PTK2 [cytosol]

Stable Identifier
R-HSA-201621
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
FAK1, FADK1, FAK, Focal adhesion kinase 1
Icon
PTK2 [cytosol] icon
PTK2 [cytosol] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:Q05397 PTK2
Gene Names
PTK2, FAK, FAK1
Chain
initiator methionine:1, chain:2-1052
Reference Genes
BioGPS Gene:5747 PTK2
CTD Gene:5747 PTK2
dbSNP Gene:5747 PTK2
ENSEMBL:ENSG00000169398 PTK2
HGNC:9611 PTK2
KEGG Gene (Homo sapiens):5747 PTK2
Monarch:5747 PTK2
NCBI Gene:5747 PTK2
OMIM:600758 PTK2
UCSC:Q05397 PTK2
Reference Transcript
Other Identifiers
0000670044
0002480025
04660+2.7.10.2
11716373_a_at
11716374_s_at
11747793_a_at
1842
1K04
1K05
1MP8
1OW6
1OW7
1OW8
207821_s_at
208820_at
29671
2ETM
2IJM
312_s_at
3156306
3156308
3156309
3156310
3156313
3156315
3156322
3156324
3156328
3156338
3156339
3156342
3156345
3156357
3156358
3156360
3156362
3156366
3156373
3156375
3156377
3156387
3156388
3156392
3156393
3156396
3156397
3156400
3156402
3156404
3156410
3156420
3156425
3156435
3156457
3156464
3156465
36117_at
3B71
3BZ3
3PXK
3S9O
4036
4EBV
4EBW
4GU6
4GU9
4I4E
4I4F
4K8A
4K9Y
4KAB
4KAO
4NY0
4Q9S
52392_s_at
5747
6I8Z
8153223
A_23_P22096
A_23_P324679
A_23_P72050
AAA35819
AAA58469
AAH35404
AC067931
AC100860
AC105009
AC105235
AK304356
B4DWJ1
BAG65198
BC035404
CAB004036
CCDS56557
CCDS6381
E5RFW9
E5RG54
E5RG66
E5RG80
E5RG86
E5RGA6
E5RGP1
E5RH01
E5RH08
E5RH48
E5RHD8
E5RHK7
E5RI03
E5RI29
E5RI72
E5RII9
E5RIK4
E5RIR5
E5RJI4
E5RJP0
E5RJQ2
E7ESA6
E9PEI4
ENSG00000169398
ENSP00000341189
ENSP00000378644
ENSP00000429474
ENSP00000429911
ENST00000340930
ENST00000340930.7
ENST00000395218
ENST00000395218.3
ENST00000521059
ENST00000521059.5
ENST00000522684
ENST00000522684.5
EntrezGene:5747
EntrezGene:PTK2
g5032000_3p_a_at
GE79453
GE85906
GO:0000003
GO:0000165
GO:0000166
GO:0000226
GO:0000902
GO:0001525
GO:0001568
GO:0001570
GO:0001725
GO:0001764
GO:0001890
GO:0001932
GO:0001934
GO:0002376
GO:0003007
GO:0003674
GO:0003779
GO:0004672
GO:0004713
GO:0004715
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005912
GO:0005925
GO:0005938
GO:0006464
GO:0006468
GO:0006629
GO:0006810
GO:0006914
GO:0007010
GO:0007097
GO:0007155
GO:0007165
GO:0007172
GO:0007173
GO:0007179
GO:0007229
GO:0007275
GO:0007411
GO:0008092
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008360
GO:0008432
GO:0009056
GO:0010507
GO:0010594
GO:0010613
GO:0010632
GO:0014068
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016324
GO:0016740
GO:0018108
GO:0019899
GO:0019901
GO:0019903
GO:0021955
GO:0022408
GO:0022607
GO:0030010
GO:0030027
GO:0030054
GO:0030154
GO:0030155
GO:0030198
GO:0030335
GO:0033628
GO:0034330
GO:0038007
GO:0038083
GO:0038096
GO:0040007
GO:0040011
GO:0042127
GO:0042169
GO:0043066
GO:0043087
GO:0043167
GO:0043197
GO:0043226
GO:0043231
GO:0043542
GO:0043552
GO:0045667
GO:0045860
GO:0046621
GO:0046777
GO:0048010
GO:0048013
GO:0048646
GO:0048856
GO:0048870
GO:0050771
GO:0051493
GO:0051893
GO:0051897
GO:0051964
GO:0060396
GO:0065003
GO:0071560
GO:1900024
GO:2000060
GO:2000811
H0YAS0
H0YB16
H0YB33
H0YBZ1
HGNC:9611
HPA001842
HPA029671
Hs.740.1.S2_3p_at
Hs.740.1.S2_3p_x_at
ILMN_1676305
ILMN_1714364
IPR000299
IPR000719
IPR001245
IPR005189
IPR008266
IPR011009
IPR011993
IPR014352
IPR017441
IPR019748
IPR019749
IPR020635
IPR029071
IPR035963
IPR036137
IPR041390
IPR041784
KF458878
KF458882
L05186
L13616
MIM:600758
NM_001199649
NM_001316342
NM_001352694
NM_001352695
NM_001352696
NM_001352698
NM_001352699
NM_001352700
NM_001352701
NM_001352702
NM_001352703
NM_001352704
NM_001352705
NM_001352706
NM_001352707
NM_001352708
NM_001352709
NM_001352710
NM_001352711
NM_001352712
NM_001352713
NM_001352714
NM_001352715
NM_001352716
NM_001352717
NM_001352718
NM_001352719
NM_001352720
NM_001352721
NM_001352722
NM_001352723
NM_001352724
NM_001352725
NM_001352726
NM_001352727
NM_001352728
NM_001352729
NM_001352730
NM_001352731
NM_001352732
NM_001352733
NM_001352734
NM_001352735
NM_001352736
NM_001352737
NM_001352738
NM_001352739
NM_001352740
NM_001352741
NM_001352742
NM_001352743
NM_001352744
NM_001352745
NM_001352746
NM_005607
NM_153831
NP_001186578
NP_001303271
NP_001339623
NP_001339624
NP_001339625
NP_001339627
NP_001339628
NP_001339629
NP_001339630
NP_001339631
NP_001339632
NP_001339633
NP_001339634
NP_001339635
NP_001339636
NP_001339637
NP_001339638
NP_001339639
NP_001339640
NP_001339641
NP_001339642
NP_001339643
NP_001339644
NP_001339645
NP_001339646
NP_001339647
NP_001339648
NP_001339649
NP_001339650
NP_001339651
NP_001339652
NP_001339653
NP_001339654
NP_001339655
NP_001339656
NP_001339657
NP_001339658
NP_001339659
NP_001339660
NP_001339661
NP_001339662
NP_001339663
NP_001339664
NP_001339665
NP_001339666
NP_001339667
NP_001339668
NP_001339669
NP_001339670
NP_001339671
NP_001339672
NP_001339673
NP_001339674
NP_001339675
NP_005598
NP_722560
PF00373
PF03623
PF07714
PF18038
PH_hs_0025321
PR00109
PTK2
PTK2-201
PTK2-202
PTK2-228
PTK2-240
SM00219
SM00295
UPI000007421A
UPI000012A4FB
UPI0001E8F57E
XM_017013664
XM_017013669
XM_017013684
XM_017013688
XM_024447199
XM_024447200
XM_024447201
XM_024447202
XM_024447203
XM_024447204
XM_024447205
XM_024447206
XM_024447207
XM_024447208
XM_024447209
XM_024447210
XM_024447211
XM_024447212
XP_016869153
XP_016869158
XP_016869173
XP_016869177
XP_024302967
XP_024302968
XP_024302969
XP_024302970
XP_024302971
XP_024302972
XP_024302973
XP_024302974
XP_024302975
XP_024302976
XP_024302977
XP_024302978
XP_024302979
XP_024302980
Participant Of
input
hasComponent
hasCandidate
hasMember
Other forms of this molecule
p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
p-Y194,Y397-PTK2 [cytosol]
pY-PTK2 [cytosol]
PTK2(773-1052) [cytosol]
PTK2(1-772) [cytosol]
p-5Y-PTK2 [cytosol]
p-5Y,S732-PTK2 [cytosol]
p-6Y,S732-PTK2 [cytosol]
p-Y397-PTK2 [cytosol]
p-6Y-PTK2 [cytosol]
Inferred To
Ptk2 [cytosol] (Mus musculus)
Ptk2 [cytosol] (Rattus norvegicus)
kin-32 [cytosol] (Caenorhabditis elegans)
ptk2ab [cytosol] (Danio rerio)
ptk2 [cytosol] (Xenopus tropicalis)
Ghost homologue of PTK2 [cytosol] (Sus scrofa)
PTK2 [cytosol] (Bos taurus)
PTK2 [cytosol] (Canis familiaris)
PTK2 [cytosol] (Gallus gallus)
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Investigational
ZINC - Metabolites
HPA
GeneCards
Ensembl
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (26)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P12931 SRC  6 0.922 8
 UniProt:P49023 PXN  4 0.91 17
 UniProt:P04637 TP53  27 0.761 13
 UniProt:P05480 Src  12 0.683 5
 UniProt:P00533 EGFR  59 0.667 4
 UniProt:Q9H3S7 PTPN23  1 0.639 4
 UniProt:P46108 CRK  1 0.635 3
 UniProt:Q92569 PIK3R3  2 0.632 3
 UniProt:P04626 ERBB2  117 0.589 2
 UniProt:P56945 BCAR1  4 0.589 2
 UniProt:P78396 CCNA1  3 0.589 2
 UniProt:P07948 LYN  5 0.573 2
 UniProt:O43294 TGFI1      0.573 2
 UniProt:Q14451 GRB7  1 0.57 3
 UniProt:P29350-3 PTPN6      0.57 3
 UniProt:Q9NP31 SH2D2A  1 0.57 3
 UniProt:Q68CZ2 TNS3  1 0.556 3
 UniProt:O60711 LPXN      0.547 2
 UniProt:P62993 GRB2  1 0.547 2
 UniProt:Q62219 TGFI1      0.524 3
 UniProt:P16144 ITGB4  1 0.524 7
 UniProt:P08631-2 HCK      0.508 2
 UniProt:P29317 EPHA2  2 0.488 3
 UniProt:Q8TEW6 DOK4  1 0.488 2
 UniProt:O60880 SH2D1A  1 0.488 2
 UniProt:Q80ZW7 Q80ZW7      0.463 2
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