Reactome | CTPS1 [cytosol]

CTPS1 [cytosol]

Stable Identifier

R-HSA-73536

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CTP synthase , UTP--ammonia ligase, CTP synthetase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P17812 CTPS1

Gene Names

CTPS1, CTPS

Chain

chain:1-591

Reference Genes

BioGPS Gene:1503 CTPS1

COSMIC - genes:CTPS1 CTPS1

CTD Gene:1503 CTPS1

dbSNP Gene:1503 CTPS1

ENSEMBL:ENSG00000171793 CTPS1

HGNC:2519 CTPS1

KEGG:hsa:1503 CTPS1

Monarch:1503 CTPS1

NCBI Gene:1503 CTPS1

OMIM:123860 CTPS1

UCSC:P17812 CTPS1

Reference Transcript

Other Identifiers

11743907_a_at

11743908_a_at

11747890_a_at

11750141_a_at

1503

16663155

202613_PM_at

202613_at

2332148

2332149

2332150

2332151

2332152

2332153

2332154

2332155

2332156

2332158

2332159

2332161

2332162

2332163

2332164

2332165

2332166

2332170

2332171

2332172

2332173

2332174

2332177

2332178

2332179

2332180

2332182

2332183

2332184

2332185

2332187

2332188

2332189

2332190

2332191

2332192

32441_at

7900510

A_14_P110010

A_14_P124412

A_33_P3235217

GE62530

GE877025

GO:0000166

GO:0002376

GO:0003883

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0006139

GO:0006221

GO:0006241

GO:0009410

GO:0016020

GO:0016874

GO:0019856

GO:0042098

GO:0042100

GO:0042802

GO:0044210

GO:0044281

GO:0055086

GO:0097268

GO:1901135

HMNXSV003045166

PH_hs_0027327

TC01000520.hg

X52142_at

g4503132_3p_at

Participates

as a component of

CTPS tetramer [cytosol] (Homo sapiens)

Inferred To

CTPS1 [cytosol] (Bos taurus)

CTPS1 [cytosol] (Canis familiaris)

CTPS1 [cytosol] (Danio rerio)

CTPS1 [cytosol] (Gallus gallus)

CTPS1 [cytosol] (Mus musculus)

CTPS1 [cytosol] (Plasmodium falciparum)

CTPS1 [cytosol] (Sus scrofa)

Ctps [cytosol] (Drosophila melanogaster)

Ctps1 [cytosol] (Rattus norvegicus)

ura7 [cytosol] (Schizosaccharomyces pombe)

URA7 [cytosol] (Saccharomyces cerevisiae)

ctps [cytosol] (Dictyostelium discoideum)

ctps1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001896.2, XP_054190668.1, XP_054190669.1, XP_024309322.1, XP_024309321.1, NP_001288166.1

Guide to Pharmacology - Targets

3215

OpenTargets

ENSG00000171793

ENSEMBL

ENSG00000171793, ENSP00000497602, ENST00000470271, ENST00000650070, ENSP00000512372, ENSP00000497744, ENST00000696070, ENSP00000361699, ENSP00000497901, ENST00000649124, ENST00000372616

HPA

ENSG00000171793-CTPS1

GeneCards

CTPS1

PRO

P17812

Pharos - Targets

P17812

Orphanet

CTPS1

GlyGen

P17812

PDB

7MIF, 7MH0, 5U03, 2VO1, 7MGZ, 7MIG

HMDB Protein

HMDBP00676

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.706	20
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.564	2

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