Reactome | HNRNPA1 [nucleoplasm]

HNRNPA1 [nucleoplasm]

Stable Identifier

R-HSA-71927

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

hnRNP A1, ROA1_HUMAN, Heterogeneous nuclear ribonucleoprotein A1, Helix-destabilizing protein, Single-strand binding protein, hnRNP core protein A1

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Homo sapiens)

- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - Formation of pre-mRNPs (Homo sapiens)
    - Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
      - shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
      - Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
  - mRNA Splicing (Homo sapiens)
    - mRNA Splicing - Major Pathway (Homo sapiens)
      - Formation of the Spliceosomal A complex (Homo sapiens)
        
        Spliceosomal A complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal E complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal B complex (Homo sapiens)
        
        Spliceosomal B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal B* complex (Homo sapiens)
        
        Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Bact complex (Homo sapiens)
        
        Spliceosomal B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal C* complex (Homo sapiens)
        
        Spliceosomal C complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal E complex (Homo sapiens)
        
        Spliceosomal E complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
        
        Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal P complex [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Pre-B complex (Homo sapiens)
        
        Spliceosomal A complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
      - Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
        
        Spliceosomal P complex [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPA1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P09651 HNRNPA1

Gene Names

HNRNPA1, HNRPA1

Chain

initiator methionine:1, chain:1-372, chain:2-372

Reference Genes

BioGPS Gene:3178 HNRNPA1

COSMIC (genes):HNRNPA1 HNRNPA1

CTD Gene:3178 HNRNPA1

dbSNP Gene:3178 HNRNPA1

ENSEMBL:ENSG00000135486.19 HNRNPA1

HGNC:5031 HNRNPA1

KEGG Gene (Homo sapiens):3178 HNRNPA1

Monarch:3178 HNRNPA1

NCBI Gene:3178 HNRNPA1

OMIM:164017 HNRNPA1

UCSC:P09651 HNRNPA1

Reference Transcript

Other Identifiers

11719462_x_at

11753459_x_at

11757268_x_at

11757837_x_at

11760085_s_at

16653915

16653917

16653919

16653935

17121398

18670819

18670826

18670828

18670829

18670830

18670831

18670832

18670833

200016_PM_x_at

200016_x_at

213356_PM_x_at

213356_x_at

214280_PM_x_at

214280_x_at

221919_PM_at

221919_at

222040_PM_at

222040_at

2419664

2476772

2522587

2522588

2522590

2522594

2556148

2587727

2864551

2864554

2864559

2864560

2899946

2903184

3011012

3011016

3011024

3142600

3142601

31463_s_at

3149421

3178

3189273

3390725

3416482

3416484

3416485

3416487

3416488

3416489

3416490

3416491

3416492

3416494

3416496

3416498

3416499

3416500

3416501

3416502

3416503

3416504

3416505

3416506

3490721

3490722

3490724

3490732

3490734

3490736

34987_s_at

3588454

3660444

3660446

3660447

3660448

3660449

3660450

3660451

3660454

3660455

3692695

3803380

3803384

3803386

3803388

3803390

3803392

3803394

3803396

3851113

3851115

3851117

3851119

3851121

3851123

3851125

3988734

4015535

4015537

40211_at

67592_f_at

78639_at

7892556

7893164

7894307

7895274

7895520

7895532

7895606

7896111

7896184

7896228

7896384

7896421

7916562

7955890

7995574

8022814

8034313

A_24_P454313

A_32_P19431

A_32_P8015

A_33_P3384260

GE83213

GO:0000381

GO:0000398

GO:0003676

GO:0003677

GO:0003697

GO:0003723

GO:0003727

GO:0003730

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005681

GO:0005737

GO:0005829

GO:0006397

GO:0006405

GO:0006913

GO:0008380

GO:0016020

GO:0016071

GO:0019904

GO:0032200

GO:0032211

GO:0032212

GO:0035198

GO:0036002

GO:0042149

GO:0042802

GO:0043226

GO:0043232

GO:0043484

GO:0051028

GO:0051168

GO:0051170

GO:0051179

GO:0060090

GO:0061752

GO:0070062

GO:0071013

GO:0098505

GO:0140693

GO:1903936

GO:1990000

GO:1990904

HMNXSV003023689

HMNXSV003029868

HMNXSV003052864

HMNXSV003055191

HMNXSV003058116

Hs.249495.3.S1_3p_a_at

Hs.249495.3.S1_3p_x_at

Hs.249495.4.S1_3p_at

ILMN_1661346

ILMN_1663447

ILMN_1815882

PH_hs_0029874

PH_hs_0036053

PH_hs_0037247

TC12000461.hg

TC12002381.hg

TC16001556.hg

U00947_s_at

X04347_s_at

X12671_rna1_at

X79536_at

g4504444_3p_x_at

Participates

as a component of

as an input of

PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Homo sapiens)

as a member of

shuttling HNRNPs [nucleoplasm] (Homo sapiens)

Other forms of this molecule

HNRNPA1 [cytosol]

Inferred To

hrp-1 [nucleoplasm] (Caenorhabditis elegans)

hnrnpa1 [nucleoplasm] (Xenopus tropicalis)

Hnrnpa1 [nucleoplasm] (Mus musculus)

Hnrnpa1 [nucleoplasm] (Rattus norvegicus)

Homologues of HNRNPA1 [nucleoplasm] (Caenorhabditis elegans)

Homologues of HNRNPA1 [nucleoplasm] (Danio rerio)

HNRNPA1 [nucleoplasm] (Bos taurus)

HNRNPA1 [nucleoplasm] (Caenorhabditis elegans)

HNRNPA1 [nucleoplasm] (Canis familiaris)

HNRNPA1 [nucleoplasm] (Danio rerio)

HNRNPA1 [nucleoplasm] (Gallus gallus)

HNRNPA1 [nucleoplasm] (Sus scrofa)

sqd-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_002127.1, NP_112420.1, XP_005268883.1

OpenTargets

ENSG00000135486

ZINC - Substances

ROA1_HUMAN

GeneCards

P09651

HPA

ENSG00000135486-HNRNPA1

Ensembl

ENSP00000446486, ENSG00000135486, ENST00000340913, ENSP00000341826, ENST00000547276, ENSP00000503610, ENSP00000447260, ENST00000546500, ENST00000677210, ENST00000547566, ENSP00000449913, ENSP00000448617, ENST00000550482

ZINC - Biogenic

ROA1_HUMAN

ZINC target

P09651

PRO

P09651

Pharos - Targets

P09651

Orphanet

22023

PDB

1U1N, 1UP1, 1U1O, 1U1M, 5MPL, 5ZGL, 1U1L, 2UP1, 1U1K, 7BX7, 6J60, 4YOE, 1PO6, 5MPG, 5ZGD, 6BXX, 2LYV, 1HA1, 1U1R, 1L3K, 1U1P, 1PGZ, 6DCL, 2H4M, 1U1Q

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.839	9
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.669	3
UniProt:P31942 HNRH3			0.659	3
UniProt:P38919 EIF4A3	2	EIF4A3 [cytosol] (R-HSA-927868) EIF4A3 [nucleoplasm] (R-HSA-8849149)	0.643	3
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.602	3
UniProt:P27958-PRO_0000037577			0.599	4
UniProt:Q5BKZ1 ZN326			0.597	4
UniProt:P51991 HNRNPA3	1	HNRNPA3 [nucleoplasm] (R-HSA-71931)	0.564	2
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [extracellular exosome] (R-HSA-8950304) HNRNPA2B1 [nucleoplasm] (R-HSA-71929)	0.564	2
UniProt:P38159 RBMX	2	RBMX [cytosol] (R-HSA-9715135) RBMX [nucleoplasm] (R-HSA-71939)	0.527	2
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.527	2
UniProt:P43243 MATR3			0.527	2
UniProt:P23246 SFPQ	3	SFPQ [cytosol] (R-HSA-9635505) p-Y-SFPQ [nucleoplasm] (R-HSA-8849461) SFPQ [nucleoplasm] (R-HSA-3900138)	0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.527	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.524	2
UniProt:Q14141 SEPT6			0.499	3
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.462	3
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.462	3
IntAct:EBI-6857440 NS3			0.462	2
UniProt:O60477 BRNP1			0.462	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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