Reactome | Me3K525-EEF2 [cytosol]

Me3K525-EEF2 [cytosol]

Stable Identifier

R-HSA-8932237

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

diphthamide EEF2, eEF2

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Literature References

PubMed ID	Title	Journal	Year
7430147	ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyl-diphthamide and its hydrolysis products Howard, JB, Bodley, JW, Van Ness, BG	J. Biol. Chem.	1980
7000782	ADP-ribosylation of elongation factor 2 by diphtheria toxin. Isolation and properties of the novel ribosyl-amino acid and its hydrolysis products Howard, JB, Bodley, JW, Van Ness, BG	J. Biol. Chem.	1980

External Reference Information

External Reference

UniProt:P13639 EEF2

Gene Names

EEF2, EF2

Chain

initiator methionine:1, chain:2-858

Reference Genes

BioGPS Gene:1938 EEF2

COSMIC (genes):EEF2 EEF2

CTD Gene:1938 EEF2

dbSNP Gene:1938 EEF2

ENSEMBL:ENSG00000167658.16 EEF2

HGNC:3214 EEF2

KEGG Gene (Homo sapiens):1938 EEF2

Monarch:1938 EEF2

NCBI Gene:1938 EEF2

OMIM:130610 EEF2

UCSC:P13639 EEF2

Reference Transcript

RefSeq:NM_001961.3 EEF2

Other Identifiers

11715781_a_at

11715782_a_at

11715783_x_at

11748763_a_at

11748764_x_at

11751022_x_at

11757678_s_at

16867212

18671261

18671262

18671263

18671264

18671265

18671266

18671267

18671268

18671269

18671270

18671271

18671273

18671274

18671275

18671276

1938

200094_PM_s_at

200094_s_at

204102_PM_s_at

204102_s_at

36587_at

3846539

3846540

3846541

3846542

3846543

3846544

3846545

3846548

3846549

3846551

3846553

3846555

3846556

3846557

3846559

3846561

3846562

3846563

3846564

3846565

3846567

3846568

3846569

3846570

8032730

A_24_P87763

GE60349

GO:0000166

GO:0002244

GO:0002376

GO:0003723

GO:0003746

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005844

GO:0005886

GO:0006412

GO:0006414

GO:0016020

GO:0016235

GO:0016787

GO:0019901

GO:0030154

GO:0031410

GO:0034774

GO:0043022

GO:0043226

GO:0045182

GO:0045202

GO:0045296

GO:0045727

GO:0048856

GO:0070062

GO:0110165

GO:1904813

GO:1990904

HMNXSV003054355

ILMN_1738383

PH_hs_0004308

TC19001054.hg

X51466_at

g4503482_3p_a_at

Participates

as an output of

EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Homo sapiens)

Other forms of this molecule

EEF2 [ficolin-1-rich granule lumen]

EEF2 [extracellular region]

EEF2 [secretory granule lumen]

EEF2 [cytosol]

aminocarboxypropyl EEF2 [cytosol]

Me-diphthine EEF2 [cytosol]

nascent EEF2 [cytosol]

diphthine EEF2 [cytosol]

ADP-ribo-EEF2 [cytosol]

Inferred To

Homologues of Me3K525-EEF2 [cytosol] (Danio rerio)

Homologues of Me3K525-EEF2 [cytosol] (Dictyostelium discoideum)

EEF2 [cytosol] (Gallus gallus)

EEF2 [cytosol] (Sus scrofa)

Me3K525-EEF2 [cytosol] (Bos taurus)

Me3K525-EEF2 [cytosol] (Caenorhabditis elegans)

Me3K525-EEF2 [cytosol] (Canis familiaris)

Me3K525-EEF2 [cytosol] (Danio rerio)

Me3K525-EEF2 [cytosol] (Dictyostelium discoideum)

Me3K525-EEF2 [cytosol] (Drosophila melanogaster)

Me3K525-EEF2 [cytosol] (Mus musculus)

Me3K525-EEF2 [cytosol] (Plasmodium falciparum)

Me3K525-EEF2 [cytosol] (Rattus norvegicus)

Me3K525-EEF2 [cytosol] (Saccharomyces cerevisiae)

Me3K525-EEF2 [cytosol] (Schizosaccharomyces pombe)

eef2.1 [cytosol] (Xenopus tropicalis)

cinC [cytosol] (Dictyostelium discoideum)

Modified Residues

Name

dipthamide at 715

Coordinate

715

PsiMod Name

dipthamide

PsiMod Definition

A protein modification that effectively converts an L-histidine residue to diphthamide.

Name

N6,N6,N6-trimethyl-L-lysine at 525

Coordinate

525

PsiMod Name

N6,N6,N6-trimethyl-L-lysine [MOD:00083]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.

Cross References

RefSeq

NP_001952.1

Guide to Pharmacology - Targets

2756

OpenTargets

ENSG00000167658

GeneCards

P13639

HPA

ENSG00000167658-EEF2

Ensembl

ENSG00000167658, ENST00000309311, ENSP00000307940

PRO

P13639

Pharos - Targets

P13639

Orphanet

22496

HMDB Protein

HMDBP02947

PDB

6Z6N, 6Z6M, 4V6X, 6D9J

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9NRI5 DISC1			0.553	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:Q16539 MAPK14	7	MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q99714 HSD17B10	1	HSD17B10 [mitochondrial matrix] (R-HSA-70831)	0.499	3