Reactome | COPB2 [endoplasmic reticulum membrane]

COPB2 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-6810957

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Coatomer beta' subunit

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        COPI vesicle uncoating at the ER (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo:NBAS:RINT1:ZW10:STX18:USE1L:BNIP1 [endoplasmic reticulum membrane] (Homo sapiens)
        
        coatomer [endoplasmic reticulum membrane] (Homo sapiens)
        
        trimeric coatomer complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPB2 [endoplasmic reticulum membrane] (Homo sapiens)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo:NBAS:RINT1:ZW10:STX18:USE1L:BNIP1 [endoplasmic reticulum membrane] (Homo sapiens)
        
        coatomer [endoplasmic reticulum membrane] (Homo sapiens)
        
        trimeric coatomer complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPB2 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35606 COPB2

Gene Names

COPB2

Chain

initiator methionine:, chain:2-906

Reference Genes

BioGPS Gene:9276 COPB2

COSMIC (genes):COPB2 COPB2

CTD Gene:9276 COPB2

dbSNP Gene:9276 COPB2

ENSEMBL:ENSG00000184432 COPB2

ENSEMBL_homo_sapiens_GENE:ENSG00000184432.11 COPB2

HGNC:2232 COPB2

KEGG Gene (Homo sapiens):9276 COPB2

Monarch:9276 COPB2

NCBI Gene:9276 COPB2

OMIM:606990 COPB2

UCSC:P35606 COPB2

Reference Transcript

Other Identifiers

11744254_at

11748591_a_at

16959760

201098_PM_at

201098_at

2697796

2697797

2697798

2697799

2697800

2697801

2697802

2697804

2697805

2697807

2697808

2697809

2697810

2697812

2697814

2697815

2697816

2697817

2697819

2697820

2697822

2697823

2697827

2697828

2697829

2697831

2697832

2697834

36677_at

8091048

9276

A_23_P91891

GE59970

GO:0000139

GO:0005198

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0006886

GO:0006888

GO:0006890

GO:0006891

GO:0015031

GO:0016020

GO:0016192

GO:0030117

GO:0030126

GO:0030133

GO:0030663

GO:0031410

GO:0043226

HMNXSV003014232

ILMN_1684385

PH_hs_0004365

RNA147046|p0150_imsncRNA238

TC03001832.hg

TC03003113.hg

X70476_at

g4758031_3p_at

Participates

as a component of

trimeric coatomer complex [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

COPB2 [transport vesicle]

COPB2 [Golgi membrane]

COPB2 [cytosol]

Inferred To

beta'COP [endoplasmic reticulum membrane] (Drosophila melanogaster)

SEC27 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

copb2 [endoplasmic reticulum membrane] (Danio rerio)

copb2 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

copb2 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Copb2 [endoplasmic reticulum membrane] (Mus musculus)

Copb2 [endoplasmic reticulum membrane] (Rattus norvegicus)

COPB2 [endoplasmic reticulum membrane] (Bos taurus)

COPB2 [endoplasmic reticulum membrane] (Canis familiaris)

COPB2 [endoplasmic reticulum membrane] (Gallus gallus)

COPB2 [endoplasmic reticulum membrane] (Sus scrofa)

sec27 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

copb-2 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Cross References

RefSeq

XP_016863001.1, NP_004757.1

OpenTargets

ENSG00000184432

GeneCards

P35606

HPA

ENSG00000184432-COPB2

Ensembl

ENST00000514508, ENSP00000329419, ENST00000507777, ENST00000512242, ENSP00000422469, ENST00000333188, ENSP00000422295, ENSP00000427185, ENSG00000184432

PRO

P35606

Pharos - Targets

P35606

Orphanet

26343

HMDB Protein

HMDBP08330

PDB

8D41, 8D30

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19838 NFKB1	8	NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.689	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	10
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.569	4
UniProt:Q12211 PUS1	1	PUS1 [nucleoplasm] (R-SCE-6790215)	0.556	3
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791)	0.499	3
UniProt:Q9P2Y5 UVRAG	2	UVRAG [cytosol] (R-HSA-5668884) UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9730510)	0.462	6

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