Reactome | VCL [specific granule lumen]

VCL [specific granule lumen]

Stable Identifier

R-HSA-6799711

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

specific granule lumen

Synonyms

Vinculin

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P18206 VCL

Gene Names

VCL

Chain

chain:1-1134

Reference Genes

BioGPS Gene:7414 VCL

COSMIC (genes):VCL VCL

CTD Gene:7414 VCL

dbSNP Gene:7414 VCL

ENSEMBL:ENSG00000035403 VCL

HGNC:12665 VCL

KEGG:hsa:7414 VCL

Monarch:7414 VCL

NCBI Gene:7414 VCL

OMIM:193065 VCL

UCSC:P18206 VCL

Reference Transcript

Participates

as a member of

Specific granule lumen proteins [specific granule lumen] (Homo sapiens)

Other forms of this molecule

VCL [cytosol]

VCL [ficolin-1-rich granule lumen]

VCL [extracellular region]

VCL [secretory granule lumen]

VCL(95 kDa) [cytosol]

VCL(1-811)-ALK(1058-1620) fusion [cytosol]

VCL(1-811)-p-7Y-ALK(1058-1620) fusion [cytosol]

Inferred To

VCL [specific granule lumen] (Bos taurus)

VCL [specific granule lumen] (Canis familiaris)

VCL [specific granule lumen] (Gallus gallus)

VCL [specific granule lumen] (Sus scrofa)

vcla [specific granule lumen] (Danio rerio)

Vcl [specific granule lumen] (Mus musculus)

Vcl [specific granule lumen] (Rattus norvegicus)

Vinc [specific granule lumen] (Drosophila melanogaster)

deb-1 [specific granule lumen] (Caenorhabditis elegans)

fip-2 [specific granule lumen] (Dictyostelium discoideum)

Cross References

RefSeq

NP_054706.1, NP_003364.1

OpenTargets

ENSG00000035403

ENSEMBL

ENSG00000035403, ENSP00000361841, ENST00000372755, ENSP00000211998, ENST00000211998

HPA

ENSG00000035403-VCL

GeneCards

VCL

PRO

P18206

Pharos - Targets

P18206

Orphanet

VCL

GlyGen

P18206

PDB

4EHP, 5L0D, 5L0C, 5L0J, 5L0I, 5L0H, 5O2Q, 5L0G, 5L0F, 2IBF, 1RKE, 1RKC, 6UPW, 4DJ9, 4LN2, 3JBK, 3H2V, 3H2U, 3S90, 1TR2, 3RF3, 1SYQ, 7KTV, 3TJ6, 6FUY, 2GWW, 2HSQ, 3TJ5, 4LNP, 7KTU, 7KTW, 1YDI, 7KTT, 3VF0, 4PR9, 3MYI

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18010 IPAA			0.758	7
UniProt:Q6XVZ2 Q6XVZ2			0.719	4
UniProt:B0BXR4 B0BXR4			0.65	6
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	9
UniProt:Q62417-2 SORBS1			0.591	3
UniProt:Q969V4 TEKT1			0.556	3
UniProt:Q15654 TRIP6			0.553	2
UniProt:Q9NYB9 ABI2	2	ABI2 [cytosol] (R-HSA-1671647) p-4S-ABI2 [cytosol] (R-HSA-2029003)	0.553	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q9Y490 TLN1	4	TLN1 [extracellular region] (R-HSA-350693) TLN1(434-2541) [cytosol] (R-HSA-9855156) TLN1(1-433) [cytosol] (R-HSA-9855031) TLN1 [cytosol] (R-HSA-350713)	0.527	2
UniProt:P62979 RPS27A	20	RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-939208) RPS27A(77-156) [nucleoplasm] (R-HSA-6798734) Ub-33-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783024) Ub-63-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783200) Ub-6-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783040) Ub-11-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783085) Ub-48-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783075) Ub-29-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783146) Ub-63-RPS27A(1-76) [cytosol] (R-HSA-939248) RPS27A(1-76) [lysosomal lumen] (R-HSA-9660001) RPS27A(1-76) [cytosol] (R-HSA-939205) p-S65-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-9834951) Ub-48-RPS27A(1-76) [cytosol] (R-HSA-939202) RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-9834993) RPS27A(1-76) [late endosome lumen] (R-HSA-9660022) Ub-6-RPS27A(1-76) [nucleoplasm] (R-HSA-6782608) Ub-63-RPS27A(1-76) [nucleoplasm] (R-HSA-6782503) Ub-48-RPS27A(1-76) [nucleoplasm] (R-HSA-5683037) RPS27A(1-76) [nucleoplasm] (R-HSA-939849) Ub-63-RPS27A(1-76) [plasma membrane] (R-HSA-939855)	0.527	2
UniProt:P35221 CTNNA1	2	CTNNA1 [plasma membrane] (R-HSA-191735) CTNNA1 [cytosol] (R-HSA-191697)	0.527	2
UniProt:Q7Z4L5 TTC21B	2	TTC21B [ciliary tip] (R-HSA-5625349) TTC21B [cilium] (R-HSA-5610430)	0.508	2