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TRIM28 [nucleoplasm]
Stable Identifier
R-HSA-974998
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Transcription intermediary factor 1-beta, TIF1B_HUMAN, KAP1
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Early Events (Homo sapiens)
Latent Transcriptinally Repressed HCMV Genome (Homo sapiens)
TRIM28 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
KRAB-ZNF / KAP Interaction (Homo sapiens)
KAP (KRAB-Domain Associated Protein) [nucleoplasm] (Homo sapiens)
TRIM28 [nucleoplasm] (Homo sapiens)
KRAB-ZNF / KAP Complex [nucleoplasm] (Homo sapiens)
KAP (KRAB-Domain Associated Protein) [nucleoplasm] (Homo sapiens)
TRIM28 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Homo sapiens)
TRIM28 [nucleoplasm] (Homo sapiens)
TRIM28:ZNF350 [nucleoplasm] (Homo sapiens)
TRIM28 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13263 TRIM28
Gene Names
TRIM28, KAP1, RNF96, TIF1B
Chain
initiator methionine:1, chain:2-835
Reference Genes
BioGPS Gene:10155 TRIM28
COSMIC (genes):TRIM28 TRIM28
CTD Gene:10155 TRIM28
dbSNP Gene:10155 TRIM28
ENSEMBL:ENSG00000130726 TRIM28
ENSEMBL:ENSG00000130726.12 TRIM28
HGNC:16384 TRIM28
KEGG Gene (Homo sapiens):10155 TRIM28
Monarch:10155 TRIM28
NCBI Gene:10155 TRIM28
OMIM:601742 TRIM28
UCSC:Q13263 TRIM28
Reference Transcript
RefSeq:NM_005762.2 TRIM28
Other Identifiers
10155
11715373_a_at
16866337
200990_PM_at
200990_at
33425_at
3844240
3844241
3844242
3844243
3844244
3844245
3844249
3844250
3844253
3844254
3844255
3844256
3844257
3844258
3844259
3844261
3844262
3844263
3844264
3844266
3844268
3844269
3844271
3844272
3844273
3844274
3844275
8031913
A_14_P116219
A_23_P89884
GE61192
GO:0000122
GO:0000785
GO:0000791
GO:0000792
GO:0001701
GO:0001837
GO:0002376
GO:0003677
GO:0003682
GO:0003713
GO:0003714
GO:0003723
GO:0003824
GO:0004672
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006281
GO:0006325
GO:0006351
GO:0006355
GO:0006468
GO:0006886
GO:0006913
GO:0007566
GO:0008270
GO:0016740
GO:0016925
GO:0019789
GO:0022414
GO:0030154
GO:0031625
GO:0032092
GO:0032991
GO:0035851
GO:0036211
GO:0042307
GO:0043045
GO:0043226
GO:0043388
GO:0044790
GO:0045087
GO:0045739
GO:0045869
GO:0045892
GO:0045893
GO:0046777
GO:0046872
GO:0048856
GO:0060028
GO:0060669
GO:0061630
GO:0070087
GO:0090309
GO:0090575
GO:0098542
GO:0140096
GO:0140110
GO:1901536
GO:1990841
GO:2000653
HMNXSV003008569
ILMN_1736575
PH_hs_0025287
TC19000971.hg
U95040_at
g5032178_3p_at
g5032178_3p_x_at
Participates
as a component of
TRIM28:ZNF350 [nucleoplasm] (Homo sapiens)
as a member of
KAP (KRAB-Domain Associated Protein) [nucleoplasm] (Homo sapiens)
This entity regulates
Negatively
Latent Transcriptinally Repressed HCMV Genome
(Homo sapiens)
Other forms of this molecule
SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm]
Inferred To
bon [nucleoplasm]
(Drosophila melanogaster)
TRIM28 [nucleoplasm]
(Bos taurus)
TRIM28 [nucleoplasm]
(Dictyostelium discoideum)
TRIM28 [nucleoplasm]
(Gallus gallus)
TRIM28 [nucleoplasm]
(Mus musculus)
TRIM28 [nucleoplasm]
(Rattus norvegicus)
TRIM28 [nucleoplasm]
(Sus scrofa)
trim28 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_005753.1
Guide to Pharmacology - Targets
2253
OpenTargets
ENSG00000130726
GeneCards
Q13263
HPA
ENSG00000130726-TRIM28
Ensembl
ENSG00000130726
,
ENSP00000253024
,
ENST00000341753
,
ENST00000253024
,
ENSP00000342232
PRO
Q13263
Pharos - Targets
Q13263
Orphanet
27308
PDB
6I9H
,
1FP0
,
2RO1
,
2YVR
,
6QAJ
,
7Z36
,
6H3A
,
6QU1
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.869
11
UniProt:Q9UBF1 MAGC2
0.792
14
UniProt:Q13185 CBX3
1
CBX3 [nucleoplasm]
(R-HSA-427386)
0.752
4
UniProt:P43356 MAGA2
0.668
6
UniProt:P43357 MAGA3
0.646
3
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.643
3
UniProt:Q12873 CHD3
2
CHD3 [nucleoplasm]
(R-HSA-4657012)
monoSUMO1-K1971-CHD3 [nucleoplasm]
(R-HSA-8956372)
0.573
4
UniProt:Q9BQF6 SENP7
0.564
3
UniProt:P83917 CBX1
0.564
2
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.564
2
UniProt:O75376 NCOR1
2
NCOR1 [cytosol]
(R-HSA-1253310)
NCOR1 [nucleoplasm]
(R-HSA-442501)
0.556
4
IntAct:EBI-16203811 H3(1027)
0.544
2
UniProt:Q99608 NDN
1
NDN [nucleoplasm]
(R-HSA-6789966)
0.536
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q77M19 Q77M19
0.527
3
UniProt:Q14684 RRP1B
0.527
2
UniProt:Q5T7N2 LITD1
0.527
4
UniProt:Q9HCI5 MAGE1
0.524
2
UniProt:P23198 Cbx3
1
Cbx3 [nucleoplasm]
(R-MMU-573362)
0.524
2
UniProt:P43360 MAGA6
0.524
2
UniProt:Q14684-1 RRP1B
0.512
4
IntAct:EBI-2695616 ERE
0.499
2
UniProt:Q8TF47-3 ZFP90
0.499
2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.462
2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
UniProt:O15164 TRIM24
4
TRIM24(1-626)-FGFR1(429-822) fusion [cytosol]
(R-HSA-1614442)
TRIM24(1-626)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1839012)
TRIM24(1-510)-BRAF(381-766) fusion [cytosol]
(R-HSA-6802477)
TRIM24(1-510)-p-BRAF(381-766) fusion [cytosol]
(R-HSA-6802555)
0.462
2
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