Reactome | CYR61 [endoplasmic reticulum lumen]

CYR61 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-5173201

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Protein CYR61, CYR61_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O00622 CYR61

Gene Names

CYR61, CCN1, GIG1, IGFBP10

Chain

signal peptide:1-24, chain:25-381

Reference Genes

BioGPS Gene:3491 CYR61

COSMIC (genes):CCN1 CYR61

CTD Gene:3491 CYR61

dbSNP Gene:3491 CYR61

ENSEMBL:ENSG00000142871 CYR61

HGNC:2654 CYR61

KEGG:hsa:3491 CYR61

Monarch:3491 CYR61

NCBI Gene:3491 CYR61

OMIM:602369 CYR61

UCSC:O00622 CYR61

Reference Transcript

RefSeq:NM_001554.4 CYR61

Other Identifiers

11715493_a_at

11749905_a_at

16666738

201289_PM_at

201289_at

210764_PM_s_at

210764_s_at

2344891

2344892

2344893

2344894

2344895

2344896

2344897

2344898

2344899

2344900

2344901

2344902

2344903

2344904

2344905

2344906

2344907

2344908

2344909

3491

38772_at

7902687

A_14_P104240

A_23_P46426

A_23_P46429

A_24_P370946

GE81042

GO:0001649

GO:0001934

GO:0002041

GO:0003181

GO:0003278

GO:0003281

GO:0005178

GO:0005198

GO:0005201

GO:0005515

GO:0005576

GO:0005615

GO:0005788

GO:0006355

GO:0006915

GO:0006935

GO:0007155

GO:0007165

GO:0008201

GO:0010811

GO:0012501

GO:0019838

GO:0030154

GO:0030198

GO:0030312

GO:0030335

GO:0030501

GO:0030513

GO:0031012

GO:0033690

GO:0043065

GO:0043066

GO:0044319

GO:0045597

GO:0045669

GO:0045860

GO:0045944

GO:0048856

GO:0048870

GO:0050793

GO:0050840

GO:0060413

GO:0060591

GO:0060710

GO:0060716

GO:0061036

GO:0062023

GO:0070372

GO:0072593

GO:0098609

GO:2000304

HMNXSV003030900

ILMN_2188264

PH_hs_0000935

TC01000818.hg

U62015_at

g4504612_3p_at

g6649848_3p_a_at

Participates

as a member of

FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

p-CYR61 [endoplasmic reticulum lumen]

Inferred To

CCN1 [endoplasmic reticulum lumen] (Bos taurus)

CCN1 [endoplasmic reticulum lumen] (Canis familiaris)

CCN1 [endoplasmic reticulum lumen] (Gallus gallus)

CCN1 [endoplasmic reticulum lumen] (Sus scrofa)

Ccn1 [endoplasmic reticulum lumen] (Mus musculus)

Ccn1 [endoplasmic reticulum lumen] (Rattus norvegicus)

ccn1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Ccn [endoplasmic reticulum lumen] (Drosophila melanogaster)

Cross References

ENSEMBL

ENST00000451137, ENSP00000398736, ENSG00000142871

OpenTargets

ENSG00000142871

GeneCards

CCN1

HPA

ENSG00000142871-CCN1

PRO

O00622

Pharos - Targets

O00622

GlyGen

O00622

PDB

4D11, 4D0Z

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60906 SMPD2	1	SMPD2 [plasma membrane] (R-HSA-194337)	0.556	3
UniProt:P05090 APOD	1	APOD [extracellular region] (R-HSA-5216199)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.527	10