Reactome | GPI-MELTF [plasma membrane]

GPI-MELTF [plasma membrane]

Stable Identifier

R-HSA-8940716

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

fullName evidence="8"Melanotransferrin, TRFM_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P08582 MELTF

Gene Names

MELTF, MAP97, MFI2

Chain

signal peptide:1-19, chain:20-709, propeptide:710-738

Reference Genes

COSMIC (genes):MELTF MELTF

dbSNP Gene:4241 MELTF

ENSEMBL:ENSG00000163975 MELTF

Participates

as a member of

GPI-anchored proteins [plasma membrane] (Homo sapiens)

Other forms of this molecule

cleaved GPI-MELTF [extracellular region]

p-MELTF [endoplasmic reticulum lumen]

MELTF [endoplasmic reticulum lumen]

Inferred To

Tsf3 [plasma membrane] (Drosophila melanogaster)

GPI-MELTF [plasma membrane] (Drosophila melanogaster)

GPI-MELTF [plasma membrane] (Gallus gallus)

GPI-MELTF [plasma membrane] (Mus musculus)

Meltf [plasma membrane] (Rattus norvegicus)

MELTF [plasma membrane] (Bos taurus)

MELTF [plasma membrane] (Canis familiaris)

MELTF [plasma membrane] (Sus scrofa)

Homologues of GPI-MELTF [plasma membrane] (Drosophila melanogaster)

otomp [plasma membrane] (Danio rerio)

Tsf1 [plasma membrane] (Drosophila melanogaster)

Modified Residues

Name

L-cysteine amide (GPI-anchor amidated amino acid carboxyl end residue(1−)) at 709

Coordinate

709

Modification

GPI-anchor amidated amino acid carboxyl end residue(1−)

PsiMod Name

L-cysteine amide

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to L-cysteine amide.

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.547	7

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