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SMC4 [cytosol]
Stable Identifier
R-HSA-2517876
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Structural maintenance of chromosomes protein 4, SMC protein 4, SMC-4, Chromosome-associated polypeptide C, hCAP-C, XCAP-C homolog, CAPC, SMC4L1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
Condensation of Prometaphase Chromosomes (Homo sapiens)
CDK1 phosphorylates condensin I (Homo sapiens)
CDK1 Phosphorylated Condensin I [cytosol] (Homo sapiens)
SMC4 [cytosol] (Homo sapiens)
Condensin I [cytosol] (Homo sapiens)
SMC4 [cytosol] (Homo sapiens)
CK2 phosphorylates condensin I subunits (Homo sapiens)
Condensin I [cytosol] (Homo sapiens)
SMC4 [cytosol] (Homo sapiens)
Dephosphorylation of CK2-modified condensin I (Homo sapiens)
Condensin I [cytosol] (Homo sapiens)
SMC4 [cytosol] (Homo sapiens)
Phosphorylated condensin I promotes condensation of prometaphase chromosomes (Homo sapiens)
CDK1 Phosphorylated Condensin I [cytosol] (Homo sapiens)
SMC4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NTJ3 SMC4
Gene Names
SMC4, CAPC, SMC4L1
Chain
chain:1-1288
Reference Genes
BioGPS Gene:10051 SMC4
COSMIC (genes):SMC4 SMC4
CTD Gene:10051 SMC4
dbSNP Gene:10051 SMC4
ENSEMBL:ENSG00000113810 SMC4
ENSEMBL_homo_sapiens_GENE:ENSG00000113810.16 SMC4
HGNC:14013 SMC4
KEGG Gene (Homo sapiens):10051 SMC4
Monarch:10051 SMC4
NCBI Gene:10051 SMC4
OMIM:605575 SMC4
UCSC:Q9NTJ3 SMC4
Reference Transcript
RefSeq:NM_005496.3 SMC4
RefSeq:NM_001288753.1 SMC4
RefSeq:XM_011512311.2 SMC4
RefSeq:NM_001002800.2 SMC4
Other Identifiers
10051
11733874_a_at
11733875_a_at
11733876_x_at
11754320_a_at
16947556
201663_PM_s_at
201663_s_at
201664_PM_at
201664_at
2650201
2650202
2650203
2650204
2650205
2650206
2650207
2650208
2650209
2650210
2650211
2650212
2650213
2650215
2650216
2650217
2650219
2650220
2650227
2650228
2650229
2650232
2650235
2650237
2650240
2650242
2650244
2650245
2650246
2650247
2650248
2650249
2650252
2650254
2650255
2650256
2650258
2650259
2650261
2650262
2650263
2650264
34878_at
44051_at
8083709
A_14_P112145
A_14_P117098
A_23_P91900
A_33_P3248519
A_33_P3716128
GE56658
GO:0000070
GO:0000166
GO:0000228
GO:0000278
GO:0000775
GO:0000794
GO:0000796
GO:0003677
GO:0003682
GO:0003697
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0007049
GO:0007059
GO:0007076
GO:0010032
GO:0016607
GO:0016787
GO:0016887
GO:0022414
GO:0030261
GO:0043226
GO:0045132
GO:0051276
GO:0051301
GO:0051383
GO:0051984
GO:0140013
GO:0140014
GO:0140657
GO:1905820
GO:1905821
HMNXSV003024933
ILMN_1683302
ILMN_2251804
ILMN_2330861
PH_hs_0003499
PH_hs_0032198
TC03000873.hg
g4885112_3p_a_at
g6807670_3p_at
Participates
as a component of
CDK1 Phosphorylated Condensin I [cytosol] (Homo sapiens)
Condensin I [cytosol] (Homo sapiens)
Other forms of this molecule
SMC4 [nucleoplasm]
p-S-SMC4 [cytosol]
Inferred To
Smc4 [cytosol]
(Rattus norvegicus)
SMC4 [cytosol]
(Bos taurus)
SMC4 [cytosol]
(Canis familiaris)
SMC4 [cytosol]
(Gallus gallus)
SMC4 [cytosol]
(Mus musculus)
SMC4 [cytosol]
(Sus scrofa)
Ghost homologue of SMC4 [cytosol]
(Dictyostelium discoideum)
Ghost homologue of SMC4 [cytosol]
(Drosophila melanogaster)
Ghost homologue of SMC4 [cytosol]
(Plasmodium falciparum)
Ghost homologue of SMC4 [cytosol]
(Saccharomyces cerevisiae)
Ghost homologue of SMC4 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001002800.1
,
XP_011510613.1
,
NP_005487.3
,
NP_001275682.1
OpenTargets
ENSG00000113810
HPA
ENSG00000113810-SMC4
GeneCards
Q9NTJ3
Ensembl
ENST00000462787
,
ENSP00000349961
,
ENSP00000341382
,
ENST00000357388
,
ENSP00000420734
,
ENSG00000113810
,
ENST00000344722
PRO
Q9NTJ3
Pharos - Targets
Q9NTJ3
PDB
4U4P
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.669
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
11
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