Reactome | PSMD11 [nucleoplasm]

PSMD11 [nucleoplasm]

Stable Identifier

R-HSA-174327

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S proteasome non-ATPase regulatory subunit 11, 26S proteasome regulatory subunit S9, 26S proteasome regulatory subunit p44.5

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMD11 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00231 PSMD11

Gene Names

PSMD11

Chain

initiator methionine:1, chain:2-422

Reference Genes

BioGPS Gene:5717 PSMD11

COSMIC (genes):PSMD11 PSMD11

CTD Gene:5717 PSMD11

dbSNP Gene:5717 PSMD11

ENSEMBL:ENSG00000108671 PSMD11

ENSEMBL:ENSG00000108671.11 PSMD11

HGNC:9556 PSMD11

KEGG Gene (Homo sapiens):5717 PSMD11

Monarch:5717 PSMD11

NCBI Gene:5717 PSMD11

OMIM:604449 PSMD11

UCSC:O00231 PSMD11

Reference Transcript

Other Identifiers

11753142_a_at

11753982_a_at

1191_s_at

16833139

208776_PM_at

208776_at

208777_PM_s_at

208777_s_at

3717740

3717741

3717745

3717749

3717750

3717751

3717752

3717753

3717755

3717758

3717761

3717763

3717765

3717767

3717768

3717769

3717770

3717771

3717772

3717774

52399_at

5717

58557_at

58558_g_at

61789_i_at

8006392

AB003102_at

A_23_P207600

A_24_P73962

GE53109

GE85882

GO:0000502

GO:0005198

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005838

GO:0006511

GO:0008541

GO:0016020

GO:0022624

GO:0030154

GO:0030163

GO:0031410

GO:0032991

GO:0034774

GO:0043161

GO:0043226

GO:0043248

GO:0048863

GO:0065003

GO:1904813

HMNXSV003004469

Hs.90744.0.S2_3p_at

ILMN_1800952

PH_hs_0025894

TC17000376.hg

g2150045_3p_a_at

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMD11 [secretory granule lumen]

PSMD11 [extracellular region]

PSMD11 [ficolin-1-rich granule lumen]

PSMD11 [cytosol]

Inferred To

psmd11b [nucleoplasm] (Danio rerio)

Psmd11 [nucleoplasm] (Mus musculus)

Psmd11 [nucleoplasm] (Rattus norvegicus)

psmD11 [nucleoplasm] (Dictyostelium discoideum)

rpn-6.1 [nucleoplasm] (Caenorhabditis elegans)

PSMD11 [nucleoplasm] (Bos taurus)

PSMD11 [nucleoplasm] (Canis familiaris)

PSMD11 [nucleoplasm] (Gallus gallus)

PSMD11 [nucleoplasm] (Sus scrofa)

psmd11 [nucleoplasm] (Xenopus tropicalis)

Rpn6 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_002806.2, NP_001257411.1

OpenTargets

ENSG00000108671

HPA

ENSG00000108671-PSMD11

GeneCards

O00231

Ensembl

ENSP00000497128, ENSP00000261712, ENST00000649012, ENSP00000393185, ENSG00000108671, ENST00000261712, ENST00000457654

PRO

O00231

Pharos - Targets

O00231

PDB

5VHH, 6MSD, 5VHF, 6MSB, 7QYA, 6MSG, 7W3K, 6MSE, 7QXP, 7W3M, 7W3H, 5VFQ, 6MSJ, 7W38, 7QXW, 5VFP, 7W3I, 6MSH, 7W39, 6WJD, 7W3J, 5VFS, 5L4K, 6WJN, 7W3G, 7W37, 5VFR, 6MSK, 7W3B, 7QYB, 5LN3, 5M32, 5VFU, 7QXN, 7W3C, 5VFT, 5GJR, 5T0G, 7QXU, 5T0C, 5GJQ, 7W3A, 5VHI, 7QXX, 5T0J, 5T0I, 5VHS, 5T0H, 7W3F, 8CVT, 7QY7, 5VGZ

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [nucleoplasm] (R-HSA-5689584) UCHL5 [cytosol] (R-HSA-1629778)	0.669	4
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.667	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.597	4
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	3
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.527	3
UniProt:Q96LA8 PRMT6	1	PRMT6 [nucleoplasm] (R-HSA-5226884)	0.508	2