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ATP2B4 [plasma membrane]
Stable Identifier
R-HSA-418304
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Plasma membrane calcium-transporting ATPase 4, AT2B4_HUMAN, PMCA4
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet calcium homeostasis (Homo sapiens)
Reduction of cytosolic Ca++ levels (Homo sapiens)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Homo sapiens)
ATP2B1-4 [plasma membrane] (Homo sapiens)
ATP2B4 [plasma membrane] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Homo sapiens)
ATP2B1-4 [plasma membrane] (Homo sapiens)
ATP2B4 [plasma membrane] (Homo sapiens)
ATP2B4 binds to NOS1, inhibiting it (Homo sapiens)
ATP2B4 [plasma membrane] (Homo sapiens)
ATP2B4:NOS1 [plasma membrane] (Homo sapiens)
ATP2B4 [plasma membrane] (Homo sapiens)
PRKACA phosphorylates PLN (Homo sapiens)
ATP2B4:NOS1 [plasma membrane] (Homo sapiens)
ATP2B4 [plasma membrane] (Homo sapiens)
PRKACA phosphorylates TNNI3 (Homo sapiens)
ATP2B4:NOS1 [plasma membrane] (Homo sapiens)
ATP2B4 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Ion transport by P-type ATPases (Homo sapiens)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Homo sapiens)
ATP2B1-4 [plasma membrane] (Homo sapiens)
ATP2B4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23634 ATP2B4
Gene Names
ATP2B4, ATP2B2, MXRA1
Chain
chain:1-1241
Reference Genes
BioGPS Gene:493 ATP2B4
COSMIC (genes):ATP2B2 ATP2B4
COSMIC (genes):ATP2B4 ATP2B4
CTD Gene:493 ATP2B4
dbSNP Gene:493 ATP2B4
ENSEMBL:ENSG00000058668 ATP2B4
HGNC:817 ATP2B4
KEGG:hsa:493 ATP2B4
Monarch:493 ATP2B4
NCBI Gene:493 ATP2B4
OMIM:108732 ATP2B4
UCSC:P23634 ATP2B4
Reference Transcript
RefSeq:NM_001684.4 ATP2B4
RefSeq:NM_001001396.2 ATP2B4
Other Identifiers
11718081_a_at
11718082_a_at
11718083_a_at
11746528_a_at
11756038_x_at
16676183
205410_PM_s_at
205410_s_at
212135_PM_s_at
212135_s_at
212136_PM_at
212136_at
2375710
2375711
2375723
2375724
2375726
2375727
2375729
2375730
2375731
2375733
2375735
2375736
2375738
2375739
2375740
2375741
2375742
2375745
2375747
2375748
2375749
2375750
2375751
2375752
2375753
2375754
2375755
2375764
2375765
2375766
2375767
2375768
2375773
2375774
2375775
2375776
2375777
2375778
2375779
2375780
2375781
2375789
40913_at
41089_at
493
7908940
A_14_P115882
A_14_P138032
A_23_P11841
A_24_P405205
A_33_P3327200
GE81055
GE85720
GO:0000166
GO:0003012
GO:0003013
GO:0003407
GO:0003824
GO:0005215
GO:0005388
GO:0005515
GO:0005516
GO:0005524
GO:0005886
GO:0005901
GO:0005929
GO:0006355
GO:0006357
GO:0006816
GO:0006874
GO:0007018
GO:0007283
GO:0010629
GO:0014832
GO:0015085
GO:0016020
GO:0016323
GO:0016525
GO:0016787
GO:0016887
GO:0017080
GO:0019901
GO:0021766
GO:0022414
GO:0030018
GO:0030165
GO:0030315
GO:0030317
GO:0030346
GO:0031514
GO:0032991
GO:0034220
GO:0036126
GO:0036487
GO:0038060
GO:0042383
GO:0043226
GO:0043231
GO:0043537
GO:0045019
GO:0045121
GO:0046872
GO:0048787
GO:0048856
GO:0048870
GO:0050998
GO:0051001
GO:0051480
GO:0051599
GO:0055085
GO:0070588
GO:0070885
GO:0071872
GO:0071878
GO:0097110
GO:0097228
GO:0097553
GO:0098703
GO:0098736
GO:0098772
GO:0098978
GO:0140657
GO:0150104
GO:1900082
GO:1901660
GO:1902083
GO:1902305
GO:1902548
GO:1902806
GO:1903078
GO:1903243
GO:1903249
GO:1903779
GO:1905145
HMNXSV003034763
Hs.305923.2.A1_3p_at
Hs.305923.2.A1_3p_s_at
ILMN_1664772
ILMN_1680579
ILMN_2367753
M83363_at
PH_hs_0032741
TC01001688.hg
g4502288_3p_a_at
Participates
as an input of
ATP2B4 binds to NOS1, inhibiting it (Homo sapiens)
as a component of
ATP2B4:NOS1 [plasma membrane] (Homo sapiens)
as a member of
ATP2B1-4 [plasma membrane] (Homo sapiens)
Inferred To
mca-2 [plasma membrane]
(Caenorhabditis elegans)
Homologues of ATP2B4 [plasma membrane]
(Caenorhabditis elegans)
Homologues of ATP2B4 [plasma membrane]
(Dictyostelium discoideum)
mca-3 [plasma membrane]
(Caenorhabditis elegans)
ATP2B4 [plasma membrane]
(Bos taurus)
ATP2B4 [plasma membrane]
(Caenorhabditis elegans)
ATP2B4 [plasma membrane]
(Canis familiaris)
ATP2B4 [plasma membrane]
(Dictyostelium discoideum)
ATP2B4 [plasma membrane]
(Gallus gallus)
ATP2B4 [plasma membrane]
(Mus musculus)
ATP2B4 [plasma membrane]
(Rattus norvegicus)
ATP2B4 [plasma membrane]
(Saccharomyces cerevisiae)
ATP2B4 [plasma membrane]
(Schizosaccharomyces pombe)
ATP2B4 [plasma membrane]
(Sus scrofa)
PMCA [plasma membrane]
(Drosophila melanogaster)
Cross References
Guide to Pharmacology - Targets
846
ENSEMBL
ENST00000705901
,
ENST00000357681
,
ENST00000341360
,
ENSP00000350310
,
ENSP00000340930
,
ENSP00000516177
OpenTargets
ENSG00000058668
HPA
ENSG00000058668-ATP2B4
PRO
P23634
Pharos - Targets
P23634
GlyGen
P23634
HMDB Protein
HMDBP01347
PDB
2KNE
,
1CFF
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P29476
1
NOS1 [cytosol]
(R-RNO-419293)
0.524
2
UniProt:Q9NYW3 TAS2R7
1
TAS2R7 [plasma membrane]
(R-HSA-3299612)
0.499
2
UniProt:P01258 CALCA
1
CALCA(83-119) [extracellular region]
(R-HSA-419781)
0.499
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
7
UniProt:Q5VYX0 RNLS
1
RNLS [extracellular region]
(R-HSA-8956471)
0.463
3
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