Reactome | MIF [extracellular region]

MIF [extracellular region]

Stable Identifier

R-HSA-212594

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Mif protein

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P14174 MIF

Gene Names

MIF, GLIF, MMIF

Chain

initiator methionine:1, chain:2-115

Reference Genes

BioGPS Gene:4282 MIF

COSMIC (genes):MIF MIF

CTD Gene:4282 MIF

dbSNP Gene:4282 MIF

ENSEMBL:ENSG00000240972 MIF

ENSEMBL:ENSG00000276701 MIF

ENSEMBL_homo_sapiens_GENE:ENSG00000240972 MIF

ENSEMBL_homo_sapiens_GENE:ENSG00000276701 MIF

HGNC:7097 MIF

KEGG Gene (Homo sapiens):4282 MIF

Monarch:4282 MIF

NCBI Gene:4282 MIF

OMIM:153620 MIF

UCSC:P14174 MIF

Reference Transcript

RefSeq:NM_002415.1 MIF

Other Identifiers

0002470176

11744470_x_at

11759411_x_at

16928098

1CA7

1CGQ

1GCZ

1GD0

1GIF

1LJT

1MIF

1P1G

217871_s_at

2OOH

2OOW

2OOZ

3868

3939546

3939547

3939548

3939550

3939551

3939553

3939554

3B9S

3CE4

3DJH

3DJI

3HOF

3IJG

3IJJ

3JSF

3JSG

3JTU

3L5P

3L5R

3L5S

3L5T

3L5U

3L5V

3SMB

3SMC

3U18

3WNR

3WNS

3WNT

4282

4ETG

4EUI

4EVG

4F2K

4GRN

4GRO

4GRP

4GRQ

4GRR

4GRU

4GUM

4K9G

4OSF

4OYQ

4P01

4P0H

4PKK

4PKZ

4PLU

4TRF

4TRU

4WR8

4WRB

4XX7

4XX8

4Z15

4Z1T

4Z1U

5284

5B4O

5BS9

5BSC

5BSI

5BSJ

5CG4

5EIZ

5HVS

5HVT

5HVV

5J7P

5J7Q

5UMJ

5UMK

5UZY

5V70

5V73

6B1C

6B1K

6B2C

6BG6

6BG7

6CB5

6CBF

6CBG

6CBH

6FVE

6FVH

8071737

86505_at

895_at

A_23_P91619

AAA21814

AAA35892

AAA36179

AAA36315

AAH00447

AAH07676

AAH08914

AAH13976

AAH22414

AAH53376

AAL78635

AAP35812

ABB96245

ABQ95571

AF469046

AFM09726

AK311929

BAG34870

BC000447

BC007676

BC008914

BC013976

BC022414

BC053376

BT007148

CAA80598

CAB005284

CAG28572

CAG30406

CAG46452

CCDS13819

CCP37995

CH471095

CR407644

CR456520

CR541651

DQ307455

EAW59620

EF611126

ENSG00000240972

ENSG00000276701

ENSP00000215754

ENSP00000482779

ENST00000215754

ENST00000613839

EntrezGene:4282

g4505184_3p_s_at

GE472279

GE57660

GO:0001516

GO:0001934

GO:0002020

GO:0002376

GO:0002906

GO:0003674

GO:0004167

GO:0005102

GO:0005125

GO:0005126

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006464

GO:0006629

GO:0006810

GO:0006950

GO:0006954

GO:0007049

GO:0007165

GO:0007166

GO:0007568

GO:0007569

GO:0008150

GO:0008219

GO:0008283

GO:0009058

GO:0009986

GO:0010469

GO:0010629

GO:0010739

GO:0010760

GO:0016192

GO:0016853

GO:0019752

GO:0019899

GO:0022607

GO:0030330

GO:0030890

GO:0031410

GO:0031666

GO:0031982

GO:0032269

GO:0032760

GO:0033033

GO:0033138

GO:0034774

GO:0035722

GO:0040011

GO:0042056

GO:0042127

GO:0042327

GO:0042592

GO:0042802

GO:0043030

GO:0043066

GO:0043209

GO:0043226

GO:0043312

GO:0043406

GO:0043518

GO:0044281

GO:0045087

GO:0048146

GO:0048870

GO:0050178

GO:0050715

GO:0050731

GO:0050900

GO:0050918

GO:0061078

GO:0061081

GO:0065003

GO:0070062

GO:0070207

GO:0070374

GO:0071157

GO:0090238

GO:0090344

GO:1902166

GO:1904813

GO:2000343

HF564790

HGNC:7097

HPA003868

I4AY87

ILMN_1716169

ILMN_1807074

IPR001398

IPR014347

IPR019829

JQ846015

L10612

L19686

L19686_rna1_at

M25639

M95775

MIF

MIF-201

MIF-204

MIM:153620

MIM:604302

NM_002415

NP_002406

PF01187

PH_hs_0019453

TC22001456.hg

uc002zyr.2

UPI000005273C

Z23063

Participant Of

hasMember

hasComponent

MIF trimer [extracellular region]

Other forms of this molecule

MIF [secretory granule lumen]

MIF [ficolin-1-rich granule lumen]

Inferred To

MIF [extracellular region] (Arabidopsis thaliana)

MIF [extracellular region] (Bos taurus)

MIF [extracellular region] (Caenorhabditis elegans)

MIF [extracellular region] (Danio rerio)

MIF [extracellular region] (Gallus gallus)

MIF [extracellular region] (Mus musculus)

MIF [extracellular region] (Oryza sativa)

MIF [extracellular region] (Plasmodium falciparum)

MIF [extracellular region] (Rattus norvegicus)

MIF [extracellular region] (Sus scrofa)

MIF [extracellular region] (Taeniopygia guttata)

MIF [extracellular region] (Xenopus tropicalis)

Homologues of MIF [extracellular region] (Arabidopsis thaliana)

Homologues of MIF [extracellular region] (Gallus gallus)

Homologues of MIF [extracellular region] (Oryza sativa)

Homologues of MIF [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_002406.1

ZINC - World Drugs

MIF_HUMAN

OpenTargets

ENSG00000240972

ZINC - Substances

MIF_HUMAN

ZINC target

P14174

ZINC - Biogenic

MIF_HUMAN

PRO

P14174

PDB

3L5R, 3JSG, 6B1K, 1CGQ, 4XX8, 4PLU, 4WRB, 6CBH, 4Z1U, 4EVG, 6B1C, 5HVV, 4P0H, 4XX7, 6CBG, 3U18, 3L5P, 6CBF, 3JSF, 4WR8, 5HVT, 5BSJ, 4Z1T, 5BSI, 3HOF, 4F2K, 5HVS, 5UZY, 4PKZ, 4P01, 5BSC, 1MIF, 4OSF, 1GIF, 6CB5, 5BS9, 3SMC, 4EUI, 4PKK, 4TRU, 5V73, 4Z15, 3CE4, 3DJI, 5V70, 3SMB, 1P1G, 1LJT, 5J7Q, 5UMK, 4GRU, 6FVH, 5J7P, 4OYQ, 4GRR, 5UMJ, 6FVE, 4K9G, 2OOZ, 3DJH, 3JTU, 4TRF, 6BG7, 4GRQ, 3WNT, 6BG6, 4ETG, 3L5U, 3B9S, 6B2C, 3WNS, 1CA7, 2OOW, 3L5V, 4GRP, 3WNR, 3IJG, 2OOH, 5XEJ, 4GRO, 5B4O, 3L5S, 3IJJ, 5EIZ, 1GCZ, 3L5T, 4GRN, 4GUM, 1GD0

ZINC - Metabolites

MIF_HUMAN

GeneCards

P14174

DOCK Blaster

3L5S, 5HVT, 4XX7, 4WR8, 4EUI, 3L5V, 4K9G, 3L5U, 1GCZ, 3DJI, 1CA7, 3JSG, 4GUM, 4PKZ, 4WRB, 4Z15, 5HVV, 3JTU, 3B9S, 4GRP, 2OOH, 4TRF, 4P0H, 3WNS, 5J7Q, 5CG4, 4PKK, 3WNT, 3U18, 3IJJ, 3SMC, 4GRU, 5BSJ, 4P01, 5BSI, 4F2K, 2OOZ, 5EIZ, 1CGQ, 4PLU, 5HVS, 1GIF, 3L5R, 3DJH, 4GRN, 3L5P, 3IJG, 4Z1T, 1LJT, 3L5T, 4EVG, 4Z1U, 4OSF, 4OYQ, 3JSF, 5B4O, 1GD0, 3HOF, 4GRQ, 1P1G, 3WNR, 1MIF, 3CE4, 5BSC, 4TRU, 5J7P, 5BS9, 4GRO, 2OOW, 3SMB, 4XX8, 4GRR, 4ETG

BRENDA (Homo sapiens)

5.3.3.12, 5.3.2.1

ZINC - Predictions - Purchasable

MIF_HUMAN

Orphanet

16399

HMDB Protein

HMDBP00100

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14174 MIF	3	MIF [ficolin-1-rich granule lumen] (R-HSA-6803289) MIF [secretory granule lumen] (R-HSA-6803282) MIF [extracellular region] (R-HSA-212594)	0.697	4
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.593	3
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.591	3
UniProt:O43521-2 BCL2L11			0.581	5
UniProt:P32502	1	EIF2B2 [cytosol] (R-SCE-72519)	0.556	3