Reactome | TNKS1BP1 [cytosol]

TNKS1BP1 [cytosol]

Stable Identifier

R-HSA-430011

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

182 kDa tankyrase-1-binding protein, TB182_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        BTG2 binds CCR4-NOT complex (Homo sapiens)
        
        BTG2:CCR4-NOT [cytosol] (Homo sapiens)
        
        CCR4-NOT Complex [cytosol] (Homo sapiens)
        
        TNKS1BP1 [cytosol] (Homo sapiens)
        
        CCR4-NOT Complex [cytosol] (Homo sapiens)
        
        TNKS1BP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9C0C2 TNKS1BP1

Gene Names

TNKS1BP1, KIAA1741, TAB182

Chain

chain:1-1729

Reference Genes

BioGPS Gene:85456 TNKS1BP1

COSMIC (genes):TNKS1BP1 TNKS1BP1

CTD Gene:85456 TNKS1BP1

dbSNP Gene:85456 TNKS1BP1

ENSEMBL:ENSG00000149115 TNKS1BP1

HGNC:19081 TNKS1BP1

KEGG:hsa:85456 TNKS1BP1

Monarch:85456 TNKS1BP1

NCBI Gene:85456 TNKS1BP1

OMIM:607104 TNKS1BP1

UCSC:Q9C0C2 TNKS1BP1

Reference Transcript

Other Identifiers

11719990_a_at

11719991_x_at

16738409

224792_PM_at

224792_at

3373676

3373677

3373678

3373679

3373682

3373683

3373684

3373685

3373686

3373687

3373690

3373691

3373692

3373693

3373698

3373699

3373700

3373701

3373702

3373703

3373704

3373706

3373707

3373708

3373710

3373711

3373712

3373713

3373714

3373715

3373716

3373717

3373718

3373719

3373720

3373721

3373722

3373723

55689_at

7948176

85456

A_23_P418597

A_33_P3365732

GE88357

GO:0000289

GO:0000792

GO:0005515

GO:0005634

GO:0005694

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005912

GO:0006281

GO:0006302

GO:0007004

GO:0010800

GO:0016071

GO:0019899

GO:0030014

GO:0031954

GO:0032200

GO:0033138

GO:0043226

GO:0044877

GO:0045296

GO:0071479

GO:0071532

HMNXSV003021799

Hs.9645.0.S1_3p_at

ILMN_1690826

PH_hs_0000995

TC11001787.hg

Participates

as a component of

Inferred To

Ghost homologue of TNKS1BP1 [cytosol] (Dictyostelium discoideum)

Ghost homologue of TNKS1BP1 [cytosol] (Sus scrofa)

KIAA1671 [cytosol] (Xenopus tropicalis)

Tnks1bp1 [cytosol] (Mus musculus)

Tnks1bp1 [cytosol] (Rattus norvegicus)

tnks1bp1 [cytosol] (Danio rerio)

TNKS1BP1 [cytosol] (Bos taurus)

TNKS1BP1 [cytosol] (Canis familiaris)

TNKS1BP1 [cytosol] (Gallus gallus)

Cross References

ENSEMBL

ENSG00000149115, ENST00000532437, ENST00000358252, ENSP00000350990, ENSP00000437271

OpenTargets

ENSG00000149115

GeneCards

TNKS1BP1

HPA

ENSG00000149115-TNKS1BP1

PRO

Q9C0C2

Pharos - Targets

Q9C0C2

GlyGen

Q9C0C2

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.643	5
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.623	8
UniProt:P09237 MMP7	6	MMP7(95-267) [extracellular region] (R-HSA-1442479) MMP7(18-267) [extracellular region] (R-HSA-1604734) MMP7(51-267) [extracellular region] (R-HSA-1604766) MMP7(18-50) [extracellular region] (R-HSA-1604759) MMP7(51-94) [extracellular region] (R-HSA-1604760) MMP7(18-94) [extracellular region] (R-HSA-1604729)	0.527	3
UniProt:P52907 CAPZA1	2	CAPZA1(265-276) [extracellular region] (R-HSA-879421) CAPZA1 [cytosol] (R-HSA-879363)	0.527	3
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [nucleoplasm] (R-HSA-4655443) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12

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