Reactome | SRP68 [cytosol]

SRP68 [cytosol]

Stable Identifier

R-HSA-445234

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Signal recognition particle 68 kDa protein, SRP68_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UHB9 SRP68

Gene Names

SRP68

Chain

chain:1-627

Reference Genes

BioGPS Gene:6730 SRP68

COSMIC (genes):SRP68 SRP68

CTD Gene:6730 SRP68

dbSNP Gene:6730 SRP68

ENSEMBL:ENSG00000167881 SRP68

ENSEMBL_homo_sapiens_GENE:ENSG00000167881.15 SRP68

HGNC:11302 SRP68

KEGG Gene (Homo sapiens):6730 SRP68

Monarch:6730 SRP68

NCBI Gene:6730 SRP68

OMIM:604858 SRP68

UCSC:Q9UHB9 SRP68

Reference Transcript

Other Identifiers

11718495_a_at

11749745_a_at

16849072

224607_PM_s_at

224607_s_at

3713447

3747386

3749200

3771298

3771299

3771300

3771301

3771302

3771303

3771305

3771308

3771310

3771312

3771313

3771315

3771317

3771318

3771319

3771321

3771322

3771323

3771324

3771326

3771327

3771328

44745_at

6730

78062_at

8018600

87378_at

A_23_P118353

GE81902

GO:0003723

GO:0005047

GO:0005515

GO:0005634

GO:0005730

GO:0005737

GO:0005783

GO:0005786

GO:0005829

GO:0005840

GO:0005925

GO:0006614

GO:0006886

GO:0008312

GO:0009410

GO:0019904

GO:0030942

GO:0043022

GO:0043226

GO:0048500

GO:1990904

HMNXSV003012572

Hs.273307.0.S2_3p_s_at

ILMN_1703524

PH_hs_0014103

PH_hs_0032415

TC17001892.hg

Participates

as a component of

Signal Recognition Particle [cytosol] (Homo sapiens)

Inferred To

SRP68 [cytosol] (Bos taurus)

SRP68 [cytosol] (Canis familiaris)

SRP68 [cytosol] (Gallus gallus)

SRP68 [cytosol] (Plasmodium falciparum)

SRP68 [cytosol] (Saccharomyces cerevisiae)

SRP68 [cytosol] (Sus scrofa)

Homologues of SRP68 [cytosol] (Canis familiaris)

srpa-68 [cytosol] (Caenorhabditis elegans)

Srp68 [cytosol] (Drosophila melanogaster)

Srp68 [cytosol] (Mus musculus)

Srp68 [cytosol] (Rattus norvegicus)

srp68 [cytosol] (Danio rerio)

srp68 [cytosol] (Dictyostelium discoideum)

srp68 [cytosol] (Schizosaccharomyces pombe)

srp68 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001247432.1, NP_055045.2, NP_001247431.1

OpenTargets

ENSG00000167881

GeneCards

Q9UHB9

HPA

ENSG00000167881-SRP68

Ensembl

ENSP00000312066, ENST00000602720, ENSG00000167881, ENST00000539137, ENSP00000446136, ENST00000307877, ENSP00000473613

PRO

Q9UHB9

Pharos - Targets

Q9UHB9

PDB

4P3E, 7QWQ, 5WRV, 7NFX, 4P3F, 8QVW, 5M72, 5M73

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.527	2
UniProt:P62917 RPL8	3	3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976) RPL8 [nucleoplasm] (R-HSA-9630985) RPL8 [cytosol] (R-HSA-72490)	0.527	2
UniProt:P46087 NOP2	1	NOP2 [nucleoplasm] (R-HSA-6790922)	0.527	2
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.527	2
UniProt:P40429 RPL13A	2	p-RPL13A [cytosol] (R-HSA-156829) RPL13A [cytosol] (R-HSA-72412)	0.527	2
UniProt:P62277 RPS13	2	RPS13 [nucleoplasm] (R-HSA-6791198) RPS13 [cytosol] (R-HSA-72331)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.519	7
UniProt:P62753 RPS6	4	RPS6 [nucleoplasm] (R-HSA-6790606) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [cytosol] (R-HSA-72381)	0.483	2

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