Reactome | PAICS [cytosol]

PAICS [cytosol]

Stable Identifier

R-HSA-62502

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthase, Multifunctional protein ADE2, Phosphoribosylaminoimidazole- succinocarboxamide synthase , SAICAR synthetase, Phosphoribosylaminoimidazole carboxylase , AIR carboxylase, AIRC

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P22234 PAICS

Gene Names

PAICS, ADE2, AIRC, PAIS

Chain

initiator methionine:1, chain:2-425

Reference Genes

BioGPS Gene:10606 PAICS

COSMIC (genes):PAICS PAICS

CTD Gene:10606 PAICS

dbSNP Gene:10606 PAICS

ENSEMBL:ENSG00000128050 PAICS

HGNC:8587 PAICS

KEGG:hsa:10606 PAICS

Monarch:10606 PAICS

NCBI Gene:10606 PAICS

OMIM:172439 PAICS

UCSC:P22234 PAICS

Reference Transcript

Other Identifiers

10606

11719173_s_at

11754596_x_at

16967031

201013_PM_s_at

201013_s_at

201014_PM_s_at

201014_s_at

214664_PM_at

214664_at

2728185

2728186

2728187

2728188

2728190

2728191

2728192

2728193

2728194

2728195

2728196

2728197

2728198

2728199

2728200

2728202

2728203

2728204

2728207

2728210

2728211

2728212

2728213

2728214

2728215

2728216

2728217

2728218

2728219

2728221

2728223

2728225

2728226

2728227

2728228

2728229

3083452

3083453

39056_at

53375_at

8095221

A_23_P41280

A_24_P200427

GE59787

GE86639

GO:0000166

GO:0003824

GO:0004638

GO:0004639

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0006164

GO:0006177

GO:0006189

GO:0009113

GO:0016020

GO:0016829

GO:0016831

GO:0016874

GO:0042802

GO:0044208

GO:0045296

GO:0055086

GO:0070062

GO:0097294

GO:1901135

HMNXSV003004328

Hs.117950.0.S2_3p_a_at

Hs.117950.1.S1_3p_at

ILMN_1773760

ILMN_2286106

ILMN_2392546

TC04000331.hg

X53793_at

g5453538_3p_a_at

p12730

Participates

as a component of

PAICS octamer [cytosol] (Homo sapiens)

Inferred To

paics [cytosol] (Danio rerio)

paics [cytosol] (Xenopus tropicalis)

Paics [cytosol] (Drosophila melanogaster)

Paics [cytosol] (Mus musculus)

Paics [cytosol] (Rattus norvegicus)

paic-1 [cytosol] (Caenorhabditis elegans)

PAICS [cytosol] (Bos taurus)

PAICS [cytosol] (Canis familiaris)

PAICS [cytosol] (Gallus gallus)

PAICS [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_047305485.1, NP_001072992.1, NP_001072993.1, XP_054204751.1, NP_006443.1

ENSEMBL

ENSG00000128050, ENST00000264221, ENSP00000382595, ENST00000512576, ENSP00000264221, ENSP00000421096, ENST00000399688

OpenTargets

ENSG00000128050

IntEnz

6.3.2.6

GeneCards

PAICS

HPA

ENSG00000128050-PAICS

PRO

P22234

Pharos - Targets

P22234

GlyGen

P22234

HMDB Protein

HMDBP00894

PDB

7ALE, 6YB8, 6YB9, 2H31

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q969R5 L3MBTL2	2	L3MBTL2 [nucleoplasm] (R-HSA-6804477) polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480)	0.718	6
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.556	3
UniProt:Q9UBW7 ZMYM2	7	ZMYM2 [nucleoplasm] (R-HSA-9930820) ZMYM2(1-913)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839016) ZMYM2(1-913)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604544) ZMYM2(1-1059)-p-4Y-FLT3(594-993) fusion [cytosol] (R-HSA-9703309) ZMYM2(1-1057)-p-5Y-FLT3(586-993) fusion [cytosol] (R-HSA-9703319) ZMYM2(1-1059)-FLT3(594-993) fusion [cytosol] (R-HSA-9703310) ZMYM2(1-1057)-FLT3(586-993) fusion [cytosol] (R-HSA-9703311)	0.556	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	7

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