Reactome | p-Y-IRS4 [plasma membrane]

p-Y-IRS4 [plasma membrane]

Stable Identifier

R-HSA-2424302

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

pY-IRS4, Insulin receptor substrate 4, IRS4_HUMAN, IRS4

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
    - IGF1R signaling cascade (Homo sapiens)
      - IRS-related events triggered by IGF1R (Homo sapiens)
        
        IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Homo sapiens)
        
        IGF1,2:p-IGF1R:p-IRS1,2,4 [plasma membrane] (Homo sapiens)
        
        p-IRS1,2,4 [plasma membrane] (Homo sapiens)
        
        p-Y-IRS4 [plasma membrane] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
9553137	Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells Lienhard, GE, Fantin, VR, Keller, SR, Sparling, JD, Lavan, BE, Slot, JW	J. Biol. Chem.	1998

External Reference Information

External Reference

UniProt:O14654 IRS4

Gene Names

IRS4

Chain

chain:1-1257

Reference Genes

BioGPS Gene:8471 IRS4

COSMIC (genes):IRS4 IRS4

CTD Gene:8471 IRS4

dbSNP Gene:8471 IRS4

ENSEMBL:ENSG00000133124.12 IRS4

HGNC:6128 IRS4

KEGG Gene (Homo sapiens):8471 IRS4

Monarch:8471 IRS4

NCBI Gene:8471 IRS4

OMIM:300904 IRS4

UCSC:O14654 IRS4

Reference Transcript

RefSeq:NM_003604.2 IRS4

Other Identifiers

11737665_at

1560652_PM_at

1560652_at

17113257

17113260

207403_PM_at

207403_at

33604_at

4017687

4017688

4017689

4017690

4017695

4017696

4017697

4017698

4017699

4017700

4017701

4017702

4017703

4017704

4017705

4017706

4017707

4017708

4056189

4056191

4056192

4056193

4056194

4056195

4056196

4056197

8174444

8471

ADDON002835.hg

A_21_P0006544

A_23_P85039

GE470462

GE79471

GO:0005158

GO:0005515

GO:0005829

GO:0005886

GO:0007165

GO:0008286

GO:0016020

GO:0023052

GO:0043548

HMNXSV003018490

HMNXSV003031383

Hs2.407141.1.S1_3p_at

ILMN_1712774

PH_hs_0009726

TC0X001269.hg

TC0X002182.hg

g4504732_3p_at

p29536

Participates

as a member of

p-IRS1,2,4 [plasma membrane] (Homo sapiens)

Other forms of this molecule

IRS4 [plasma membrane]

Inferred To

phospho-Irs4 [plasma membrane] (Mus musculus)

phospho-irs4a [plasma membrane] (Danio rerio)

phospho-p-Y-IRS4 [plasma membrane] (Canis familiaris)

phospho-p-Y-IRS4 [plasma membrane] (Gallus gallus)

phospho-IRS4 [plasma membrane] (Bos taurus)

phospho-IRS4 [plasma membrane] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_003595.1

OpenTargets

ENSG00000133124

HPA

ENSG00000133124-IRS4

GeneCards

O14654

Ensembl

ENSG00000133124, ENSP00000505547, ENST00000564206

PRO

O14654

Pharos - Targets

O14654

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.642	9
UniProt:P53041 PPP5C	2	PPP5C [nucleoplasm] (R-HSA-5683410) PPP5C [cytosol] (R-HSA-5675402)	0.569	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	2
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.499	2