Reactome | CTPS1 [cytosol]

CTPS1 [cytosol]

Stable Identifier

R-HSA-73536

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CTP synthase , UTP--ammonia ligase, CTP synthetase

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P17812 CTPS1

Gene Names

CTPS1, CTPS

Chain

chain:1-591

Reference Genes

BioGPS Gene:1503 CTPS1

COSMIC (genes):CTPS1 CTPS1

CTD Gene:1503 CTPS1

dbSNP Gene:1503 CTPS1

ENSEMBL:ENSG00000171793 CTPS1

ENSEMBL:ENSG00000171793.17 CTPS1

HGNC:2519 CTPS1

KEGG Gene (Homo sapiens):1503 CTPS1

Monarch:1503 CTPS1

NCBI Gene:1503 CTPS1

OMIM:123860 CTPS1

UCSC:P17812 CTPS1

Reference Transcript

Other Identifiers

11743907_a_at

11743908_a_at

11747890_a_at

11750141_a_at

1503

16663155

202613_PM_at

202613_at

2332149

2332153

2332154

2332155

2332156

2332159

2332161

2332162

2332163

2332166

2332171

2332173

2332174

2332179

2332180

2332182

2332185

2332187

2332189

2332191

2332192

32441_at

7900510

A_14_P124412

A_33_P3235217

GE62530

GE877025

GO:0000166

GO:0002376

GO:0003824

GO:0003883

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0006139

GO:0006221

GO:0006241

GO:0006520

GO:0006541

GO:0009410

GO:0016020

GO:0016874

GO:0019856

GO:0042098

GO:0042100

GO:0042802

GO:0044210

GO:0055086

GO:0097268

GO:1901135

HMNXSV003045166

TC01000520.hg

X52142_at

g4503132_3p_at

Participates

as a component of

CTPS tetramer [cytosol] (Homo sapiens)

Inferred To

ctps-1 [cytosol] (Caenorhabditis elegans)

CTPS1 [cytosol] (Bos taurus)

CTPS1 [cytosol] (Canis familiaris)

CTPS1 [cytosol] (Gallus gallus)

CTPS1 [cytosol] (Plasmodium falciparum)

CTPS1 [cytosol] (Sus scrofa)

Ctps1 [cytosol] (Mus musculus)

Ctps1 [cytosol] (Rattus norvegicus)

ura7 [cytosol] (Schizosaccharomyces pombe)

URA7 [cytosol] (Saccharomyces cerevisiae)

ctps [cytosol] (Dictyostelium discoideum)

ctps1 [cytosol] (Danio rerio)

ctps1 [cytosol] (Xenopus tropicalis)

CTPsyn [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001896.2, NP_001288166.1

Guide to Pharmacology - Targets

3215

OpenTargets

ENSG00000171793

GeneCards

P17812

HPA

ENSG00000171793-CTPS1

Ensembl

ENST00000372616, ENSP00000497901, ENSG00000171793, ENSP00000497744, ENST00000696070, ENSP00000361699, ENSP00000497602, ENST00000650070, ENST00000649124, ENST00000470271, ENSP00000512372

PRO

P17812

Pharos - Targets

P17812

Orphanet

23253

HMDB Protein

HMDBP00676

PDB

7MIF, 7MIG, 5U03, 2VO1, 7MH0, 7MGZ

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	14
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.564	2

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