Reactome | LAMB3 [extracellular region]

LAMB3 [extracellular region]

Stable Identifier

R-HSA-445992

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Laminin beta-3

Locations in the PathwayBrowser

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Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Type I hemidesmosome assembly (Homo sapiens)
    - BP180 interacts extracellularly with Laminin 332 (Homo sapiens)
      - Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Laminin-332 [extracellular region] (Homo sapiens)
        
        LAMB3 [extracellular region] (Homo sapiens)
      - Laminin-332 [extracellular region] (Homo sapiens)
        
        LAMB3 [extracellular region] (Homo sapiens)
    - BP230 interacts with keretin K5/K14 (Homo sapiens)
      - CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin [plasma membrane] (Homo sapiens)
        
        BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Laminin-332 [extracellular region] (Homo sapiens)
        
        LAMB3 [extracellular region] (Homo sapiens)
      - Type II hemidesmosome [plasma membrane] (Homo sapiens)
        
        CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin [plasma membrane] (Homo sapiens)
        
        BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Laminin-332 [extracellular region] (Homo sapiens)
        
        LAMB3 [extracellular region] (Homo sapiens)
    - BP230 is recruited to the hemidesmosome (Homo sapiens)
      - BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Laminin-332 [extracellular region] (Homo sapiens)
        
        LAMB3 [extracellular region] (Homo sapiens)
      - Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Laminin-332 [extracellular region] (Homo sapiens)
        
        LAMB3 [extracellular region] (Homo sapiens)
    - CD151 interacts with BP180 and the integrin alpha 6 subunit (Homo sapiens)
      - BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Laminin-332 [extracellular region] (Homo sapiens)
        
        LAMB3 [extracellular region] (Homo sapiens)
      - CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin [plasma membrane] (Homo sapiens)
        
        BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Laminin-332 [extracellular region] (Homo sapiens)
        
        LAMB3 [extracellular region] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by MET (Homo sapiens)
    - MET promotes cell motility (Homo sapiens)
      - MET activates PTK2 signaling (Homo sapiens)
        
        PTK2 binds activated MET (Homo sapiens)
        
        Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Homo sapiens)
        
        Collagen, laminin, fibronectin [extracellular region] (Homo sapiens)
        
        Laminins [extracellular region] (Homo sapiens)
        
        Laminin-332 [extracellular region] (Homo sapiens)
        
        LAMB3 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13751 LAMB3

Gene Names

LAMB3, LAMNB1

Chain

signal peptide:1-17, chain:18-1172

Reference Genes

BioGPS Gene:3914 LAMB3

COSMIC (genes):LAMB3 LAMB3

CTD Gene:3914 LAMB3

dbSNP Gene:3914 LAMB3

ENSEMBL:ENSG00000196878 LAMB3

HGNC:6490 LAMB3

KEGG:hsa:3914 LAMB3

Monarch:3914 LAMB3

NCBI Gene:3914 LAMB3

OMIM:150310 LAMB3

UCSC:Q13751 LAMB3

Reference Transcript

Other Identifiers

11719487_a_at

11752302_a_at

16698883

209270_PM_at

209270_at

2453794

2453795

2453796

2453797

2453798

2453799

2453800

2453802

2453803

2453804

2453807

2453809

2453810

2453811

2453812

2453815

2453816

2453817

2453820

2453822

2453823

2453824

2453826

2453827

2453828

2453830

2453831

2453835

2453836

2453837

2453838

2453839

2453840

2453842

2453843

36929_at

3914

7924029

A_23_P86012

A_33_P3338121

GE60528

GE84101

GO:0005198

GO:0005201

GO:0005515

GO:0005576

GO:0005604

GO:0005610

GO:0007155

GO:0008544

GO:0009887

GO:0009888

GO:0016477

GO:0030154

GO:0030198

GO:0030312

GO:0031012

GO:0034446

GO:0035987

GO:0043256

GO:0044877

GO:0048856

GO:0048870

GO:0050873

GO:0062023

GO:0070831

HMNXSV003054231

ILMN_1680054

ILMN_1715684

ILMN_1800142

PH_hs_0020618

TC01003784.hg

U17760_rna1_at

g510702_3p_at

Participates

as a component of

Laminin-332 [extracellular region] (Homo sapiens)

Other forms of this molecule

LAMB3(18-?) [extracellular region]

LAMB3(?-1172) [extracellular region]

Inferred To

MEGF6 [extracellular region] (Bos taurus)

MEGF6 [extracellular region] (Canis familiaris)

MEGF6 [extracellular region] (Sus scrofa)

Megf6 [extracellular region] (Mus musculus)

Megf6 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_001121113.1, NP_001017402.1, XP_005273181.1, NP_000219.2

ENSEMBL

ENST00000356082, ENSP00000348384, ENST00000391911, ENST00000367030, ENSP00000355997, ENSP00000375778

OpenTargets

ENSG00000196878

HPA

ENSG00000196878-LAMB3

PRO

Q13751

Pharos - Targets

Q13751

GlyGen

Q13751

Orphanet

LAMB3

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.527	10

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