Reactome | MIF [extracellular region]

MIF [extracellular region]

Stable Identifier

R-HSA-212594

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Mif protein

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P14174 MIF

Gene Names

MIF, GLIF, MMIF

Chain

initiator methionine:1, chain:2-115

Reference Genes

BioGPS Gene:4282 MIF

COSMIC (genes):MIF MIF

CTD Gene:4282 MIF

dbSNP Gene:4282 MIF

ENSEMBL:ENSG00000240972 MIF

ENSEMBL:ENSG00000240972.2 MIF

ENSEMBL:ENSG00000276701 MIF

ENSEMBL:ENSG00000276701.2 MIF

HGNC:7097 MIF

KEGG Gene (Homo sapiens):4282 MIF

Monarch:4282 MIF

NCBI Gene:4282 MIF

OMIM:153620 MIF

UCSC:P14174 MIF

Reference Transcript

RefSeq:NM_002415.1 MIF

Other Identifiers

11744470_x_at

11759411_x_at

16928098

217871_PM_s_at

217871_s_at

3939546

3939547

3939548

3939550

3939551

3939553

3939554

4282

8071737

86505_at

895_at

A_23_P91619

GE472279

GE57660

GO:0001516

GO:0001819

GO:0001934

GO:0002020

GO:0002376

GO:0002906

GO:0003824

GO:0004167

GO:0005125

GO:0005126

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006629

GO:0006954

GO:0007166

GO:0008284

GO:0009986

GO:0010629

GO:0010739

GO:0010760

GO:0012501

GO:0016853

GO:0019752

GO:0023052

GO:0030330

GO:0030336

GO:0030890

GO:0031410

GO:0031666

GO:0031982

GO:0032760

GO:0033033

GO:0033138

GO:0034774

GO:0036211

GO:0042056

GO:0042127

GO:0042327

GO:0042802

GO:0043030

GO:0043066

GO:0043226

GO:0043406

GO:0043518

GO:0045087

GO:0048018

GO:0048146

GO:0048870

GO:0050178

GO:0050731

GO:0050918

GO:0051248

GO:0061078

GO:0061081

GO:0065003

GO:0070062

GO:0070207

GO:0070374

GO:0090238

GO:0090398

GO:0098542

GO:0098772

GO:1902166

GO:1904813

GO:2000343

GO:2000773

HMNXSV003018947

ILMN_1807074

L19686_rna1_at

PH_hs_0019453

TC22001456.hg

g4505184_3p_s_at

Participates

as a member of

as a component of

MIF trimer [extracellular region] (Homo sapiens)

Other forms of this molecule

MIF [secretory granule lumen]

MIF [ficolin-1-rich granule lumen]

Inferred To

mif-1 [extracellular region] (Caenorhabditis elegans)

MIF [extracellular region] (Bos taurus)

MIF [extracellular region] (Danio rerio)

MIF [extracellular region] (Gallus gallus)

MIF [extracellular region] (Mus musculus)

MIF [extracellular region] (Plasmodium falciparum)

MIF [extracellular region] (Rattus norvegicus)

MIF [extracellular region] (Sus scrofa)

MIF [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_002406.1

ZINC - World Drugs

MIF_HUMAN

OpenTargets

ENSG00000240972

ZINC - Substances

MIF_HUMAN

ZINC target

P14174

ZINC - Biogenic

MIF_HUMAN

PRO

P14174

PDB

4TRF, 1CA7, 5J7P, 5UMK, 3L5U, 6CBH, 5BSJ, 4OYQ, 5J7Q, 1MIF, 2OOZ, 3CE4, 3DJI, 3L5S, 5BSI, 3L5T, 5HVS, 6BG6, 4XX8, 3L5V, 4GRU, 6BG7, 4PLU, 4XX7, 4P0H, 4K9G, 5UMJ, 3U18, 3B9S, 5XEJ, 4GUM, 4GRO, 3JTU, 4Z15, 1GIF, 5BS9, 1P1G, 1CGQ, 5UZY, 2OOH, 4PKK, 6OYB, 1LJT, 2OOW, 3SMC, 3DJH, 4F2K, 1GCZ, 4GRP, 4PKZ, 5BSC, 4P01, 1GD0, 3SMB, 6OY8, 5HVV, 6FVH, 6B1C, 6OYG, 7KQX, 4ETG, 4Z1T, 5V70, 3WNT, 4GRR, 6B1K, 3WNS, 4WRB, 6OYE, 6FVE, 3IJJ, 5HVT, 3IJG, 6CBF, 4Z1U, 4EVG, 4WR8, 6CBG, 4EUI, 6CB5, 5EIZ, 4GRN, 3HOF, 6B2C, 4TRU, 4OSF, 3WNR, 3L5R, 4GRQ, 5V73, 3JSG, 3L5P, 5B4O, 6PEG, 3JSF

ZINC - Investigational

MIF_HUMAN

ZINC - Metabolites

MIF_HUMAN

IntEnz

5.3.2.1

GeneCards

P14174

HPA

ENSG00000240972-MIF

Ensembl

ENSP00000482779, ENSP00000215754, ENST00000613839, ENST00000215754, ENSG00000276701, ENSG00000240972

Pharos - Targets

P14174

Orphanet

16399

ZINC - Predictions - Purchasable

MIF_HUMAN

HMDB Protein

HMDBP00100

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14174 MIF	3	MIF [secretory granule lumen] (R-HSA-6803282) MIF [ficolin-1-rich granule lumen] (R-HSA-6803289) MIF [extracellular region] (R-HSA-212594)	0.831	7
UniProt:Q96HA8 NTAQ1			0.666	4
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.593	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.591	3
UniProt:O43521-2 BCL2L11			0.581	5
UniProt:P32502	1	GCD7 [cytosol] (R-SCE-72519)	0.556	3
UniProt:Q92743 HTRA1	1	HTRA1 [extracellular region] (R-HSA-8855820)	0.527	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	9

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