Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-S395, S405-LMNB1 [nucleoplasm]
Stable Identifier
R-HSA-5228738
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prophase (Homo sapiens)
Nuclear Envelope Breakdown (Homo sapiens)
Depolymerization of the Nuclear Lamina (Homo sapiens)
CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Homo sapiens)
p-S395-Lamin dimers [nucleoplasm] (Homo sapiens)
p-S395, S405-Lamin B1 dimer [nucleoplasm] (Homo sapiens)
p-S395, S405-LMNB1 [nucleoplasm] (Homo sapiens)
Depolymerization of lamin filaments after PKC-mediated phosphorylation (Homo sapiens)
p-S395-Lamin dimers [nucleoplasm] (Homo sapiens)
p-S395, S405-Lamin B1 dimer [nucleoplasm] (Homo sapiens)
p-S395, S405-LMNB1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20700 LMNB1
Gene Names
LMNB1, LMN2, LMNB
Chain
initiator methionine:, chain:2-583, propeptide:584-586
Reference Genes
BioGPS Gene:4001 LMNB1
COSMIC (genes):LMNB1 LMNB1
CTD Gene:4001 LMNB1
dbSNP Gene:4001 LMNB1
ENSEMBL:ENSG00000113368 LMNB1
ENSEMBL_homo_sapiens_GENE:ENSG00000113368.12 LMNB1
HGNC:6637 LMNB1
KEGG Gene (Homo sapiens):4001 LMNB1
Monarch:4001 LMNB1
NCBI Gene:4001 LMNB1
OMIM:150340 LMNB1
UCSC:P20700 LMNB1
Reference Transcript
RefSeq:NM_005573.3 LMNB1
Other Identifiers
11732533_a_at
11744888_a_at
11744889_a_at
11750441_a_at
11750442_s_at
16988703
203276_PM_at
203276_at
2827186
2827187
2827188
2827189
2827192
2827193
2827195
2827196
2827199
2827202
2827203
2827204
2827205
2827207
2827208
2827209
2827210
37985_at
4001
8107706
A_14_P108109
A_23_P258493
GO:0003677
GO:0003690
GO:0005198
GO:0005200
GO:0005515
GO:0005634
GO:0005635
GO:0005637
GO:0005638
GO:0005652
GO:0005654
GO:0005856
GO:0005882
GO:0006325
GO:0006998
GO:0007010
GO:0007097
GO:0016020
GO:0016363
GO:0031507
GO:0031965
GO:0034399
GO:0043226
GO:0043274
GO:0051664
GO:0061024
GO:0090435
GO:1990837
HMNXSV003035906
M34458_rna1_s_at
PH_hs_0004988
PH_hs_0040083
TC05000604.hg
g5031876_3p_at
g5031876_3p_x_at
Participates
as a component of
p-S395, S405-Lamin B1 dimer [nucleoplasm] (Homo sapiens)
Other forms of this molecule
LMNB1 [nucleoplasm]
LMNB1(1-231) [nuclear envelope]
LMNB1(232-586) [nuclear envelope]
LMNB1 [cytosol]
p-S23, S395, S405-LMNB1 [nucleoplasm]
LMNB1(2-586) [nuclear envelope]
p-S23,S393-LMNB1 [nucleoplasm]
Inferred To
phospho-ifa-1 [nucleoplasm]
(Caenorhabditis elegans)
phospho-LMNB1 [nucleoplasm]
(Bos taurus)
phospho-LMNB1 [nucleoplasm]
(Canis familiaris)
phospho-LMNB1 [nucleoplasm]
(Sus scrofa)
phospho-ifb-2 [nucleoplasm]
(Caenorhabditis elegans)
phospho-lmnb1 [nucleoplasm]
(Danio rerio)
phospho-lmnb1 [nucleoplasm]
(Xenopus tropicalis)
phospho-Lam [nucleoplasm]
(Drosophila melanogaster)
phospho-ifp-1 [nucleoplasm]
(Caenorhabditis elegans)
phospho-LamC [nucleoplasm]
(Drosophila melanogaster)
Homologues of p-S395, S405-LMNB1 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of p-S395, S405-LMNB1 [nucleoplasm]
(Drosophila melanogaster)
phospho-p-S395, S405-LMNB1 [nucleoplasm]
(Gallus gallus)
phospho-ifa-3 [nucleoplasm]
(Caenorhabditis elegans)
phospho-ifd-1 [nucleoplasm]
(Caenorhabditis elegans)
phospho-mua-6 [nucleoplasm]
(Caenorhabditis elegans)
phospho-ifd-2 [nucleoplasm]
(Caenorhabditis elegans)
phospho-Lmnb1 [nucleoplasm]
(Mus musculus)
phospho-Lmnb1 [nucleoplasm]
(Rattus norvegicus)
phospho-ifa-4 [nucleoplasm]
(Caenorhabditis elegans)
phospho-lmn-1 [nucleoplasm]
(Caenorhabditis elegans)
phospho-yuri [nucleoplasm]
(Drosophila melanogaster)
phospho-ifc-2 [nucleoplasm]
(Caenorhabditis elegans)
phospho-ifc-1 [nucleoplasm]
(Caenorhabditis elegans)
phospho-ifb-1 [nucleoplasm]
(Caenorhabditis elegans)
Modified Residues
Name
O-phospho-L-serine at 395
Coordinate
395
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 405
Coordinate
405
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_005564.1
OpenTargets
ENSG00000113368
HPA
ENSG00000113368-LMNB1
GeneCards
P20700
Ensembl
ENSP00000261366
,
ENST00000261366
,
ENSG00000113368
PRO
P20700
Pharos - Targets
P20700
Orphanet
16365
PDB
3UMN
,
3TYY
,
7DTG
,
5BNW
,
3JT0
,
5VVX
,
2KPW
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02545 LMNA
3
LMNA(1-646) [nuclear envelope]
(R-HSA-535479)
LMNA(1-567)-RAF1(279-648) fusion [cytosol]
(R-HSA-6802399)
LMNA(1-567)-p-RAF1(279-648) fusion [cytosol]
(R-HSA-6802537)
0.933
23
UniProt:Q03252 LMNB2
0.85
8
UniProt:P52294 KPNA1
2
KPNA1 [cytosol]
(R-HSA-180612)
KPNA1 [nucleoplasm]
(R-HSA-188865)
0.742
5
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.706
21
UniProt:P02545-1 LMNA
7
p-S22, S392-LMNA-1 [nucleoplasm]
(R-HSA-8868349)
p-S22, S395-LMNA-1 [nucleoplasm]
(R-HSA-5229021)
p-S395-LMNA-1 [nucleoplasm]
(R-HSA-5228743)
LMNA-1 [cytosol]
(R-HSA-2995371)
LMNA(231-664) [nuclear envelope]
(R-HSA-352249)
LMNA(1-230) [nuclear envelope]
(R-HSA-352253)
Lamin A [nucleoplasm]
(R-HSA-264866)
0.677
5
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [cytosol]
(R-HSA-5205651)
0.675
14
UniProt:O60684 KPNA6
2
KPNA6 [nucleoplasm]
(R-HSA-9734665)
KPNA6 [cytosol]
(R-HSA-9734672)
0.666
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.623
4
UniProt:P02545-2 LMNA
5
LMNA-2 [nuclear envelope]
(R-HSA-912378)
p-S22, S395-LMNA-2 [nucleoplasm]
(R-HSA-5229019)
p-S395-LMNA-2 [nucleoplasm]
(R-HSA-5228740)
Lamin C [nucleoplasm]
(R-HSA-264872)
LMNA-2 [cytosol]
(R-HSA-2995387)
0.601
19
UniProt:O95295 SNAPIN
2
SNAPIN [Golgi membrane]
(R-HSA-434344)
SNAPIN [cytoplasmic vesicle membrane]
(R-HSA-434204)
0.556
3
UniProt:Q9NPF5 DMAP1
1
DMAP1 [nucleoplasm]
(R-HSA-212166)
0.556
3
UniProt:A6NC98 CC88B
0.556
3
UniProt:Q9H3R5 CENPH
2
CENPH [nucleoplasm]
(R-HSA-606314)
CENPH [cytosol]
(R-HSA-375294)
0.556
3
UniProt:Q96KQ4 PPP1R13B
1
PPP1R13B [nucleoplasm]
(R-HSA-6799775)
0.556
3
UniProt:O15131 KPNA5
2
KPNA5 [nucleoplasm]
(R-HSA-1176068)
KPNA5 [cytosol]
(R-HSA-1176062)
0.556
3
UniProt:Q7KZS0 Q7KZS0
0.556
3
UniProt:Q8WWB5 PIHD2
0.556
3
UniProt:Q8TC57 M1AP
0.556
3
UniProt:Q9Y6X4 FAM169A
1
FAM169A [cytosol]
(R-HSA-9715125)
0.556
3
UniProt:Q05BL1 Q05BL1
0.556
3
UniProt:Q05322 VP24
0.499
6
UniProt:P36956-PRO_0000314029 SREBF1
0.489
2
UniProt:P06748 NPM1
11
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1 [granular component]
(R-HSA-9017702)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
0.483
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text