Reactome | RPL21 [cytosol]

RPL21 [cytosol]

Stable Identifier

R-HSA-72426

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

60S ribosomal protein L21, P46778

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL21 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL21 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL21 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL21 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL21 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL21 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL21 [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - Influenza Viral RNA Transcription and Replication (Homo sapiens)
        
        Viral mRNA Translation (Homo sapiens)
        
        Synthesis of PB1-F2 (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL21 [cytosol] (Homo sapiens)
        
        Viral Protein Synthesis (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL21 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL21 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL21 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL21 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL21 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL21 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL21 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL21 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL21 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL21 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL21 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P46778 RPL21

Gene Names

RPL21

Chain

initiator methionine:, chain:2-160

Reference Genes

BioGPS Gene:6144 RPL21

COSMIC (genes):RPL21 RPL21

CTD Gene:6144 RPL21

dbSNP Gene:6144 RPL21

ENSEMBL:ENSG00000122026 RPL21

HGNC:10313 RPL21

KEGG:hsa:6144 RPL21

Monarch:6144 RPL21

NCBI Gene:6144 RPL21

OMIM:603636 RPL21

UCSC:P46778 RPL21

Reference Transcript

RefSeq:NM_000982.3 RPL21

Other Identifiers

11753680_x_at

11755203_x_at

16719008

16773473

16773478

16773485

16773491

200012_PM_x_at

200012_x_at

2324529

2324531

2454592

2454593

2555855

2555857

2699539

2720538

2723714

2769515

2785024

2792397

2897332

2982245

2991784

2991785

3220079

3220081

32337_at

3263507

3282866

3309937

3309938

3309939

3309940

3319995

3420401

3423146

3423148

3423150

3423151

3473356

3482820

3482821

3482822

3482823

3482825

3482826

3482829

3482830

3482831

3482832

3482833

3482834

3482835

3482836

3482837

3482838

3482839

3482840

3482842

3568794

3627018

3634803

3679669

3679670

3679671

3714829

3714831

3800707

3800710

3982151

3984756

6144

7892680

7893259

7894125

7896036

7924144

7936727

7968226

7968232

7968234

7999360

8131661

A_14_P200364

A_19_P00807415

A_21_P0000262

A_23_P2725

A_32_P234738

GE80973

GE85909

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005737

GO:0005783

GO:0005829

GO:0005840

GO:0006412

GO:0016020

GO:0022625

GO:0022626

GO:0043226

GO:0045202

GO:1990904

HMNXSV003010154

HMNXSV003014280

HMNXSV003054397

HMNXSV003055480

ILMN_2290808

PH_hs_0029970

PH_hs_0033032

PH_hs_0038942

RNA33539|snoRNA_scaRNA_135_126

RNA33716|snoRNA_scaRNA_312_72

TC07002180.hg

TC13000073.hg

TC13000978.hg

U25789_at

Participates

as a component of

Inferred To

rpl-21 [cytosol] (Caenorhabditis elegans)

RPL21 [cytosol] (Bos taurus)

RPL21 [cytosol] (Gallus gallus)

RPL21 [cytosol] (Plasmodium falciparum)

RPL21 [cytosol] (Sus scrofa)

LOC106558335 [cytosol] (Canis familiaris)

Homologues of RPL21 [cytosol] (Schizosaccharomyces pombe)

RPL21A [cytosol] (Saccharomyces cerevisiae)

rpl2101 [cytosol] (Schizosaccharomyces pombe)

rpl2102 [cytosol] (Schizosaccharomyces pombe)

RpL21 [cytosol] (Drosophila melanogaster)

Rpl21 [cytosol] (Mus musculus)

LOC134480579 [cytosol] (Rattus norvegicus)

rpl21 [cytosol] (Danio rerio)

rpl21 [cytosol] (Dictyostelium discoideum)

rpl21 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_000973.2

OpenTargets

ENSG00000122026

ENSEMBL

ENSP00000370569, ENST00000319826, ENST00000326092, ENSP00000370574, ENST00000311549, ENSP00000346027, ENSP00000351021, ENST00000272274

HPA

ENSG00000122026-RPL21

PRO

P46778

Pharos - Targets

P46778

Orphanet

RPL21

GlyGen

P46778

PDB

8FKX, 8FKW, 8FL7, 8FL0, 8IDT, 6IP8, 8FL6, 6LQM, 8FKP, 6Y57, 8FKZ, 6ZME, 5T2C, 8OJ5, 8JDJ, 8JDL, 6OLF, 8G60, 8INE, 7XNX, 6OLE, 7QVP, 7BHP, 8Y0X, 7OW7, 8FLA, 8A3D, 6Y6X, 6OM0, 6Z6L, 8QFD, 6OLI, 8OJ8, 6ZMO, 8IFD, 8FLE, 8FL2, 8GLP, 7F5S, 8FL4, 8OJ0, 8FL3, 5AJ0, 6W6L, 8IPY, 6OM7, 8IE3, 4UG0, 8FKU, 8IR1, 8IR3, 8FKV, 8FL9, 8IDY, 6XA1, 8IPD, 6QZP, 6Y2L, 8FKY, 6IP6, 6IP5, 6ZMI, 8G5Y, 8Y0W, 6OLG, 8G5Z, 6LSR, 8JDK, 8INF, 6Z6M, 8JDM, 4V6X, 8FLB, 8FLD, 8INK, 7XNY, 6Y0G, 6LSS, 8FLC, 6Z6N, 8FKT, 8FKQ, 6ZM7, 8FKS, 6LU8, 8FKR, 8IPX, 8OHD, 8G6J, 5LKS, 8G61, 6OLZ, 8IFE, 8FLF

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	16
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.527	2

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