Reactome | CLTB [clathrin-coated endocytic vesicle membrane]

CLTB [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-5138428

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

Clathrin light chain B, CLCB_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by WNT (Homo sapiens)
  - Beta-catenin independent WNT signaling (Homo sapiens)
    - PCP/CE pathway (Homo sapiens)
      - WNT5A-dependent internalization of FZD4 (Homo sapiens)
        
        WNT5A:FZD4 is endocytosed (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2:AP-2:clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        clathrin:AP-2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        3xCLTC:3(CLTA,B) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLTA,B [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLTB [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P09497 CLTB

Gene Names

CLTB

Chain

chain:1-229

Reference Genes

BioGPS Gene:1212 CLTB

COSMIC (genes):CLTB CLTB

CTD Gene:1212 CLTB

dbSNP Gene:1212 CLTB

ENSEMBL:ENSG00000175416 CLTB

ENSEMBL_homo_sapiens_GENE:ENSG00000175416.16 CLTB

HGNC:2091 CLTB

KEGG Gene (Homo sapiens):1212 CLTB

Monarch:1212 CLTB

NCBI Gene:1212 CLTB

OMIM:118970 CLTB

UCSC:P09497 CLTB

Reference Transcript

Other Identifiers

11734975_a_at

1212

17003065

205172_PM_x_at

205172_x_at

206284_PM_x_at

206284_x_at

211043_PM_s_at

211043_s_at

216934_PM_at

216934_at

2888305

2888306

2888307

2888308

2888309

2888310

2888311

2888312

2888318

2888319

2888320

32522_f_at

32523_at

39307_s_at

39308_r_at

8115918

A_23_P252671

A_23_P60610

A_33_P3328666

GE57859

GO:0005198

GO:0005515

GO:0005794

GO:0005802

GO:0005829

GO:0005886

GO:0005905

GO:0005929

GO:0006886

GO:0016020

GO:0016192

GO:0030118

GO:0030125

GO:0030130

GO:0030132

GO:0030659

GO:0030672

GO:0031410

GO:0032050

GO:0042277

GO:0043226

GO:0043231

GO:0045334

GO:0060170

GO:0072583

GO:0098835

GO:0099631

HMNXSV003006181

HMNXSV003046638

Hs.73919.3.S1_3p_at

ILMN_1674609

ILMN_1709346

PH_hs_0018539

TC05002093.hg

X81637_at

g4502900_3p_s_at

Participates

as a candidate of

CLTA,B [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

CLTB [cytosol]

CLTB [trans-Golgi network membrane]

CLTB [lysosomal membrane]

CLTB [plasma membrane]

Inferred To

clic-1 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

Clc [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

cltb [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)

Cltb [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Cltb [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

CLTB [clathrin-coated endocytic vesicle membrane] (Bos taurus)

CLTB [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

CLTB [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

Cross References

RefSeq

NP_001825.1, NP_009028.1

OpenTargets

ENSG00000175416

GeneCards

P09497

HPA

ENSG00000175416-CLTB

Ensembl

ENST00000310418, ENST00000345807, ENSP00000309415, ENSP00000310812, ENSG00000175416

PRO

P09497

Pharos - Targets

P09497

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14677 CLINT1	1	CLINT1 [cytosol] (R-HSA-429811)	0.527	2
UniProt:P55735 SEC13	4	SEC13 [lysosomal membrane] (R-HSA-9638246) SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012) SEC13 [cytosol] (R-HSA-203981) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994)	0.527	2
UniProt:P42566 EPS15	2	p-Y849 EPS15 [cytosol] (R-HSA-8867028) EPS15 [cytosol] (R-HSA-182920)	0.527	2
UniProt:O00443 PIK3C2A	3	PIK3C2A [Golgi membrane] (R-HSA-432679) PIK3C2A [cytosol] (R-HSA-1604624) PIK3C2A [cytoplasmic vesicle membrane] (R-HSA-432683)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	5

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