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PRDX1 [cytosol]
Stable Identifier
R-HSA-3341270
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Peroxiredoxin-1 ecNumber1.11.1.15/ecNumber, PRDX1_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Homo sapiens)
PRDX1,2,5 [cytosol] (Homo sapiens)
PRDX1 dimer [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
CDK5:p25 phosphorylates PRDX1 (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
PRDX1 overoxidizes (Homo sapiens)
HOOS-C52-PRDX1 dimer [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
PRDX1 dimer [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Homo sapiens)
PRDX1,2,5 [cytosol] (Homo sapiens)
PRDX1 dimer [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
SESN1,2,3 bind overoxidized PRDX1 (Homo sapiens)
HOOS-C52-PRDX1 dimer [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
SESN1,2,3:HOOS-C52-PRDX1 dimer [cytosol] (Homo sapiens)
HOOS-C52-PRDX1 dimer [cytosol] (Homo sapiens)
PRDX1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q06830 PRDX1
Gene Names
PRDX1, PAGA, PAGB, TDPX2
Chain
initiator methionine:1, chain:2-199
Reference Genes
BioGPS Gene:5052 PRDX1
COSMIC (genes):PRDX1 PRDX1
CTD Gene:5052 PRDX1
dbSNP Gene:5052 PRDX1
ENSEMBL:ENSG00000117450 PRDX1
ENSEMBL_homo_sapiens_GENE:ENSG00000117450 PRDX1
HGNC:9352 PRDX1
KEGG Gene (Homo sapiens):5052 PRDX1
Monarch:5052 PRDX1
NCBI Gene:5052 PRDX1
OMIM:176763 PRDX1
UCSC:Q06830 PRDX1
Reference Transcript
RefSeq:NM_181697.2 PRDX1
RefSeq:NM_001202431.1 PRDX1
RefSeq:NM_181696.2 PRDX1
RefSeq:NM_002574.3 PRDX1
Other Identifiers
0004070072
00480+1.11.1.15
11742924_a_at
16686472
208680_at
2410244
2410245
2410246
2410247
2410248
2410249
2410250
2410252
2410253
2RII
3198940
3HY2
41213_at
4682
4XCS
5052
7730
7915733
A0A0A0MRQ5
A_23_P11995
A_33_P3377199
AAA50464
AAH07063
AAH21683
AAV38545
ABB84465
BAG70076
BAG70202
CAA48137
CAB004682
CAG28580
CAI13095
CAI13096
CAI13097
CCDS522
EAX06975
EAX06976
EAX06978
EAX06979
EAX06980
EAX06981
EAX06982
ENSG00000117450
ENSP00000262746
ENSP00000361152
ENST00000262746
ENST00000319248
EntrezGene:5052
g440305_3p_s_at
GE62148
GO:0000302
GO:0001501
GO:0001895
GO:0002376
GO:0003674
GO:0003723
GO:0004601
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005829
GO:0006464
GO:0006950
GO:0006979
GO:0007165
GO:0008150
GO:0008283
GO:0008379
GO:0009056
GO:0016209
GO:0016491
GO:0019430
GO:0030101
GO:0031410
GO:0032872
GO:0034101
GO:0034599
GO:0042267
GO:0042470
GO:0042592
GO:0042744
GO:0042802
GO:0043209
GO:0043226
GO:0045296
GO:0045454
GO:0048856
GO:0051186
GO:0051920
GO:0055114
GO:0070062
GO:1901222
HGNC:9352
HPA007730
ILMN_1710159
ILMN_2366388
ILMN_2366391
IPR000866
IPR013766
IPR019479
IPR024706
IPR036249
MIM:176763
MIM:277400
NM_001202431
NM_002574
NM_181696
NM_181697
NP_001189360
NP_002565
NP_859047
NP_859048
PF00578
PF10417
PH_hs_0029347
PRDX1
PRDX1-201
PRDX1-202
TC01002611.hg
uc001coa.4
uc001cob.4
UPI000002FC88
X67951_at
Participant Of
input
CDK5:p25 phosphorylates PRDX1
hasComponent
HOOS-C52-PRDX1 dimer [cytosol]
PRDX1 dimer [cytosol]
Other forms of this molecule
p-T90-PRDX1 [cytosol]
HOOS-C52-PRDX1 [cytosol]
Inferred To
PRDX1 [cytosol] (Arabidopsis thaliana)
PRDX1 [cytosol] (Bos taurus)
PRDX1 [cytosol] (Caenorhabditis elegans)
PRDX1 [cytosol] (Canis familiaris)
PRDX1 [cytosol] (Danio rerio)
PRDX1 [cytosol] (Dictyostelium discoideum)
PRDX1 [cytosol] (Drosophila melanogaster)
PRDX1 [cytosol] (Gallus gallus)
PRDX1 [cytosol] (Oryza sativa)
PRDX1 [cytosol] (Plasmodium falciparum)
PRDX1 [cytosol] (Rattus norvegicus)
PRDX1 [cytosol] (Saccharomyces cerevisiae)
PRDX1 [cytosol] (Schizosaccharomyces pombe)
PRDX1 [cytosol] (Sus scrofa)
PRDX1 [cytosol] (Taeniopygia guttata)
PRDX1 [cytosol] (Xenopus tropicalis)
Homologues of PRDX1 [cytosol] (Arabidopsis thaliana)
Homologues of PRDX1 [cytosol] (Caenorhabditis elegans)
Homologues of PRDX1 [cytosol] (Canis familiaris)
Homologues of PRDX1 [cytosol] (Danio rerio)
Homologues of PRDX1 [cytosol] (Drosophila melanogaster)
Homologues of PRDX1 [cytosol] (Plasmodium falciparum)
Homologues of PRDX1 [cytosol] (Rattus norvegicus)
Homologues of PRDX1 [cytosol] (Saccharomyces cerevisiae)
Homologues of PRDX1 [cytosol] (Sus scrofa)
Prdx1 [cytosol] (Mus musculus)
Cross References
RefSeq
NP_859047.1
,
NP_001189360.1
,
NP_002565.1
,
NP_859048.1
OpenTargets
ENSG00000117450
GeneCards
Q06830
DOCK Blaster
2RII
,
3HY2
,
4XCS
PRO
Q06830
BRENDA (Homo sapiens)
1.11.1.15
HMDB Protein
HMDBP02990
PDB
4XCS
,
3HY2
,
2RII
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13043 STK4
4
STK4(1-487) [cytosol]
(R-HSA-201627)
p-T183-STK4(1-487) [cytosol]
(R-HSA-2028258)
p-T183-STK4(1-326) [cytosol]
(R-HSA-2028682)
STK4(327-487) [cytosol]
(R-HSA-2028668)
0.66
11
UniProt:P60484 PTEN
41
PTEN [nucleoplasm]
(R-HSA-5690148)
K48polyUb-PTEN [cytosol]
(R-HSA-8874327)
PolyUb-PTEN [nucleoplasm]
(R-HSA-6782515)
PTEN H93R [cytosol]
(R-HSA-2318524)
PTEN C124R [cytosol]
(R-HSA-2317439)
PTEN H93Y [cytosol]
(R-HSA-2318520)
PTEN R130G [cytosol]
(R-HSA-2317339)
PTEN H93D [cytosol]
(R-HSA-2318550)
PTEN R130L [cytosol]
(R-HSA-2317430)
PTEN H93A [cytosol]
(R-HSA-2318544)
PTEN G129E [cytosol]
(R-HSA-2318509)
PTEN S170N [cytosol]
(R-HSA-2318408)
PTEN R173P [cytosol]
(R-HSA-2317480)
PTEN R130Q [cytosol]
(R-HSA-2317416)
PTEN H93Q [cytosol]
(R-HSA-2318565)
PTEN G129R [cytosol]
(R-HSA-2318501)
PTEN H123Y [cytosol]
(R-HSA-2318469)
PTEN S170R [cytosol]
(R-HSA-2318437)
PTEN R173C [cytosol]
(R-HSA-2317478)
PTEN R173H [cytosol]
(R-HSA-2317473)
PTEN C124S [cytosol]
(R-HSA-2317379)
PTEN C124Y [cytosol]
(R-HSA-2317464)
PTEN R130P [cytosol]
(R-HSA-2317432)
PTEN C124F [cytosol]
(R-HSA-2317461)
PTEN G129V [cytosol]
(R-HSA-2318503)
PTEN S170I [cytosol]
(R-HSA-2318455)
PTEN S170G [cytosol]
(R-HSA-2318465)
PTEN R233* [cytosol]
(R-HSA-2318573)
PTEN R335* [cytosol]
(R-HSA-2318568)
PTEN R130* [cytosol]
(R-HSA-2318571)
MonoUb-K13,K289-PTEN [cytosol]
(R-HSA-6807247)
MonoUb-K13,K289-PTEN [nucleoplasm]
(R-HSA-6807264)
PTEN [nucleoplasm]
(R-HSA-6807273)
p-Y336-PTEN [cytosol]
(R-HSA-8847980)
K27polyUb-PTEN [cytosol]
(R-HSA-8851009)
RibC-E40,E150,D326-PTEN [cytosol]
(R-HSA-8948798)
PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol]
(R-HSA-8948841)
K48polyUb-K289-PTEN [cytosol]
(R-HSA-8948777)
PTEN [cytosol]
(R-HSA-199420)
p-3S,2T-PTEN [cytosol]
(R-HSA-8850936)
PolyUb-PTEN [cytosol]
(R-HSA-6807280)
0.632
7
UniProt:Q9BYN0 SRXN1
0.618
3
UniProt:P10275 AR
4
SUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
AR [cytosol]
(R-HSA-5618082)
AR [nucleoplasm]
(R-HSA-446174)
0.544
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P54274 TERF1
1
TERF1 [nucleoplasm]
(R-HSA-164618)
0.508
2
UniProt:Q00005 2ABB
0.462
2
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