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DOCK7 [cytosol]
Stable Identifier
R-HSA-1012970
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Dedicator of cytokinesis protein 7, DOCK7_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
DOCKs bind to RhoGEFs (Homo sapiens)
DOCK-GEFs [cytosol] (Homo sapiens)
DOCK7 [cytosol] (Homo sapiens)
DOCK-GEFs:RAC1, CDC42 [cytosol] (Homo sapiens)
DOCK-GEFs [cytosol] (Homo sapiens)
DOCK7 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by MET (Homo sapiens)
MET promotes cell motility (Homo sapiens)
MET activates RAP1 and RAC1 (Homo sapiens)
CRK,CRKL recruits RAC1 GEF to activated MET (Homo sapiens)
(DOCK7) [cytosol] (Homo sapiens)
DOCK7 [cytosol] (Homo sapiens)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Homo sapiens)
(DOCK7) [cytosol] (Homo sapiens)
DOCK7 [cytosol] (Homo sapiens)
DOCK7 activates RAC1 (Homo sapiens)
(DOCK7) [cytosol] (Homo sapiens)
DOCK7 [cytosol] (Homo sapiens)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Homo sapiens)
(DOCK7) [cytosol] (Homo sapiens)
DOCK7 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
DOCK7 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
DOCK7 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96N67 DOCK7
Gene Names
DOCK7, KIAA1771
Chain
chain:1-2140
Reference Genes
BioGPS Gene:85440 DOCK7
COSMIC (genes):DOCK7 DOCK7
CTD Gene:85440 DOCK7
dbSNP Gene:85440 DOCK7
ENSEMBL:ENSG00000116641 DOCK7
HGNC:19190 DOCK7
KEGG:hsa:85440 DOCK7
Monarch:85440 DOCK7
NCBI Gene:85440 DOCK7
OMIM:615730 DOCK7
UCSC:Q96N67 DOCK7
Reference Transcript
RefSeq:NM_001272002.1 DOCK7
RefSeq:NM_001330614.1 DOCK7
RefSeq:NM_033407.3 DOCK7
RefSeq:NM_001272001.1 DOCK7
RefSeq:NM_001272000.1 DOCK7
RefSeq:NM_001271999.1 DOCK7
RefSeq:XM_011542326.2 DOCK7
Other Identifiers
11739883_a_at
11739884_a_at
11739885_s_at
11749664_a_at
11749665_x_at
11753987_x_at
11763209_at
1562940_PM_at
1562940_at
16688024
225384_PM_at
225384_at
237470_PM_at
237470_at
2415911
2415912
2415913
2415914
2415915
2415916
2415917
2415919
2415920
2415921
2415922
2415923
2415924
2415925
2415926
2415927
2415928
2415929
2415930
2415932
2415933
2415934
2415935
2415936
2415937
2415938
2415939
2415940
2415941
2415942
2415944
2415945
2415946
2415947
2415948
2415949
2415950
2415951
2415952
2415953
2415954
2415956
2415957
2415959
2415964
2415965
2415966
2415967
2415968
2415970
2415971
2415972
2415975
2415976
2415977
2415978
2415979
2415980
2415981
2415983
2415987
2415988
2415989
2415990
2415991
2415992
2415993
2415994
2415995
2415996
2415997
2415998
2415999
2416005
2416006
2416007
2416008
2416009
2416010
2416011
2416014
2416015
242611_PM_at
242611_at
48708_at
49128_i_at
49129_r_at
7916669
85440
A_23_P331348
A_24_P203622
A_32_P230547
GE566028
GE623733
GE85506
GO:0000226
GO:0005085
GO:0005515
GO:0005925
GO:0007010
GO:0007163
GO:0007264
GO:0007399
GO:0007409
GO:0008180
GO:0022027
GO:0030154
GO:0030424
GO:0030426
GO:0031175
GO:0031267
GO:0033138
GO:0042995
GO:0043005
GO:0045178
GO:0045200
GO:0048856
GO:0050767
GO:0090630
GO:0098772
GO:0120163
GO:1904754
HMNXSV003005424
HMNXSV003013615
Hs.22869.0.A1_3p_at
Hs.244818.0.A1_3p_at
Hs.93560.0.S1_3p_at
Hs2.348437.1.S1_3p_at
ILMN_1678629
ILMN_2152387
PH_hs_0041018
TC01002727.hg
Participates
as a candidate of
CDC42 GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
DOCK-GEFs [cytosol] (Homo sapiens)
(DOCK7) [cytosol] (Homo sapiens)
Inferred To
Dock7 [cytosol]
(Mus musculus)
Dock7 [cytosol]
(Rattus norvegicus)
DOCK7 [cytosol]
(Bos taurus)
DOCK7 [cytosol]
(Caenorhabditis elegans)
DOCK7 [cytosol]
(Canis familiaris)
DOCK7 [cytosol]
(Gallus gallus)
DOCK7 [cytosol]
(Sus scrofa)
dock7 [cytosol]
(Xenopus tropicalis)
zizB [cytosol]
(Dictyostelium discoideum)
Zir [cytosol]
(Drosophila melanogaster)
Cross References
OpenTargets
ENSG00000116641
ENSEMBL
ENST00000251157
,
ENST00000404627
,
ENST00000635253
,
ENST00000634264
,
ENST00000635123
,
ENSP00000413583
,
ENSP00000340742
,
ENST00000340370
,
ENSP00000489124
,
ENSP00000489499
,
ENSP00000489284
,
ENSP00000251157
,
ENSP00000384446
,
ENST00000454575
HPA
ENSG00000116641-DOCK7
PRO
Q96N67
Pharos - Targets
Q96N67
Orphanet
DOCK7
GlyGen
Q96N67
PDB
6AJ4
,
6AJL
HMDB Protein
HMDBP08358
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
13
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.615
3
UniProt:Q9UM54 MYO6
3
MYO6 [plasma membrane]
(R-HSA-3006691)
MYO6 [lysosomal membrane]
(R-HSA-3006694)
MYO6 [cytosol]
(R-HSA-3006692)
0.569
3
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.569
4
UniProt:Q9Y3M2 CBY1
3
CBY1 [nucleoplasm]
(R-HSA-3769210)
pS20-CBY1 [nucleoplasm]
(R-HSA-3769356)
pS20-CBY1 [cytosol]
(R-HSA-3769354)
0.508
2
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.483
3
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