Reactome | DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol]

DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol]

Stable Identifier

R-HSA-9711962

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Dynactin subunit 1, DCTN1_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
26062823	STUMP un"stumped": anti-tumor response to anaplastic lymphoma kinase (ALK) inhibitor based targeted therapy in uterine inflammatory myofibroblastic tumor with myxoid features harboring DCTN1-ALK fusion Ali, SM, Patel, S, McMahon, C, Ross, JS, Ganeshan, DM, Brennan, T, Levenback, CF, Elvin, JA, Subbiah, V, Mayfield, J, Silva, EG, Ohaji, C, Stephens, PJ, Zinner, R, Miller, VA, Chmielecki, J, Berry, J, Chalmers, ZR, Subbiah, IM, Anand, D	J Hematol Oncol	2015
27874193	ALK oncoproteins in atypical inflammatory myofibroblastic tumours: novel RRBP1-ALK fusions in epithelioid inflammatory myofibroblastic sarcoma Fletcher, JA, Hornick, JL, Lee, CT, Ou, WB, Mariño-Enríquez, A, Li, CF, Lee, JC, Zhu, MJ, Huang, HY	J. Pathol.	2017

External Reference Information

External Reference

UniProt:Q14203 DCTN1

Gene Names

DCTN1

Chain

chain:1-1278

Reference Genes

ENSEMBL:ENSG00000204843 DCTN1

Participates

as a component of

DCTN1(1-1177)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol]

DCTN1(1-599)-ALK(1058-1620) fusion [cytosol]

DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol]

DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol]

DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol]

DCTN1 [cytosol]

Modified Residues

Name

Insertion of residues 1058 to 1620 at 1178 from UniProt:Q9UM73 ALK

Coordinate

1178

Name

O4'-phospho-L-tyrosine at 1096

Coordinate

1096

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1278

Coordinate

1278

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1282

Coordinate

1282

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1283

Coordinate

1283

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1358

Coordinate

1358

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1507

Coordinate

1507

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1604

Coordinate

1604

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
inflammatory myofibroblastic tumor	DOID:0050905

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.9	9
UniProt:Q13561 DCTN2	1	DCTN2 [cytosol] (R-HSA-380302)	0.779	9
UniProt:P30622-1 CLIP1			0.76	7
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.725	6
UniProt:Q9UJW0 DCTN4	1	DCTN4 [cytosol] (R-HSA-2029070)	0.712	7
UniProt:O00399 DCTN6	1	DCTN6 [cytosol] (R-HSA-2029035)	0.712	8
UniProt:O75935 DCTN3	1	DCTN3 [cytosol] (R-HSA-380264)	0.712	7
UniProt:P61163 ACTR1A	1	ACTR1A [cytosol] (R-HSA-380258)	0.712	7
UniProt:Q9NZ32 ACTR10	4	ACTR10 [cytosol] (R-HSA-6801556) ACTR10 [ficolin-1-rich granule lumen] (R-HSA-6801072) ACTR10 [extracellular region] (R-HSA-6806245) ACTR10 [azurophil granule lumen] (R-HSA-6801080)	0.712	7
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.704	9
UniProt:P42025 ACTR1B	4	ACTR1B [cytosol] (R-HSA-2228745) ACTR1B [ficolin-1-rich granule lumen] (R-HSA-6801063) ACTR1B [extracellular region] (R-HSA-6806503) ACTR1B [secretory granule lumen] (R-HSA-6801082)	0.65	6
UniProt:P54256 HAP1			0.646	4
UniProt:P52907 CAPZA1	2	CAPZA1(265-276) [extracellular region] (R-HSA-879421) CAPZA1 [cytosol] (R-HSA-879363)	0.638	3
UniProt:Q96RK4 BBS4	1	BBS4 [cytosol] (R-HSA-5617635)	0.635	3
UniProt:Q14204 DYNC1H1	3	DYNC1H1 [cytosol] (R-HSA-380285) DYNC1H1 [azurophil granule lumen] (R-HSA-6799155) DYNC1H1 [extracellular region] (R-HSA-6806223)	0.615	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	10
UniProt:P47755 CAPZA2	2	CAPZA2(265-276) [extracellular region] (R-HSA-879417) CAPZA2 [cytosol] (R-HSA-879448)	0.615	6
UniProt:P30622 CLIP1	3	CLIP1(1-1083)-p-6Y LTK(488-864) fusion [plasma membrane] (R-HSA-9842573) CLIP1(1-1083)-LTK(488-864) fusion [plasma membrane] (R-HSA-9842572) CLIP1 [cytosol] (R-HSA-377732)	0.595	3
UniProt:Q9Z0Y1	1	Dctn3 [cytosol] (R-MMU-380264)	0.564	2
UniProt:Q99KJ8	1	Dctn2 [cytosol] (R-MMU-380302)	0.564	2
UniProt:O08788	1	Dctn1 [cytosol] (R-MMU-380301)	0.564	2
UniProt:Q9NRI5 DISC1			0.553	2
UniProt:Q9UNH7 SNX6			0.499	2
UniProt:Q7Z460 CLASP1	1	CLASP1 [cytosol] (R-HSA-376230)	0.483	3
UniProt:O75122 CLASP2	1	CLASP2 [cytosol] (R-HSA-376252)	0.483	2
UniProt:Q13409 DYNC1I2	1	DYNC1I2 [cytosol] (R-HSA-201607)	0.483	2
UniProt:Q9BTE1 DCTN5	1	DCTN5 [cytosol] (R-HSA-2029012)	0.483	5
UniProt:P43034 PAFAH1B1	1	PAFAH1B1 [cytosol] (R-HSA-376249)	0.48	2
UniProt:Q6DN90 IQEC1			0.471	2
UniProt:Q9JK25	1	Clip1 [cytosol] (R-RNO-377732)	0.463	2
UniProt:Q8TCX1 DYNC2LI1	2	DYNC2LI1 [ciliary tip] (R-HSA-5625333) DYNC2LI1 [cilium] (R-HSA-5624862)	0.462	2

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