Reactome | CLTA [lysosomal membrane]

CLTA [lysosomal membrane]

Stable Identifier

R-HSA-2980595

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal membrane

Synonyms

Clathrin light chain A, CLCA_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Gap junction trafficking and regulation (Homo sapiens)
    - Gap junction trafficking (Homo sapiens)
      - Gap junction degradation (Homo sapiens)
        
        Internalization of gap junction plaques (Homo sapiens)
        
        Invaginating gap junction plaques [lysosomal membrane] (Homo sapiens)
        
        planar gap junction plaques containing Dab2 [lysosomal membrane] (Homo sapiens)
        
        junctional plaque prior to invagination [lysosomal membrane] (Homo sapiens)
        
        Clathrin [lysosomal membrane] (Homo sapiens)
        
        Clathrin light chain [lysosomal membrane] (Homo sapiens)
        
        CLTA [lysosomal membrane] (Homo sapiens)
        
        Lysosomal degradation of gap junction plaques (Homo sapiens)
        
        Invaginating gap junction plaques [lysosomal membrane] (Homo sapiens)
        
        planar gap junction plaques containing Dab2 [lysosomal membrane] (Homo sapiens)
        
        junctional plaque prior to invagination [lysosomal membrane] (Homo sapiens)
        
        Clathrin [lysosomal membrane] (Homo sapiens)
        
        Clathrin light chain [lysosomal membrane] (Homo sapiens)
        
        CLTA [lysosomal membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P09496 CLTA

Gene Names

CLTA

Chain

chain:1-248

Reference Genes

BioGPS Gene:1211 CLTA

COSMIC - genes:CLTA CLTA

CTD Gene:1211 CLTA

dbSNP Gene:1211 CLTA

ENSEMBL:ENSG00000122705 CLTA

HGNC:2090 CLTA

KEGG:hsa:1211 CLTA

Monarch:1211 CLTA

NCBI Gene:1211 CLTA

OMIM:118960 CLTA

UCSC:P09496 CLTA

Reference Transcript

Participates

as a candidate of

Clathrin light chain [lysosomal membrane] (Homo sapiens)

Other forms of this molecule

CLTA [plasma membrane]

CLTA [clathrin-coated endocytic vesicle membrane]

CLTA [endolysosome membrane]

CLTA [cytosol]

CLTA [trans-Golgi network membrane]

Inferred To

CLTA [lysosomal membrane] (Bos taurus)

CLTA [lysosomal membrane] (Canis familiaris)

CLTA [lysosomal membrane] (Gallus gallus)

CLTA [lysosomal membrane] (Sus scrofa)

clic-1 [lysosomal membrane] (Caenorhabditis elegans)

Clta [lysosomal membrane] (Mus musculus)

Clta [lysosomal membrane] (Rattus norvegicus)

Clc [lysosomal membrane] (Drosophila melanogaster)

CLC1 [lysosomal membrane] (Saccharomyces cerevisiae)

clc1 [lysosomal membrane] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001070145.1, NP_001171689.1, NP_001171691.1, NP_009027.1, NP_001824.1

OpenTargets

ENSG00000122705

ENSEMBL

ENSP00000437508, ENSP00000379848, ENSP00000419746, ENST00000345519, ENSP00000242284, ENSP00000242285, ENST00000470744, ENSG00000122705, ENST00000242285, ENST00000540080, ENST00000396603

HPA

ENSG00000122705-CLTA

GeneCards

CLTA

PRO

P09496

Pharos - Targets

P09496

GlyGen

P09496

PDB

6E5N

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.527	2
UniProt:Q9Y6A5 TACC3	1	TACC3 [cytosol] (R-HSA-2160956)	0.499	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	4

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