Reactome | 3OHH39-RPL27A [nucleoplasm]

3OHH39-RPL27A [nucleoplasm]

Stable Identifier

R-HSA-9630970

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

3OHH39-60S ribosomal protein L27a, RL27A_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P46776 RPL27A

Gene Names

RPL27A

Chain

chain:1-148

Reference Genes

BioGPS Gene:6157 RPL27A

COSMIC (genes):RPL27A RPL27A

CTD Gene:6157 RPL27A

dbSNP Gene:6157 RPL27A

ENSEMBL:ENSG00000166441 RPL27A

ENSEMBL_homo_sapiens_GENE:ENSG00000166441.13 RPL27A

HGNC:10329 RPL27A

KEGG Gene (Homo sapiens):6157 RPL27A

Monarch:6157 RPL27A

NCBI Gene:6157 RPL27A

OMIM:603637 RPL27A

UCSC:P46776 RPL27A

Reference Transcript

RefSeq:NM_000990.4 RPL27A

Other Identifiers

11736810_at

16721715

203034_3p_s_at

203034_PM_s_at

203034_s_at

223707_PM_at

223707_at

2862831

2980367

2980370

2980371

32436_at

3319589

3319593

3319598

3319603

3319604

3319610

3319611

3319612

3319614

3319615

3319616

3319617

3319618

3319619

3319620

3319626

6157

77583_at

7938286

7938295

81234_at

8180404

83719_at

A_14_P114318

A_23_P203577

A_23_P416305

GE84889

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005829

GO:0005840

GO:0006412

GO:0015934

GO:0016020

GO:0022625

GO:0022626

GO:0043226

GO:0045202

GO:1990904

HMNXSV003013118

HMNXSV003043799

ILMN_1713086

PH_hs_0037283

U14968_at

g13279118_3p_at

g4506624_3p_a_at

g4506624_3p_x_at

Participates

as an output of

RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Homo sapiens)

Other forms of this molecule

RPL27A [nucleoplasm]

RPL27A [cytosol]

Inferred To

3OHH39-RPL27A [nucleoplasm] (Caenorhabditis elegans)

3OHH39-RPL27A [nucleoplasm] (Canis familiaris)

3OHH39-RPL27A [nucleoplasm] (Gallus gallus)

3OHH39-RPL27A [nucleoplasm] (Plasmodium falciparum)

Rpl27al3 [nucleoplasm] (Rattus norvegicus)

LOC106559080 [nucleoplasm] (Canis familiaris)

RpL27A [nucleoplasm] (Drosophila melanogaster)

rpl2802 [nucleoplasm] (Schizosaccharomyces pombe)

RPL27A [nucleoplasm] (Bos taurus)

RPL27A [nucleoplasm] (Canis familiaris)

RPL27A [nucleoplasm] (Sus scrofa)

rpl27a [nucleoplasm] (Dictyostelium discoideum)

Rpl27a [nucleoplasm] (Mus musculus)

Rpl27a [nucleoplasm] (Rattus norvegicus)

rpl2801 [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of 3OHH39-RPL27A [nucleoplasm] (Canis familiaris)

Homologues of 3OHH39-RPL27A [nucleoplasm] (Rattus norvegicus)

Homologues of 3OHH39-RPL27A [nucleoplasm] (Schizosaccharomyces pombe)

RPL28 [nucleoplasm] (Saccharomyces cerevisiae)

Modified Residues

Name

modified L-histidine residue at 39

Coordinate

PsiMod Name

modified L-histidine residue

PsiMod Definition

A protein modification that modifies an L-histidine residue.

Cross References

RefSeq

NP_000981.1

OpenTargets

ENSG00000166441

GeneCards

P46776

HPA

ENSG00000166441-RPL27A

Ensembl

ENSP00000346015, ENSG00000166441, ENST00000314138

PRO

P46776

Pharos - Targets

P46776

PDB

8G61, 8INF, 8FKQ, 8FKX, 8FLF, 4BXF, 6OM0, 8FKP, 8JDJ, 8FL9, 6Y0G, 7XNY, 6QZP, 8FKY, 6OM7, 8OJ5, 8FLA, 8G5Y, 8FLB, 8FKZ, 8IDT, 6OLE, 7F5S, 8FL2, 8OJ0, 6IP5, 8IE3, 8G5Z, 5AJ0, 8JDL, 8INK, 8FL6, 6LSS, 4UG0, 6IP8, 8IR1, 6Y6X, 8FLE, 5LKS, 8G6J, 8IFE, 8FL7, 8GLP, 8IPX, 8A3D, 6XA1, 8IR3, 6OLZ, 4V6X, 6ZME, 8OHD, 8IPY, 8FKS, 6Y2L, 7BHP, 8FKR, 8JDK, 6LU8, 6ZMI, 6ZMO, 8FL3, 8IPD, 6OLF, 8OJ8, 8FLC, 6Y57, 6OLG, 8FKU, 6LQM, 8FKT, 7QVP, 8IDY, 6Z6L, 8IFD, 6LSR, 8FL4, 6IP6, 8JDM, 8QFD, 8Y0X, 8G60, 8INE, 8Y0W, 6Z6M, 7OW7, 8FLD, 5T2C, 8FKW, 6Z6N, 6OLI, 8FKV, 6W6L, 6ZM7

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.643	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.615	3
UniProt:Q86VP6 CAND1	5	CAND1 [cytosol] (R-HSA-5691146) CAND1 [ficolin-1-rich granule lumen] (R-HSA-6801399) CAND1 [extracellular region] (R-HSA-6806498) CAND1 [secretory granule lumen] (R-HSA-6801390) CAND1 [nucleoplasm] (R-HSA-8955089)	0.564	2
UniProt:Q99848 EBNA1BP2	1	EBNA1BP2 [nucleoplasm] (R-HSA-8869325)	0.527	2
UniProt:P13693 TCTP			0.527	2
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	5
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.527	2
UniProt:P13984 GTF2F2	1	GTF2F2 [nucleoplasm] (R-HSA-65567)	0.524	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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