Reactome | UBE2S [cytosol]

UBE2S [cytosol]

Stable Identifier

R-HSA-947622

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin-conjugating enzyme E2 S, UBE2S_HUMAN

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
        
        Binding of the MCC complex to the APC/C complex (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        Association of Securin with Cdc20:APC/C complex (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        Degradation of multiubiquitinated Securin (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Homo sapiens)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
        
        Association of cell cycle proteins with the APC/C:Cdh1 complex (Homo sapiens)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        Degradation of multiubiquitinated cell cycle proteins (Homo sapiens)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Homo sapiens)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of Cyclin B (Homo sapiens)
        
        Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        Degradation of multiubiquitinated Cyclin B (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Homo sapiens)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Homo sapiens)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Homo sapiens)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of Securin (Homo sapiens)
        
        Association of Securin with Cdc20:APC/C complex (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        Degradation of multiubiquitinated Securin (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Homo sapiens)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Homo sapiens)
        
        APC-Cdc20 mediated degradation of Nek2A (Homo sapiens)
        
        Association of Nek2A with MCC:APC/C (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        Degradation of multiubiquitinated Nek2A (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        Multiubiquitinated Nek2A [cytosol] (Homo sapiens)
        
        Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        Multiubiquitination of Nek2A (Homo sapiens)
        
        Multiubiquitinated Nek2A [cytosol] (Homo sapiens)
        
        Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Homo sapiens)
        
        Association of Cyclin A with the APC/C (Homo sapiens)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        Degradation multiubiquitinated Cyclin A (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Homo sapiens)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Homo sapiens)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Homo sapiens)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
      - Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Homo sapiens)
        
        Association of Cdh1 with the APC/C (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        Dissociation of Cdc20 from APC/C complex (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
      - Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
        
        Binding of the MCC complex to the APC/C complex (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Synthesis of DNA (Homo sapiens)
      - Switching of origins to a post-replicative state (Homo sapiens)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
        
        Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        UBE2S [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16763 UBE2S

Gene Names

UBE2S, E2EPF, OK/SW-cl.73

Chain

chain:1-222

Reference Genes

BioGPS Gene:27338 UBE2S

COSMIC (genes):UBE2S UBE2S

CTD Gene:27338 UBE2S

dbSNP Gene:27338 UBE2S

ENSEMBL:ENSG00000108106 UBE2S

HGNC:17895 UBE2S

KEGG:hsa:27338 UBE2S

Monarch:27338 UBE2S

NCBI Gene:27338 UBE2S

OMIM:610309 UBE2S

UCSC:Q16763 UBE2S

Reference Transcript

RefSeq:NM_014501.2 UBE2S

Other Identifiers

11719849_s_at

16875763

202779_PM_s_at

202779_s_at

27338

3713481

3713482

3713483

3713484

3747002

3747003

3747004

3747005

3747006

3871444

3871446

3871447

3871450

3871451

3871452

3871453

3871455

3871456

40619_at

8012958

8039491

893_at

894_g_at

A_32_P184933

GE58141

GO:0000209

GO:0003824

GO:0004842

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005680

GO:0005829

GO:0006511

GO:0010458

GO:0010994

GO:0010997

GO:0016567

GO:0016740

GO:0019787

GO:0030163

GO:0031145

GO:0032446

GO:0035519

GO:0036211

GO:0043161

GO:0043226

GO:0044314

GO:0051301

GO:0051603

GO:0061631

GO:0065003

GO:0070534

GO:0070979

GO:0085020

GO:0140096

GO:1904668

HMNXSV003019095

ILMN_1808591

ILMN_2217289

M91670_at

PH_hs_0030491

TC17001166.hg

TC19001872.hg

g7657045_3p_x_at

p8460

Participates

as a member of

as a candidate of

E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)

as a component of

phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)

Other forms of this molecule

Ub-C95-UBE2S [cytosol]

Ub-C95-UBE2S [nucleoplasm]

UBE2S [nucleoplasm]

Inferred To

ube2s [cytosol] (Danio rerio)

ube2s [cytosol] (Dictyostelium discoideum)

Ghost homologue of UBE2S [cytosol] (Caenorhabditis elegans)

Ghost homologue of UBE2S [cytosol] (Xenopus tropicalis)

UBE2S [cytosol] (Bos taurus)

UBE2S [cytosol] (Canis familiaris)

UBE2S [cytosol] (Drosophila melanogaster)

UBE2S [cytosol] (Gallus gallus)

UBE2S [cytosol] (Sus scrofa)

Ube2s [cytosol] (Mus musculus)

Ube2s [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_055316.2

ENSEMBL

ENST00000264552, ENSP00000264552

OpenTargets

ENSG00000108106

HPA

ENSG00000108106-UBE2S

PRO

Q16763

Pharos - Targets

Q16763

HMDB Protein

HMDBP09277

PDB

6S96, 5L9T, 7AHF, 6S98, 6QH3, 6QHK, 8TAU, 5BNB, 1ZDN

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	3

Cite Us!