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KARS [mitochondrial matrix]
Stable Identifier
R-HSA-379617
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Lysyl-tRNA synthetase
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
tRNA Aminoacylation (Homo sapiens)
Mitochondrial tRNA aminoacylation (Homo sapiens)
lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate (Homo sapiens)
KARS dimer [mitochondrial matrix] (Homo sapiens)
KARS [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15046 KARS1
Gene Names
KARS1, KARS, KIAA0070
Chain
initiator methionine:, chain:2-597
Reference Genes
BioGPS Gene:3735 KARS1
COSMIC (genes):KARS KARS1
CTD Gene:3735 KARS1
dbSNP Gene:3735 KARS1
ENSEMBL:ENSG00000065427 KARS
HGNC:6215 KARS1
KEGG:hsa:3735 KARS1
Monarch:3735 KARS1
NCBI Gene:3735 KARS1
OMIM:601421 KARS1
UCSC:Q15046 KARS1
Reference Transcript
RefSeq:NM_005548.2 KARS1
RefSeq:NM_001130089.1 KARS1
Other Identifiers
11733807_a_at
11746688_at
16657337
16657339
16657341
16657343
16657363
16657365
16657369
16657371
16657373
16657375
16657379
16657381
16657383
16657385
16657389
16657391
16657401
16657403
16657419
16828514
18671106
18671107
18671108
18671109
18671110
18671111
18671112
18671113
18671114
18671115
18671116
18671117
18671118
18671119
18671120
18671121
18671122
200079_PM_s_at
200079_s_at
200840_PM_at
200840_at
34336_at
3699758
3699759
3699760
3699762
3699763
3699764
3699765
3699766
3699767
3699768
3699769
3699770
3699771
3699772
3699773
3699774
3699776
3699778
3699779
3699780
3699781
3699782
3699784
3699786
3699787
3699789
3699790
3699791
3699792
3699798
3699818
3699826
3699828
3699830
3699832
3699836
3699840
3699842
3699844
3699846
3699856
3735
7892618
7892886
7892953
7893080
7893113
7893199
7893248
7893362
7893378
7893477
7893502
7893512
7893549
7893933
7894123
7894238
7894245
7894331
7894334
7894414
7894448
7894737
7895038
7895221
7895264
7895419
7895578
7895648
7895770
7895817
7896201
7896362
8002919
A_23_P152487
D31890_at
GE57175
GO:0000049
GO:0000166
GO:0002276
GO:0002376
GO:0002863
GO:0003676
GO:0003723
GO:0003824
GO:0003877
GO:0004812
GO:0004824
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005759
GO:0005829
GO:0005886
GO:0006355
GO:0006399
GO:0006412
GO:0006418
GO:0006430
GO:0006520
GO:0008033
GO:0010165
GO:0015966
GO:0016597
GO:0016740
GO:0016874
GO:0017101
GO:0042802
GO:0042803
GO:0043032
GO:0043226
GO:0045893
GO:0055086
GO:0070371
GO:0140098
HMNXSV003010174
ILMN_1777584
PH_hs_0000387
TC16001284.hg
TC16001967.hg
g11095908_3p_a_at
Participates
as a component of
KARS dimer [mitochondrial matrix] (Homo sapiens)
Other forms of this molecule
p-S207 KARS [nucleoplasm]
p-S207 KARS [cytosol]
KARS [cytosol]
Cross References
RefSeq
NP_001123561.1
,
NP_005539.1
ENSEMBL
ENSP00000325448
,
ENST00000319410
,
ENST00000302445
,
ENSP00000303043
OpenTargets
ENSG00000065427
ZINC - Substances
SYK_HUMAN
ZINC - Biogenic
SYK_HUMAN
ZINC target
Q15046
PRO
Q15046
GlyGen
Q15046
PDB
6ILH
,
7EA9
,
6ILD
,
4DPG
,
4YCU
,
3BJU
,
6CHD
,
4YCW
HPA
ENSG00000065427-KARS1
Pharos - Targets
Q15046
Orphanet
KARS1
ZINC - Predictions - Purchasable
SYK_HUMAN
HMDB Protein
HMDBP00613
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00441 SOD1
5
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
SOD1 [cytosol]
(R-HSA-350697)
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
SOD1 [extracellular region]
(R-HSA-350705)
0.556
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
4
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