Reactome | AARS2 [mitochondrial matrix]

AARS2 [mitochondrial matrix]

Stable Identifier

R-HSA-379653

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Alanyl-tRNA synthetase 2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q5JTZ9 AARS2

Gene Names

AARS2, AARSL, KIAA1270

Chain

transit peptide:1-23, chain:24-985

Reference Genes

BioGPS Gene:57505 AARS2

COSMIC (genes):AARS2 AARS2

CTD Gene:57505 AARS2

dbSNP Gene:57505 AARS2

ENSEMBL:ENSG00000124608 AARS2

HGNC:21022 AARS2

KEGG:hsa:57505 AARS2

Monarch:57505 AARS2

NCBI Gene:57505 AARS2

OMIM:612035 AARS2

UCSC:Q5JTZ9 AARS2

Reference Transcript

RefSeq:NM_020745.3 AARS2

Other Identifiers

11728815_a_at

11728816_at

17019582

230024_PM_at

230024_at

231845_PM_at

231845_at

2955108

2955109

2955111

2955113

2955115

2955117

2955119

2955120

2955121

2955122

2955123

2955124

2955125

2955127

2955128

2955129

2955130

2955131

2955133

2955134

2955135

2955136

2955137

2955138

2955139

2955140

2955141

2955143

2955144

2955145

2955146

2955147

2955148

2955149

2955150

2955151

53488_at

57505

69408_at

75455_at

8126681

81595_at

A_23_P383688

GE85854

GO:0000049

GO:0000166

GO:0002161

GO:0003676

GO:0003723

GO:0003824

GO:0004812

GO:0004813

GO:0005515

GO:0005524

GO:0005737

GO:0005739

GO:0006399

GO:0006412

GO:0006419

GO:0006520

GO:0008270

GO:0016787

GO:0016874

GO:0043039

GO:0043226

GO:0046872

GO:0070143

GO:0106074

GO:0140098

GO:0140101

HMNXSV003013042

HMNXSV003047639

Hs.143698.0.A1_3p_at

Hs.197668.0.A1_3p_at

ILMN_1674698

PH_hs_0022730

TC06001764.hg

Cross References

ENSEMBL

ENST00000244571, ENSP00000244571, ENSG00000124608

OpenTargets

ENSG00000124608

GeneCards

AARS2

HPA

ENSG00000124608-AARS2

PRO

Q5JTZ9

Pharos - Targets

Q5JTZ9

GlyGen

Q5JTZ9

Orphanet

AARS2

HMDB Protein

HMDBP10671

PDB

6NLQ, 6NOW, 6NLY

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:Q15257-2 PTPA			0.556	3
UniProt:O95968 SG1D1			0.527	2
UniProt:Q08830 FGL1			0.527	2
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.527	3
UniProt:P53597 SUCLG1	1	SUCLG1 [mitochondrial matrix] (R-HSA-156623)	0.527	2
UniProt:P32970 CD70	1	CD70 [plasma membrane] (R-HSA-5667139)	0.527	2
UniProt:Q5BKU9 OXLD1			0.527	2
UniProt:P98179 RBM3			0.527	2
UniProt:P21709 EPHA1	2	p-Y599,Y605-EPHA1 [plasma membrane] (R-HSA-3928336) EPHA1 [plasma membrane] (R-HSA-211415)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	6
UniProt:Q8IWL3 HSCB	5	HSCB [mitochondrial matrix] (R-HSA-1299438) HSCB(1-30) [mitochondrial matrix] (R-HSA-8986120) HSCB(1-235) [mitochondrial inner membrane] (R-HSA-1299443) HSCB [mitochondrial inner membrane] (R-HSA-1299447) HSCB(1-235) [mitochondrial intermembrane space] (R-HSA-1299456)	0.462	2

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