912

GO:0005921

GO:0005923

GO:0007010

GO:0007043

GO:0007155

GO:0007605

GO:0008013

GO:0008284

GO:0009410

GO:0014704

GO:0016020

GO:0016323

GO:0016324

GO:0016327

GO:0019904

GO:0030036

GO:0030054

GO:0030154

GO:0030335

GO:0031032

GO:0032496

GO:0032991

GO:0034330

GO:0034334

GO:0035633

GO:0036305

GO:0042995

GO:0043066

GO:0043116

GO:0043226

GO:0043296

GO:0044325

GO:0045177

GO:0045216

GO:0045296

GO:0045471

GO:0046581

GO:0048856

GO:0050839

GO:0050877

GO:0051493

GO:0051497

GO:0070160

GO:0071000

GO:0071253

GO:0071333

GO:0071896

GO:0090557

GO:0098609

GO:0150105

GO:1901888

GO:1902396

GO:1903672

GO:1905605

GO:2000049

GO:2000810

HMNXSV003050803

Hs.74614.1.S1_3p_a_at

ILMN_1691499

ILMN_2403006

L14837_at

PH_hs_0004256

TC15001110.hg

TC15002459.hg

g4507516_3p_at

Participates

as a component of

as an input of

Other forms of this molecule

TJP1 [Golgi-associated vesicle membrane]

TJP1 [plasma membrane]

TJP1 (?-?) [plasma membrane]

TJP1 [cell junction]

Inferred To

zoo-1 [cytosol] (Caenorhabditis elegans)

Tjp1 [cytosol] (Mus musculus)

Tjp1 [cytosol] (Rattus norvegicus)

TJP1 [cytosol] (Bos taurus)

TJP1 [cytosol] (Canis familiaris)

TJP1 [cytosol] (Gallus gallus)

TJP1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_783297.2, NP_003248.3

OpenTargets

ENSG00000104067

ENSEMBL

ENSP00000484535, ENST00000346128, ENST00000621049, ENSP00000441202, ENST00000545208, ENSP00000281537

HPA

ENSG00000104067-TJP1

PRO

Q07157

Pharos - Targets

Q07157

GlyGen

Q07157

PDB

2JWE, 3TSV, 2H2B, 4YYX, 2H2C, 3TSW, 3TSZ, 4Q2Q, 2RCZ, 2KXS, 3SHW, 2KXR, 2H3M, 4OEO, 3CYY, 3LH5, 3SHU, 4OEP

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96J84 KIRREL	1	KIRREL [plasma membrane] (R-HSA-8954311)	0.672	7
UniProt:P17302 GJA1	7	GJA1 [Golgi-associated vesicle membrane] (R-HSA-190544) GJA1 [plasma membrane] (R-HSA-158058) p-Y265-GJA1 [plasma membrane] (R-HSA-191657) GJA1 [lysosomal membrane] (R-HSA-196173) GJA1 [endoplasmic reticulum membrane] (R-HSA-190654) GJA1 [Golgi membrane] (R-HSA-190649) p-S373-GJA1 [plasma membrane] (R-HSA-9857671)	0.646	3
UniProt:O43707 ACTN4	3	ACTN4 [extracellular region] (R-HSA-349729) ACTN4 [platelet alpha granule lumen] (R-HSA-198240) ACTN4 [cytosol] (R-HSA-390558)	0.599	4
UniProt:Q9P2M7 CGN	1	CGN [cell junction] (R-HSA-2134478)	0.564	2
UniProt:Q9EPK5 Wwtr1	4	Wwtr1 [nucleoplasm] (R-MMU-2064930) phospho-Wwtr1 [cytosol] (R-MMU-2028665) Wwtr1 [cytosol] (R-MMU-1629773) Wwtr1 [nucleoplasm] (R-MMU-1629775)	0.544	4
UniProt:P28229	2	Gjc1 [plasma membrane] (R-MMU-383285) Gjc1 [endoplasmic reticulum membrane] (R-MMU-190716)	0.543	3
UniProt:Q8WVZ9 KBTBD7	1	KBTBD7 [cytosol] (R-HSA-5658415)	0.527	3
UniProt:Q8N144 GJD3	1	GJD3 [endoplasmic reticulum membrane] (R-HSA-190629)	0.524	2
UniProt:Q96GC9 VMP1			0.488	2
UniProt:Q9UDY2 TJP2	4	TJP2 [plasma membrane] (R-HSA-351862) TJP2(?-?) [plasma membrane] (R-HSA-351897) TJP2 [cytosol] (R-HSA-2064412) TJP2 [nucleoplasm] (R-HSA-2064410)	0.483	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7
UniProt:Q66GS9 CEP135	1	CEP135 [cytosol] (R-HSA-380266)	0.483	2
UniProt:P08050 Gja1	10	Cx43 [plasma membrane] (R-RNO-191661) Connexin 43 [Golgi membrane] (R-RNO-190650) Cx43 [endoplasmic reticulum membrane] (R-RNO-190688) Gja1 [Golgi membrane] (R-RNO-190649) Gja1 [endoplasmic reticulum membrane] (R-RNO-190654) Gja1 [lysosomal membrane] (R-RNO-196173) phospho-Gja1 [plasma membrane] (R-RNO-191657) Gja1 [plasma membrane] (R-RNO-158058) Cx43 [Golgi-associated vesicle membrane] (R-RNO-190646) Gja1 [Golgi-associated vesicle membrane] (R-RNO-190544)	0.463	2
UniProt:Q9Y5S2 CDC42BPB	1	CDC42BPB [cytosol] (R-HSA-419873)	0.463	3
UniProt:Q3KP66-1 INAVA			0.463	2

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