Reactome | HINT1 [nucleoplasm]

HINT1 [nucleoplasm]

Stable Identifier

R-HSA-9825679

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

fullName evidence="27"Adenosine 5'-monophosphoramidase HINT1 ecNumber evidence="6 8 9 10 16 17"3.9.1.-/ecNumber, HINT1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P49773 HINT1

Gene Names

HINT1, HINT, PKCI1, PRKCNH1

Chain

initiator methionine:, chain:2-126

Reference Genes

BioGPS Gene:3094 HINT1

COSMIC (genes):HINT1 HINT1

CTD Gene:3094 HINT1

dbSNP Gene:3094 HINT1

ENSEMBL:ENSG00000169567 HINT1

HGNC:4912 HINT1

Monarch:3094 HINT1

NCBI Gene:3094 HINT1

OMIM:601314 HINT1

UCSC:P49773 HINT1

Reference Transcript

RefSeq:NM_005340.6 HINT1

Other Identifiers

1009_at

11741813_s_at

11741814_x_at

11753759_x_at

11757222_at

11757319_x_at

1555960_PM_at

1555960_at

1555961_PM_a_at

1555961_a_at

16651361

16651363

16651365

16651367

16651369

16651371

16651373

16651375

16651377

16651379

16651385

16651387

16999572

18670212

18670213

18670214

18670215

18670216

18670217

18670218

18670219

18670220

18670221

18670222

200093_PM_s_at

200093_s_at

207721_PM_x_at

207721_x_at

208826_PM_x_at

208826_x_at

2874685

2874687

2874688

2874689

2874690

2874691

2874692

2874693

2874694

2874695

2874696

2874697

2874699

2874701

2874702

2874703

2874706

2874715

2874717

2874719

2874721

2874727

2874729

2874739

3077268

3094

7893001

7893058

7893416

7893686

7893827

7893963

7894474

7894974

7895186

7895418

7896365

7896561

8113873

8113879

A_32_P336445

A_32_P47554

GE80125

GE88685

GO:0000118

GO:0000166

GO:0003824

GO:0005080

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0006355

GO:0006508

GO:0006915

GO:0007165

GO:0008234

GO:0009154

GO:0012501

GO:0016787

GO:0016926

GO:0016929

GO:0043226

GO:0043530

GO:0050850

GO:0055086

GO:0070062

GO:0072332

GO:0140096

GO:1901135

HMNXSV003022648

Hs.256697.2.A1_3p_a_at

ILMN_1807710

PH_hs_0039519

TC05001758.hg

TC05003229.hg

U51004_at

g4885412_3p_s_at

p25345

Participates

as a component of

HINT1 dimer [nucleoplasm] (Homo sapiens)

Other forms of this molecule

Ac-K21,K30 HINT1 [nucleoplasm]

Inferred To

LOC100684571 [nucleoplasm] (Canis familiaris)

HINT1 [nucleoplasm] (Bos taurus)

HINT1 [nucleoplasm] (Canis familiaris)

HINT1 [nucleoplasm] (Dictyostelium discoideum)

HINT1 [nucleoplasm] (Drosophila melanogaster)

HINT1 [nucleoplasm] (Mus musculus)

HINT1 [nucleoplasm] (Plasmodium falciparum)

HINT1 [nucleoplasm] (Rattus norvegicus)

HINT1 [nucleoplasm] (Sus scrofa)

chPKCI [nucleoplasm] (Gallus gallus)

hint1 [nucleoplasm] (Danio rerio)

hint1 [nucleoplasm] (Xenopus tropicalis)

hint-1 [nucleoplasm] (Caenorhabditis elegans)

Homologues of HINT1 [nucleoplasm] (Bos taurus)

Homologues of HINT1 [nucleoplasm] (Canis familiaris)

Cross References

OpenTargets

ENSG00000169567

ENSEMBL

ENST00000304043, ENSP00000304229

HPA

ENSG00000169567-HINT1

ZINC - Substances

HINT1_HUMAN

ZINC target

P49773

PRO

P49773

Pharos - Targets

P49773

GlyGen

P49773

HMDB Protein

HMDBP01653

PDB

5IPC, 6N3Y, 8P8P, 1KPC, 8PA6, 5KM2, 5KM4, 5I2E, 5I2F, 5KM6, 5KMA, 5KLZ, 5KMB, 5KMC, 6G9Z, 5ED6, 6N3X, 6N3V, 1KPF, 5IPE, 6J53, 8PAI, 4ZKV, 6J5Z, 6J5S, 4EQH, 4EQE, 5IPB, 5KM0, 1KPA, 7Q2U, 1KPE, 1KPB, 8PA9, 5KM1, 8PAF, 8WZD, 5KM3, 4ZKL, 6YQM, 6B42, 5O8I, 5WA8, 6N3W, 5WA9, 1AV5, 5EMT, 5IPD, 3TW2, 6J58, 5KLY, 5WAA, 6J64, 6J65, 5ED3, 4EQG

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96RR4 CAMKK2	4	p-CAMKK2 [nucleoplasm] (R-HSA-9618968) CAMKK2 [nucleoplasm] (R-HSA-5336483) p-CAMKK2 [cytosol] (R-HSA-9619358) CAMKK2 [cytosol] (R-HSA-9619231)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	11