Reactome | MCAM [plasma membrane]

MCAM [plasma membrane]

Stable Identifier

R-HSA-197922

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Cell surface glycoprotein MUC18 precursor, MU18_HUMAN, CD146

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P43121 MCAM

Gene Names

MCAM, MUC18

Chain

signal peptide:1-23, chain:24-646

Reference Genes

BioGPS Gene:4162 MCAM

COSMIC (genes):MCAM MCAM

CTD Gene:4162 MCAM

dbSNP Gene:4162 MCAM

ENSEMBL:ENSG00000076706 MCAM

ENSEMBL_homo_sapiens_GENE:ENSG00000076706.17 MCAM

HGNC:6934 MCAM

KEGG Gene (Homo sapiens):4162 MCAM

Monarch:4162 MCAM

NCBI Gene:4162 MCAM

OMIM:155735 MCAM

UCSC:P43121 MCAM

Reference Transcript

RefSeq:NM_006500.2 MCAM

Other Identifiers

11724459_x_at

11724460_a_at

16745281

209086_PM_x_at

209086_x_at

209087_PM_x_at

209087_x_at

210869_PM_s_at

210869_s_at

211340_PM_s_at

211340_s_at

3394268

3394269

3394270

3394271

3394272

3394273

3394274

3394275

3394276

3394279

3394280

3394282

3394285

3394287

3394288

3394289

3394290

3394291

3394292

3394294

3394297

3394298

3394299

3394300

3394303

4162

7952205

87991_at

A_23_P162171

A_24_P326660

GE61063

GO:0001525

GO:0003014

GO:0003094

GO:0005576

GO:0005615

GO:0005886

GO:0005925

GO:0007155

GO:0009653

GO:0009897

GO:0016020

GO:0030335

GO:0042060

GO:0048856

GO:0048870

GO:0061042

HMNXSV003016057

Hs.211579.2.S1_3p_a_at

ILMN_1685275

M28882_s_at

M29277_s_at

PH_hs_0026600

TC11002366.hg

g4336423_3p_a_at

Participates

as a candidate of

Inferred To

Mcam [plasma membrane] (Mus musculus)

Mcam [plasma membrane] (Rattus norvegicus)

MCAM [plasma membrane] (Bos taurus)

MCAM [plasma membrane] (Canis familiaris)

MCAM [plasma membrane] (Dictyostelium discoideum)

MCAM [plasma membrane] (Gallus gallus)

MCAM [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_006491.2

Guide to Pharmacology - Targets

2988

OpenTargets

ENSG00000076706

HPA

ENSG00000076706-MCAM

GeneCards

P43121

Ensembl

ENST00000264036, ENSP00000264036, ENSG00000076706

PRO

P43121

Pharos - Targets

P43121

PDB

6LYN

HMDB Protein

HMDBP07819

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	7

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