Reactome | HSP90B1 [extracellular region]

HSP90B1 [extracellular region]

Stable Identifier

R-HSA-3221653

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Endoplasmin, ENPL_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P14625 HSP90B1

Gene Names

HSP90B1, GRP94, TRA1

Chain

signal peptide:1-21, chain:22-803

Reference Genes

BioGPS Gene:7184 HSP90B1

COSMIC (genes):HSP90B1 HSP90B1

CTD Gene:7184 HSP90B1

dbSNP Gene:7184 HSP90B1

ENSEMBL:ENSG00000166598 HSP90B1

HGNC:12028 HSP90B1

KEGG Gene (Homo sapiens):7184 HSP90B1

Monarch:7184 HSP90B1

NCBI Gene:7184 HSP90B1

OMIM:191175 HSP90B1

Reference Transcript

RefSeq:NM_003299.2 HSP90B1

Other Identifiers

0006550138

11741912_a_at

11741913_s_at

11752967_x_at

11753260_x_at

11754606_a_at

11754607_s_at

11754608_x_at

16756078

200598_s_at

200599_s_at

216449_3p_x_at

216449_x_at

2346499

2346503

3429313

3429314

3429316

3429318

3429319

3429320

3429323

3429325

3429326

3429327

3429329

3429330

3429331

3429332

3429335

3429339

3429341

3429343

3429344

3429346

3429347

3429348

3611056

3611061

3611062

3611065

3611071

442_at

7184

7958130

A_23_P2601

GE79080

GO:0000166

GO:0001666

GO:0002224

GO:0003674

GO:0003723

GO:0005509

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005783

GO:0005788

GO:0005789

GO:0005829

GO:0005886

GO:0005925

GO:0006457

GO:0006464

GO:0006810

GO:0006898

GO:0006950

GO:0007010

GO:0007165

GO:0008150

GO:0008219

GO:0009056

GO:0015031

GO:0016020

GO:0016192

GO:0016529

GO:0019221

GO:0019899

GO:0019903

GO:0022607

GO:0030433

GO:0030496

GO:0030970

GO:0031012

GO:0031247

GO:0031410

GO:0032991

GO:0033018

GO:0034663

GO:0034975

GO:0034976

GO:0036500

GO:0042470

GO:0042592

GO:0043066

GO:0043167

GO:0043226

GO:0043666

GO:0043687

GO:0044267

GO:0048471

GO:0050750

GO:0051082

GO:0051208

GO:0062023

GO:0070062

GO:0071318

GO:0071682

Hs.288528.0.S1_3p_s_at

Hs.82689.0.S1_3p_a_at

ILMN_1686328

ILMN_2096116

PH_hs_0022928

TC12000803.hg

X15187_at

g4507676_3p_a_at

Participant Of

hasMember

Ligands of MSR1 [extracellular region]

Other forms of this molecule

HSP90B1 [endocytic vesicle lumen]

p-HSP90B1 [endoplasmic reticulum lumen]

HSP90B1 [endoplasmic reticulum lumen]

Inferred To

HSP90B1 [extracellular region] (Canis familiaris)

HSP90B1 [extracellular region] (Gallus gallus)

HSP90B1 [extracellular region] (Xenopus tropicalis)

Hsp90b1 [extracellular region] (Mus musculus)

Hsp90b1 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_003290.1

ZINC - Investigational

ENPL_HUMAN

Target Pathogen

5b354852be737e166372e9ad, 5b354852be737e166372e994

OpenTargets

ENSG00000166598

HPA

ENSG00000166598-HSP90B1

GeneCards

P14625

ZINC - Substances

ENPL_HUMAN

ZINC target

P14625

Ensembl

ENST00000299767, ENSG00000166598, ENSP00000299767

PRO

P14625

ZINC - Predictions - Purchasable

ENPL_HUMAN

PDB

4NH9

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q00597 FANCC	1	FANCC [nucleoplasm] (R-HSA-419530)	0.581	4
UniProt:P11021 HSPA5	6	HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.564	2
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.462	4

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