Reactome | TAX1BP1 [cytosol]

TAX1BP1 [cytosol]

Stable Identifier

R-HSA-937346

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tax1-binding protein 1, TAXB1_HUMAN, TXBP151, T6BP

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q86VP1 TAX1BP1

Gene Names

TAX1BP1, T6BP, PRO0105

Chain

chain:1-789

Reference Genes

BioGPS Gene:8887 TAX1BP1

COSMIC (genes):TAX1BP1 TAX1BP1

CTD Gene:8887 TAX1BP1

dbSNP Gene:8887 TAX1BP1

ENSEMBL:ENSG00000106052 TAX1BP1

ENSEMBL_homo_sapiens_GENE:ENSG00000106052.14 TAX1BP1

HGNC:11575 TAX1BP1

KEGG Gene (Homo sapiens):8887 TAX1BP1

Monarch:8887 TAX1BP1

NCBI Gene:8887 TAX1BP1

OMIM:605326 TAX1BP1

UCSC:Q86VP1 TAX1BP1

Reference Transcript

Other Identifiers

11718271_a_at

11718272_a_at

11746279_a_at

11752194_a_at

11752195_s_at

17044568

200976_PM_s_at

200976_s_at

200977_PM_s_at

200977_s_at

213786_PM_at

213786_at

2994343

2994344

2994346

2994349

2994353

2994355

2994359

2994360

2994361

2994362

2994363

2994364

2994366

2994368

2994374

2994375

2994376

2994377

2994389

2994393

2994394

2994395

2994396

2994397

2994398

2994399

2994400

2994401

2994402

2994403

35279_at

498_at

8131975

8887

A_14_P108046

A_14_P123880

A_14_P125342

A_14_P202326

A_24_P95029

GE55361

GO:0000407

GO:0002376

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005739

GO:0005773

GO:0005776

GO:0005829

GO:0006351

GO:0006355

GO:0006914

GO:0006915

GO:0012501

GO:0019900

GO:0023052

GO:0030674

GO:0031410

GO:0032088

GO:0034144

GO:0039532

GO:0043066

GO:0043226

GO:0045087

GO:0046872

GO:0060090

GO:0070062

GO:0098542

GO:1905161

HMNXSV003053950

Hs.5437.4.S1_3p_at

ILMN_1793118

ILMN_2374770

PH_hs_0000560

TC07000176.hg

U33821_at

g5803188_3p_a_at

Participates

as a component of

TAX1BP1:TNFAIP3 [cytosol] (Homo sapiens)

Inferred To

TAX1BP1 [cytosol] (Bos taurus)

TAX1BP1 [cytosol] (Canis familiaris)

TAX1BP1 [cytosol] (Gallus gallus)

TAX1BP1 [cytosol] (Mus musculus)

TAX1BP1 [cytosol] (Rattus norvegicus)

TAX1BP1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001073333.1, NP_001193831.1, NP_001193830.1, NP_006015.4

OpenTargets

ENSG00000106052

GeneCards

Q86VP1

HPA

ENSG00000106052-TAX1BP1

Ensembl

ENSP00000265393, ENST00000265393, ENSP00000379612, ENSP00000391907, ENST00000433216, ENSG00000106052, ENST00000543117, ENSP00000444811, ENST00000396319

PRO

Q86VP1

Pharos - Targets

Q86VP1

PDB

4NLH, 4BMJ, 5Z7G, 5AAS, 4Z4M, 5YT6, 4Z4K, 2M7Q

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.806	7
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.797	8
UniProt:Q9NWW6 NMRK1	1	NMRK1 [cytosol] (R-HSA-8869628)	0.718	6
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.715	8
UniProt:Q8TC07 TBC1D15	1	TBC1D15 [cytosol] (R-HSA-8854150)	0.556	3
UniProt:Q9P0U4 CXXC1	1	CXXC1 [nucleoplasm] (R-HSA-535610)	0.556	3
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:O15160 POLR1C	2	POLR1C [nucleoplasm] (R-HSA-63498) POLR1C [cytosol] (R-HSA-1964454)	0.556	3
UniProt:Q99958 FOXC2	1	FOXC2 [nucleoplasm] (R-HSA-3927898)	0.556	3
UniProt:P62987 UBA52	20	UBA52(1-76) [endocytic vesicle membrane] (R-HSA-939236) Ub-33-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783187) Ub-63-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783039) Ub-6-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783072) Ub-11-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783059) Ub-48-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783049) Ub-29-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783030) Ub-27-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783043) N6-glycyl-L-lysine-UBA52(1-76) [cytosol] (R-HSA-8869043) adenylatedG76-UBA52(1-76) [nucleoplasm] (R-HSA-8852114) UBA52(1-128) [cytosol] (R-HSA-8853517) adenylatedG76-UBA52(1-76) [cytosol] (R-HSA-8852112) Ub-48-UBA52(1-76) [endoplasmic reticulum membrane] (R-HSA-8943067) Ub-48-UBA52(1-76) [lysosomal membrane] (R-HSA-9762994) Ub-48-UBA52(1-76) [endocytic vesicle membrane] (R-HSA-9763054) UBA52(1-76) [endosome membrane] (R-HSA-939189) UBA52(1-76) [plasma membrane] (R-HSA-3149452) RPL40 [cytosol] (R-HSA-72476) Ub-29-UBA52(1-76) [cytosol] (R-HSA-5689209) Ub-6-UBA52(1-76) [cytosol] (R-HSA-5689082)	0.556	3
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.556	3
UniProt:Q969R5 L3MBTL2	2	L3MBTL2 [nucleoplasm] (R-HSA-6804477) polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480)	0.556	3
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.556	3
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.556	3
UniProt:O15111 CHUK	3	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615)	0.544	2
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	7

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