Reactome | JUP [plasma membrane]

JUP [plasma membrane]

Stable Identifier

R-HSA-437260

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Junction plakoglobin, PLAK_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Keratinization (Homo sapiens)
  - Formation of the cornified envelope (Homo sapiens)
    - CASP14 cleaves filaggrin (Homo sapiens)
      - Late cornified envelope [plasma membrane] (Homo sapiens)
        
        Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        FLG-Keratin filament network [plasma membrane] (Homo sapiens)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Desmosome [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)
      - Mature cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
        
        Keratin tonofilament:Desmosome network [plasma membrane] (Homo sapiens)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Desmosome [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)
    - CDSN binds the cornified envelope (Homo sapiens)
      - Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        FLG-Keratin filament network [plasma membrane] (Homo sapiens)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Desmosome [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)
      - Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        FLG-Keratin filament network [plasma membrane] (Homo sapiens)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Desmosome [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)
    - Filaggrin binds Keratin tonofilament:Desmosome (Homo sapiens)
      - FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Desmosome [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)
      - Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Desmosome [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)
    - Fillagrin and keratin intermediate filaments polymerise forming a network (Homo sapiens)
      - FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Desmosome [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)
      - FLG-Keratin filament network [plasma membrane] (Homo sapiens)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Desmosome [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)
    - Lamellar bodies bind the early cornified envelope (Homo sapiens)
      - Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        FLG-Keratin filament network [plasma membrane] (Homo sapiens)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Desmosome [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)
      - Early cornified envelope [plasma membrane] (Homo sapiens)
        
        FLG-Keratin filament network [plasma membrane] (Homo sapiens)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Desmosome [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)
    - Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)
      - Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        FLG-Keratin filament network [plasma membrane] (Homo sapiens)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Desmosome [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)
      - Late cornified envelope [plasma membrane] (Homo sapiens)
        
        Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        FLG-Keratin filament network [plasma membrane] (Homo sapiens)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Desmosome [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)
    - PERP binds desmosomes (Homo sapiens)
      - Desmosome [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)
      - Desmosome:PERP [plasma membrane] (Homo sapiens)
        
        Desmosome [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)
    - Plasma membrane resorption (Homo sapiens)
      - Mature cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
        
        Keratin tonofilament:Desmosome network [plasma membrane] (Homo sapiens)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Desmosome [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)
    - Reinforcement of the Cornified Envelope (Homo sapiens)
      - Early cornified envelope [plasma membrane] (Homo sapiens)
        
        FLG-Keratin filament network [plasma membrane] (Homo sapiens)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Desmosome [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)
      - FLG-Keratin filament network [plasma membrane] (Homo sapiens)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
        
        Desmosome [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)
  - Keratin filaments bind cell-cell adhesion complexes (Homo sapiens)
    - Desmosome [plasma membrane] (Homo sapiens)
      - JUP [plasma membrane] (Homo sapiens)
    - Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
      - Desmosome [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - VEGFR2 mediated vascular permeability (Homo sapiens)
        
        PAK1-3 phosphorylates VE-cadherin (Homo sapiens)
        
        VE-cadherin-Catenin complex [plasma membrane] (Homo sapiens)
        
        Beta-catenin/gamma catenin [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)
        
        p-S665-VE-cadherin-Catenin complex [plasma membrane] (Homo sapiens)
        
        Beta-catenin/gamma catenin [plasma membrane] (Homo sapiens)
        
        JUP [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P14923 JUP

Gene Names

JUP, CTNNG, DP3

Chain

chain:1-745

Reference Genes

BioGPS Gene:3728 JUP

COSMIC (genes):JUP JUP

CTD Gene:3728 JUP

dbSNP Gene:3728 JUP

ENSEMBL:ENSG00000173801 JUP

HGNC:6207 JUP

KEGG Gene (Homo sapiens):3728 JUP

Monarch:3728 JUP

NCBI Gene:3728 JUP

OMIM:173325 JUP

UCSC:P14923 JUP

Reference Transcript

Other Identifiers

0004560338

0006450064

11716343_a_at

16844872

201015_s_at

2047_s_at

3728

3757331

3757332

3757333

3757334

3757335

3757336

3757337

3757338

3757339

3757341

3757343

3757344

3757346

3757348

3757349

3757351

3757352

3757353

3757354

3757355

3757356

3757357

3757358

3757359

3757361

3757366

3757370

3757371

8015412

A_23_P501822

GE60426

GO:0001533

GO:0001954

GO:0002159

GO:0002376

GO:0003013

GO:0003674

GO:0003713

GO:0005198

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005882

GO:0005886

GO:0005911

GO:0005912

GO:0005915

GO:0005916

GO:0005925

GO:0006810

GO:0006913

GO:0007155

GO:0007165

GO:0007267

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0009058

GO:0009898

GO:0014704

GO:0015031

GO:0015629

GO:0016020

GO:0016192

GO:0016327

GO:0016328

GO:0016342

GO:0016477

GO:0019899

GO:0019901

GO:0019903

GO:0022607

GO:0030018

GO:0030054

GO:0030057

GO:0030154

GO:0030674

GO:0031410

GO:0031424

GO:0032991

GO:0032993

GO:0034330

GO:0034332

GO:0034641

GO:0035257

GO:0035580

GO:0040011

GO:0042127

GO:0042307

GO:0042803

GO:0043226

GO:0043312

GO:0043537

GO:0043588

GO:0044877

GO:0045294

GO:0045296

GO:0045766

GO:0045944

GO:0048646

GO:0048856

GO:0048870

GO:0050839

GO:0050982

GO:0051091

GO:0070062

GO:0070268

GO:0071603

GO:0071665

GO:0071681

GO:0072659

GO:0086073

GO:0086083

GO:0086091

GO:0090263

GO:0098609

GO:0098911

GO:0106006

GO:1904813

HMNXSV003035004

ILMN_1733811

ILMN_1741970

ILMN_2366864

PH_hs_0000315

TC17002907.hg

Z68228_s_at

g12056467_3p_a_at

Participates

as a component of

Desmosome [plasma membrane] (Homo sapiens)

as a member of

Beta-catenin/gamma catenin [plasma membrane] (Homo sapiens)

Other forms of this molecule

JUP [cytosol]

JUP [cornified envelope]

JUP [specific granule lumen]

JUP [extracellular region]

JUP [ficolin-1-rich granule lumen]

Inferred To

jupa [plasma membrane] (Danio rerio)

arm [plasma membrane] (Drosophila melanogaster)

wrm-1 [plasma membrane] (Caenorhabditis elegans)

bar-1 [plasma membrane] (Caenorhabditis elegans)

Homologues of JUP [plasma membrane] (Caenorhabditis elegans)

Jup [plasma membrane] (Mus musculus)

Jup [plasma membrane] (Rattus norvegicus)

JUP [plasma membrane] (Canis familiaris)

JUP [plasma membrane] (Gallus gallus)

JUP [plasma membrane] (Sus scrofa)

Ghost homologue of JUP [plasma membrane] (Xenopus tropicalis)

hmp-2 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_002221.1, XP_011523060.1, XP_006721941.1, XP_011523057.1, XP_011523059.1, XP_011523055.1, XP_011523058.1, XP_016880079.1, XP_006721938.1, NP_068831.1, XP_006721936.1, XP_006721937.1

OpenTargets

ENSG00000173801

GeneCards

P14923

HPA

ENSG00000173801-JUP

Ensembl

ENSP00000377508, ENST00000310706, ENST00000393931, ENST00000393930, ENSP00000377507, ENSP00000311113, ENSG00000173801

PRO

P14923

Pharos - Targets

P14923

GlyGen

P14923

Orphanet

16283

PDB

3IFQ

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.781	7
UniProt:Q9NSA3 CTNNBIP1	1	CTNNBIP1 [nucleoplasm] (R-HSA-3772388)	0.749	5
UniProt:O15169 AXIN1	11	AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 Y346* [cytosol] (R-HSA-4839753) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 [cytosol] (R-HSA-195249) p-T519,S524,S531-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.666	4
UniProt:P25054 APC	20	APC R405* [cytosol] (R-HSA-9666936) APC G1288* [cytosol] (R-HSA-9666930) APC S1281* [cytosol] (R-HSA-9666937) APC C1410* [cytosol] (R-HSA-9666925) APC Q1469* [cytosol] (R-HSA-9666935) APC S1400* [cytosol] (R-HSA-9666942) APC K1310* [cytosol] (R-HSA-9666926) APC R564* [cytosol] (R-HSA-9666928) APC R499* [cytosol] (R-HSA-9666927) APC S1346* [cytosol] (R-HSA-9666943) APC E1536* [cytosol] (R-HSA-9666929) APC R1450* [cytosol] (R-HSA-5251499) APC S1327* [cytosol] (R-HSA-9666933) APC G1357* [cytosol] (R-HSA-9666940) APC R213* [cytosol] (R-HSA-9666924) APC E1209* [cytosol] (R-HSA-9666934) APC L1488* [cytosol] (R-HSA-9666941) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932)	0.64	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) CTNNB1 S45F [cytosol] (R-HSA-4791268) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45P [cytosol] (R-HSA-4791272) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619)	0.615	3
UniProt:P16284 PECAM1	4	PECAM1 [secretory granule membrane] (R-HSA-6804778) PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [platelet alpha granule membrane] (R-HSA-61489) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007)	0.61	7
UniProt:P15924 DSP	4	DSP [ficolin-1-rich granule membrane] (R-HSA-6801396) DSP [cornified envelope] (R-HSA-8847736) DSP(?-?) [plasma membrane] (R-HSA-351843) DSP [plasma membrane] (R-HSA-201580)	0.573	3
UniProt:P00533 EGFR	20	p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211)	0.553	2
UniProt:P35221 CTNNA1	2	CTNNA1 [plasma membrane] (R-HSA-191735) CTNNA1 [cytosol] (R-HSA-191697)	0.519	2
UniProt:P03372 ESR1	8	Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [cytosol] (R-HSA-9020968) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) PalmS-ESR1 [cytosol] (R-HSA-9020974) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302)	0.462	2