Reactome | SIGMAR1 [cytosol]

SIGMAR1 [cytosol]

Stable Identifier

R-HSA-9679757

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Sigma non-opioid intracellular receptor 1, SGMR1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q99720 SIGMAR1

Gene Names

SIGMAR1, OPRS1, SRBP, AAG8

Chain

chain:1-223

Reference Genes

BioGPS Gene:10280 SIGMAR1

COSMIC (genes):SIGMAR1 SIGMAR1

CTD Gene:10280 SIGMAR1

dbSNP Gene:10280 SIGMAR1

ENSEMBL:ENSG00000147955 SIGMAR1

HGNC:8157 SIGMAR1

KEGG Gene (Homo sapiens):10280 SIGMAR1

Monarch:10280 SIGMAR1

NCBI Gene:10280 SIGMAR1

OMIM:601978 SIGMAR1

UCSC:Q99720 SIGMAR1

Reference Transcript

Other Identifiers

0000770750

10280

11716141_a_at

11716142_x_at

11716143_a_at

11740062_a_at

11749330_a_at

11753548_x_at

11755295_x_at

17093507

201692_at

214484_s_at

3204244

3204245

3204246

3204247

3204250

3204252

3204253

3204254

3204255

3204258

3204259

3204260

33879_at

75103_at

8160857

A_23_P146637

GE59453

GO:0003674

GO:0004985

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005637

GO:0005640

GO:0005737

GO:0005783

GO:0005789

GO:0005811

GO:0005886

GO:0005887

GO:0006810

GO:0006869

GO:0006950

GO:0007165

GO:0007399

GO:0008144

GO:0008150

GO:0008219

GO:0014069

GO:0016020

GO:0016021

GO:0022607

GO:0030054

GO:0030426

GO:0031410

GO:0036474

GO:0038003

GO:0038023

GO:0042995

GO:0043226

GO:0043523

GO:0045202

GO:0045211

GO:0048856

GO:0065003

GO:0070207

GO:0098839

Hs.24447.1.S1_3p_a_at

ILMN_1717925

ILMN_2398489

ILMN_3229733

ILMN_3306742

PH_hs_0002153

TC09001042.hg

U79528_s_at

g5032116_3p_at

g5032116_3p_x_at

Participant Of

hasComponent

input

Cross References

RefSeq

NP_671513.1, NP_001269134.1, NP_001269138.1, NP_001269136.1, NP_001269137.1, NP_001269135.1, NP_005857.1

ZINC - World Drugs

SGMR1_HUMAN

OpenTargets

ENSG00000147955

ZINC - FDA approved

SGMR1_HUMAN

ZINC - Substances

SGMR1_HUMAN

ZINC - Biogenic

SGMR1_HUMAN

ZINC target

Q99720

PRO

Q99720

PDB

6DK1, 5HK2, 5HK1, 6DJZ, 6DK0

ZINC - Investigational

SGMR1_HUMAN

ZINC - Metabolites

SGMR1_HUMAN

HPA

ENSG00000147955-SIGMAR1

GeneCards

Q99720

Ensembl

ENSP00000420022, ENST00000353468, ENST00000477726, ENSP00000277010, ENST00000277010, ENSP00000434453, ENSG00000147955

ZINC - Predictions - Purchasable

SGMR1_HUMAN

HMDB Protein

HMDBP07857

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14416 DRD2	1	DRD2 [plasma membrane] (R-HSA-390816)	0.556	5
UniProt:Q92847-1 GHSR			0.543	8
UniProt:P27105 STOM	4	STOM [plasma membrane] (R-HSA-6806258) STOM [azurophil granule membrane] (R-HSA-6800997) STOM [tertiary granule membrane] (R-HSA-6800960) STOM [specific granule membrane] (R-HSA-6799569)	0.508	2
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-713) [extracellular region] (R-HSA-879340)	0.462	3

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