Reactome | RPRD1B [nucleoplasm]

RPRD1B [nucleoplasm]

Stable Identifier

R-HSA-6814894

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Regulation of nuclear pre-mRNA domain-containing protein 1B, RPR1B_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1B [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1B [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1B [nucleoplasm] (Homo sapiens)
      - RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1B [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1B [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1B [nucleoplasm] (Homo sapiens)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1B [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1B [nucleoplasm] (Homo sapiens)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1B [nucleoplasm] (Homo sapiens)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RPRD1A,B:RPRD2:RPAP2 [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1B [nucleoplasm] (Homo sapiens)
    - RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Homo sapiens)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RPRD1A,B:RPRD2:RPAP2 [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1B [nucleoplasm] (Homo sapiens)
      - RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NQG5 RPRD1B

Gene Names

RPRD1B, C20orf77, CREPT

Chain

initiator methionine:, chain:2-326

Reference Genes

BioGPS Gene:58490 RPRD1B

COSMIC (genes):RPRD1B RPRD1B

CTD Gene:58490 RPRD1B

dbSNP Gene:58490 RPRD1B

ENSEMBL:ENSG00000101413 RPRD1B

HGNC:16209 RPRD1B

KEGG:hsa:58490 RPRD1B

Monarch:58490 RPRD1B

NCBI Gene:58490 RPRD1B

OMIM:614694 RPRD1B

UCSC:Q9NQG5 RPRD1B

Reference Transcript

RefSeq:NM_021215.3 RPRD1B

Other Identifiers

11718279_at

11747127_a_at

16913493

225024_PM_at

225024_at

3884452

3884453

3884454

3884455

3884456

3884457

3884459

3884460

3884464

3884465

3884467

3884468

3884469

3884471

3884475

3884476

3884478

3884479

3884480

3884483

3884484

3884485

3884488

51150_at

58490

8062433

88772_at

A_14_P123728

A_14_P139876

A_23_P91207

A_24_P250499

GE56491

GO:0000993

GO:0001111

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0006355

GO:0006357

GO:0008284

GO:0008420

GO:0010564

GO:0016071

GO:0016787

GO:0031124

GO:0042802

GO:0043226

GO:0045944

GO:0097550

GO:0099122

GO:0140096

HMNXSV003014181

HMNXSV003046390

Hs.27192.1.S2_3p_at

Hs.27192.1.S2_3p_x_at

ILMN_1765400

PH_hs_0023405

TC20000278.hg

Participates

as a member of

RPRD1A,B [nucleoplasm] (Homo sapiens)

Inferred To

RTT103 [nucleoplasm] (Saccharomyces cerevisiae)

cids-1 [nucleoplasm] (Caenorhabditis elegans)

Dmel\CG9018 [nucleoplasm] (Drosophila melanogaster)

RPRD1B [nucleoplasm] (Bos taurus)

RPRD1B [nucleoplasm] (Canis familiaris)

RPRD1B [nucleoplasm] (Schizosaccharomyces pombe)

RPRD1B [nucleoplasm] (Sus scrofa)

Rprd1b [nucleoplasm] (Mus musculus)

Rprd1b [nucleoplasm] (Rattus norvegicus)

CREPT [nucleoplasm] (Gallus gallus)

rprd1b [nucleoplasm] (Xenopus tropicalis)

Cross References

ENSEMBL

ENSG00000101413, ENST00000373433, ENSP00000362532

OpenTargets

ENSG00000101413

GeneCards

RPRD1B

HPA

ENSG00000101413-RPRD1B

PRO

Q9NQG5

Pharos - Targets

Q9NQG5

GlyGen

Q9NQG5

PDB

4HFG, 4Q94, 4Q96, 4FLA, 4NAD, 9B9L, 4FU3

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IXW5 RPAP2	1	RPAP2 [nucleoplasm] (R-HSA-6810227)	0.757	6
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.643	3
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [secretory granule lumen] (R-HSA-6803287)	0.556	3
UniProt:Q9H5V9 STEEP1	1	STEEP1 [nucleoplasm] (R-HSA-9769596)	0.556	3
UniProt:P09017 HOXC4	1	HOXC4 [nucleoplasm] (R-HSA-5617871)	0.556	3
UniProt:Q7KZ85 SUPT6H	1	SUPT6H [nucleoplasm] (R-HSA-8932908)	0.527	3
UniProt:P62875 POLR2L	2	POLR2L [cytosol] (R-HSA-1964467) POLR2L [nucleoplasm] (R-HSA-83715)	0.527	3
UniProt:O96019 ACTL6A	1	ACTL6A [nucleoplasm] (R-HSA-2980912)	0.527	2
UniProt:P02675 FGB	5	FGB [extracellular region] (R-HSA-140584) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [plasma membrane] (R-HSA-140917) FGB(31-491) [extracellular region] (R-HSA-140846) FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921)	0.527	2
UniProt:P61218 POLR2F	2	POLR2F [cytosol] (R-HSA-1964441) POLR2F [nucleoplasm] (R-HSA-83714)	0.527	4
UniProt:Q5VT52 RPRD2	1	RPRD2 [nucleoplasm] (R-HSA-6814906)	0.527	3
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	2
UniProt:O00267 SUPT5H	1	p-SUPT5H [nucleoplasm] (R-HSA-3009372)	0.527	2
UniProt:Q9Y3F4 STRAP	1	STRAP [cytosol] (R-HSA-2127556)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7