Reactome | PIGS [endoplasmic reticulum membrane]

PIGS [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-162785

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

PIG-S, phosphatidylinositol glycan, class S

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96S52 PIGS

Gene Names

PIGS, UNQ1873/PRO4316

Chain

initiator methionine:, chain:2-555

Reference Genes

BioGPS Gene:94005 PIGS

COSMIC (genes):PIGS PIGS

CTD Gene:94005 PIGS

dbSNP Gene:94005 PIGS

ENSEMBL:ENSG00000087111 PIGS

HGNC:14937 PIGS

Monarch:94005 PIGS

NCBI Gene:94005 PIGS

OMIM:610271 PIGS

UCSC:Q96S52 PIGS

Reference Transcript

RefSeq:NM_033198.3 PIGS

Other Identifiers

11727788_a_at

11749738_a_at

16842637

223148_PM_at

223148_at

3750737

3750738

3750739

3750741

3750742

3750743

3750744

3750745

3750746

3750747

3750748

3750749

3750750

3750751

3750752

3750753

3750754

3750755

3750756

3750757

3750758

3750759

3750760

3750762

3750763

3750764

3750765

3750766

53820_at

8013641

94005

A_23_P66715

A_33_P3315763

A_33_P3354683

GE83622

GE85477

GO:0005515

GO:0005783

GO:0005789

GO:0006506

GO:0006629

GO:0016020

GO:0016255

GO:0042765

GO:0043226

GO:1901135

HMNXSV003024037

ILMN_1691291

PH_hs_0024974

TC17001300.hg

g12654942_3p_at

Participates

as a component of

GPI transamidase [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

PIGS [endoplasmic reticulum membrane] (Bos taurus)

PIGS [endoplasmic reticulum membrane] (Canis familiaris)

PIGS [endoplasmic reticulum membrane] (Sus scrofa)

Pigs [endoplasmic reticulum membrane] (Mus musculus)

Pigs [endoplasmic reticulum membrane] (Rattus norvegicus)

Cross References

ENSEMBL

ENSP00000309430, ENST00000395346, ENST00000308360, ENSP00000378755

OpenTargets

ENSG00000087111

HPA

ENSG00000087111-PIGS

PRO

Q96S52

Pharos - Targets

Q96S52

GlyGen

Q96S52

HMDB Protein

HMDBP07330

PDB

7WLD, 7W72, 8IMX, 8IMY

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	8

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