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CYR61 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-5173201
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
Protein CYR61, CYR61_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Post-translational protein phosphorylation (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
CYR61 [endoplasmic reticulum lumen] (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
CYR61 [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00622 CYR61
Gene Names
CYR61, CCN1, GIG1, IGFBP10
Chain
signal peptide:1-24, chain:25-381
Reference Genes
BioGPS Gene:3491 CYR61
COSMIC (genes):CCN1 CYR61
CTD Gene:3491 CYR61
dbSNP Gene:3491 CYR61
ENSEMBL:ENSG00000142871 CYR61
HGNC:2654 CYR61
KEGG:hsa:3491 CYR61
Monarch:3491 CYR61
NCBI Gene:3491 CYR61
OMIM:602369 CYR61
UCSC:O00622 CYR61
Reference Transcript
RefSeq:NM_001554.4 CYR61
Other Identifiers
11715493_a_at
11749905_a_at
16666738
201289_PM_at
201289_at
210764_PM_s_at
210764_s_at
2344891
2344892
2344893
2344894
2344895
2344896
2344897
2344898
2344899
2344900
2344901
2344902
2344903
2344904
2344905
2344906
2344907
2344908
2344909
3491
38772_at
7902687
A_14_P104240
A_23_P46426
A_23_P46429
A_24_P370946
GE81042
GO:0001649
GO:0001934
GO:0002041
GO:0003181
GO:0003278
GO:0003281
GO:0005178
GO:0005198
GO:0005201
GO:0005515
GO:0005576
GO:0005615
GO:0005788
GO:0006355
GO:0006915
GO:0006935
GO:0007155
GO:0007165
GO:0008201
GO:0010811
GO:0012501
GO:0019838
GO:0030154
GO:0030198
GO:0030312
GO:0030335
GO:0030501
GO:0030513
GO:0031012
GO:0033690
GO:0043065
GO:0043066
GO:0044319
GO:0045597
GO:0045669
GO:0045860
GO:0045944
GO:0048856
GO:0048870
GO:0050793
GO:0050840
GO:0060413
GO:0060591
GO:0060710
GO:0060716
GO:0061036
GO:0062023
GO:0070372
GO:0072593
GO:0098609
GO:2000304
HMNXSV003030900
ILMN_2188264
PH_hs_0000935
TC01000818.hg
U62015_at
g4504612_3p_at
g6649848_3p_a_at
Participates
as a member of
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
Other forms of this molecule
p-CYR61 [endoplasmic reticulum lumen]
Inferred To
CCN1 [endoplasmic reticulum lumen]
(Bos taurus)
CCN1 [endoplasmic reticulum lumen]
(Canis familiaris)
CCN1 [endoplasmic reticulum lumen]
(Gallus gallus)
CCN1 [endoplasmic reticulum lumen]
(Sus scrofa)
Ccn1 [endoplasmic reticulum lumen]
(Mus musculus)
Ccn1 [endoplasmic reticulum lumen]
(Rattus norvegicus)
ccn1 [endoplasmic reticulum lumen]
(Xenopus tropicalis)
Ccn [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENST00000451137
,
ENSP00000398736
,
ENSG00000142871
OpenTargets
ENSG00000142871
GeneCards
CCN1
HPA
ENSG00000142871-CCN1
PRO
O00622
Pharos - Targets
O00622
GlyGen
O00622
PDB
4D11
,
4D0Z
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60906 SMPD2
1
SMPD2 [plasma membrane]
(R-HSA-194337)
0.556
3
UniProt:P05090 APOD
1
APOD [extracellular region]
(R-HSA-5216199)
0.527
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.527
10
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