Reactome | PTK2 [cytosol]

PTK2

Stable Identifier

R-HSA-201621

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

FAK1, FADK1, FAK, Focal adhesion kinase 1

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
    - Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
      - Phosphorylation of WASP/N-WASP (Homo sapiens)
        
        Src-kinases [cytosol] (Homo sapiens)
        
        PTK2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q05397 PTK2

Gene Names

PTK2, FAK, FAK1

Chain

initiator methionine:1, chain:2-1052

Reference Genes

BioGPS Gene:5747 PTK2

CTD Gene:5747 PTK2

dbSNP Gene:5747 PTK2

ENSEMBL:ENSG00000169398 PTK2

HGNC:9611 PTK2

KEGG Gene (Homo sapiens):hsa:5747 PTK2

KEGG Gene (Homo sapiens):PTK2 PTK2

Monarch:5747 PTK2

NCBI Gene:5747 PTK2

OMIM:600758 PTK2

UCSC:Q05397 PTK2

Reference Transcript

Other Identifiers

0000670044

0002480025

04660+2.7.10.2

11716373_a_at

11716374_s_at

11747793_a_at

1842

1K04

1K05

1MP8

1OW6

1OW7

1OW8

207821_s_at

208820_at

29671

2ETM

2IJM

312_s_at

3156308

3156309

3156310

3156313

3156315

3156322

3156324

3156328

3156338

3156339

3156342

3156345

3156357

3156358

3156360

3156362

3156366

3156373

3156375

3156377

3156387

3156388

3156392

3156393

3156396

3156397

3156400

3156402

3156404

3156410

3156420

3156425

3156435

3156457

3156464

3156465

36117_at

3B71

3BZ3

3PXK

3S9O

4036

4EBV

4EBW

4GU6

4GU9

4I4E

4I4F

4K8A

4K9Y

4KAB

4KAO

4NY0

4Q9S

52392_s_at

5747

8153223

A_23_P22096

A_23_P324679

A_23_P72050

AAA35819

AAA58469

AAH35404

AC067931

AC100860

AC105009

AC105235

AK304356

B4DWJ1

BAG65198

BC035404

CAB004036

CCDS56557

CCDS6381

ENSG00000169398

ENSP00000341189

ENSP00000378644

ENSP00000429474

ENSP00000429911

ENST00000340930

ENST00000395218

ENST00000521059

ENST00000522684

EntrezGene:5747

g5032000_3p_a_at

GE79453

GE85906

GO:0000003

GO:0000165

GO:0000166

GO:0000226

GO:0000902

GO:0001525

GO:0001568

GO:0001570

GO:0001725

GO:0001764

GO:0001890

GO:0001932

GO:0001934

GO:0002376

GO:0003007

GO:0003674

GO:0003779

GO:0004672

GO:0004713

GO:0004715

GO:0004871

GO:0005088

GO:0005102

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0005938

GO:0006461

GO:0006464

GO:0006468

GO:0006629

GO:0006810

GO:0006950

GO:0007010

GO:0007097

GO:0007155

GO:0007165

GO:0007172

GO:0007173

GO:0007179

GO:0007229

GO:0007275

GO:0007411

GO:0008092

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008360

GO:0008432

GO:0009056

GO:0009790

GO:0010594

GO:0010632

GO:0014068

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016324

GO:0016740

GO:0018108

GO:0019899

GO:0019901

GO:0021955

GO:0022408

GO:0022607

GO:0030010

GO:0030027

GO:0030054

GO:0030154

GO:0030198

GO:0030335

GO:0031234

GO:0033628

GO:0034330

GO:0038007

GO:0038083

GO:0038096

GO:0040007

GO:0040011

GO:0040023

GO:0042127

GO:0042169

GO:0043066

GO:0043087

GO:0043167

GO:0043226

GO:0043542

GO:0043547

GO:0043552

GO:0045087

GO:0045667

GO:0045860

GO:0046621

GO:0046777

GO:0048010

GO:0048013

GO:0048646

GO:0048856

GO:0048870

GO:0050771

GO:0051493

GO:0051893

GO:0051897

GO:0051964

GO:0060396

GO:0065003

GO:0071560

GO:0097194

GO:1900024

GO:2000060

GO:2000811

HGNC:9611

HPA001842

HPA029671

Hs.395482

Hs.712239

Hs.735374

Hs.736231

Hs.740.1.S2_3p_at

Hs.740.1.S2_3p_x_at

ILMN_1676305

ILMN_1714364

IPR000299

IPR000719

IPR001245

IPR005189

IPR008266

IPR011009

IPR011993

IPR017441

IPR019748

IPR019749

IPR020635

IPR029071

KF458878

KF458882

L05186

L13616

MIM:600758

NM_001199649

NM_001316342

NM_001352709

NM_001352714

NM_001352717

NM_001352718

NM_005607

NM_153831

NP_001186578

NP_001303271

NP_001339623

NP_001339635

NP_001339636

NP_001339637

NP_001339638

NP_001339640

NP_001339642

NP_001339643

NP_001339644

NP_001339646

NP_001339647

NP_001339648

NP_001339649

NP_001339650

NP_001339651

NP_001339652

NP_001339653

NP_001339654

NP_001339665

NP_005598

NP_722560

PF00373

PF03623

PF07714

PH_hs_0025321

PR00109

PTK2

PTK2-201

PTK2-202

PTK2-228

PTK2-240

SM00219

SM00295

uc003yvs.4

uc003yvu.4

uc011ljr.3

uc064qqp.1

UPI000007421A

UPI000012A4FB

UPI0001E8F57E

XM_005251012

XM_005251013

XM_006716608

XM_006716609

XM_006716610

XM_011517194

XM_017013651

XM_017013652

XM_017013658

XM_017013659

XM_017013660

XM_017013661

XM_017013662

XM_017013663

XM_017013664

XM_017013665

XM_017013667

XM_017013668

XM_017013669

XM_017013670

XM_017013671

XM_017013672

XM_017013673

XM_017013674

XM_017013675

XM_017013676

XM_017013677

XM_017013678

XM_017013679

XM_017013680

XM_017013681

XM_017013682

XM_017013683

XM_017013684

XM_017013685

XM_017013686

XM_017013687

XM_017013688

XM_017013689

XM_017013690

XP_006716672

XP_006716673

XP_011515496

XP_016869141

XP_016869148

XP_016869153

XP_016869157

XP_016869158

XP_016869162

XP_016869169

XP_016869170

XP_016869173

XP_016869177

Participant Of

input

hasCandidate

SRC-1, PTK2 [cytosol]

hasMember

Src-kinases [cytosol]

hasComponent

Other forms of this molecule

p-5Y-PTK2 [cytosol]

p-5Y,S732-PTK2 [cytosol]

p-6Y,S732-PTK2 [cytosol]

PTK2(773-1052) [cytosol]

PTK2(1-772) [cytosol]

p-Y194,Y397,Y576,Y577-PTK2 [cytosol]

p-Y194,Y397-PTK2 [cytosol]

p-Y397-PTK2 [cytosol]

p-6Y-PTK2 [cytosol]

Inferred To

Homologues of PTK2 [cytosol] (Bos taurus)

Homologues of PTK2 [cytosol] (Canis familiaris)

Homologues of PTK2 [cytosol] (Danio rerio)

Homologues of PTK2 [cytosol] (Drosophila melanogaster)

Homologues of PTK2 [cytosol] (Sus scrofa)

Homologues of PTK2 [cytosol] (Xenopus tropicalis)

PTK2 [cytosol] (Bos taurus)

PTK2 [cytosol] (Caenorhabditis elegans)

PTK2 [cytosol] (Canis familiaris)

PTK2 [cytosol] (Danio rerio)

PTK2 [cytosol] (Drosophila melanogaster)

PTK2 [cytosol] (Gallus gallus)

PTK2 [cytosol] (Mus musculus)

PTK2 [cytosol] (Rattus norvegicus)

PTK2 [cytosol] (Sus scrofa)

PTK2 [cytosol] (Taeniopygia guttata)

PTK2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001186578.1, NP_722560.1, XP_016869162.1

Brenda

2.7.10.2

ZINC - World Drugs

FAK1_HUMAN

ZINC - FDA approved

FAK1_HUMAN

ZINC - Substances

FAK1_HUMAN

ZINC target

Q05397

ZINC - Biogenic

FAK1_HUMAN

PRO

Q05397

PDB

4I4F, 4K8A, 4K9Y, 4KAB, 4KAO, 1K04, 4NY0, 4EBV, 4EBW, 2ETM, 1OW8, 1OW7, 1OW6, 1MP8, 4Q9S, 1K05, 3S9O, 3PXK, 3BZ3, 3B71, 2IJM, 4I4E, 4GU9, 4GU6

ZINC - Metabolites

FAK1_HUMAN

GeneCards

Q05397

DOCK Blaster

4GU9, 4K8A, 3PXK, 1OW6, 1OW7, 4K9Y, 1OW8, 3BZ3, 2ETM, 1K04, 1K05, 4I4F, 4I4E, 4KAB, 1MP8, 4Q9S, 4EBW, 4EBV, 4NY0, 4KAO, 3B71, 4GU6, 2IJM, 3S9O

ZINC - Predictions - Purchasable

FAK1_HUMAN

HMDB Protein

HMDBP01281

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P12931 SRC	4	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.922	8
UniProt:P49023 PXN	4	PXN [plasma membrane] (R-HSA-180493) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.878	15
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) PolyUb-TP53 [cytosol] (R-HSA-6793681) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.761	13
UniProt:P05480 Src	10	SRC-2 [cytosol] (R-MMU-191648) phospho-MyrG-p-Y419-SRC [plasma membrane] (R-MMU-1810408) phospho-p-Y419-SRC-1 [plasma membrane] (R-MMU-112331) phospho-MyrG,p-Y530-SRC [plasma membrane] (R-MMU-377598) phospho-p-Y419-SRC [cytosol] (R-MMU-377592) SRC-1 [plasma membrane] (R-MMU-65043) Activated Src [nucleoplasm] (R-MMU-8937700) Src [cytosol] (R-MMU-418782) MyrG-SRC [plasma membrane] (R-MMU-8876922) MyrG-p-Y424-Src [plasma membrane] (R-MMU-9011258)	0.683	5
UniProt:Q9H3S7 PTPN23	1	PTPN23 [nucleoplasm] (R-HSA-9008924)	0.639	4
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.635	3
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.632	3
UniProt:P56945 BCAR1	4	p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y-BCAR1 [cytosol] (R-HSA-372645) BCAR1 [cytosol] (R-HSA-201625) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723)	0.589	2
UniProt:P04626 ERBB2	12	p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) ERBB2 [plasma membrane] (R-HSA-372889) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079)	0.589	2
UniProt:P78396 CCNA1	3	CCNA1 [cytosol] (R-HSA-157446) PolyUb-CCNA1 [nucleoplasm] (R-HSA-6783068) CCNA1 [nucleoplasm] (R-HSA-68891)	0.589	2
UniProt:P07948 LYN	4	LYN [cytosol] (R-HSA-354251) LYN [plasma membrane] (R-HSA-197943) p-Y396-LYN [plasma membrane] (R-HSA-2454229) p-Y397-LYN [cytosol] (R-HSA-8942608)	0.573	2
UniProt:O43294 TGFI1			0.573	2
UniProt:Q14451 GRB7	1	GRB7 [cytosol] (R-HSA-204819)	0.57	3
UniProt:P29350-3 PTPN6			0.57	3
UniProt:Q9NP31 SH2D2A	1	SH2D2A [cytosol] (R-HSA-4420125)	0.57	3
UniProt:Q68CZ2 TNS3	1	TNS3 [cytosol] (R-HSA-8875524)	0.556	3
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.547	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.547	2
UniProt:Q62219 TGFI1			0.524	3
UniProt:P16144 ITGB4	1	ITGB4 [plasma membrane] (R-HSA-215947)	0.524	7
UniProt:P08631-2 HCK			0.508	2
UniProt:P29317 EPHA2	2	p-Y588,Y594-EPHA2 [plasma membrane] (R-HSA-3928380) EPHA2 [plasma membrane] (R-HSA-2682326)	0.488	3
UniProt:Q8TEW6 DOK4	1	DOK4 [cytosol] (R-HSA-8847701)	0.488	2
UniProt:O60880 SH2D1A	1	SH2D1A [cytosol] (R-HSA-5685108)	0.488	2
UniProt:Q80ZW7 Q80ZW7			0.463	2