Reactome | IPO7 [nuclear envelope]

IPO7 [nuclear envelope]

Stable Identifier

R-HSA-5216002

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nuclear envelope

Synonyms

Importin-7, IPO7_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Dengue Virus Infection (Homo sapiens)
      - Dengue Virus Genome Translation and Replication (Homo sapiens)
        
        Maturation of DENV proteins (Homo sapiens)
        
        C dimer localizes to nucleus (Homo sapiens)
        
        IPO7 [nuclear envelope] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95373 IPO7

Gene Names

IPO7, RANBP7

Chain

chain:1-1038

Reference Genes

BioGPS Gene:10527 IPO7

COSMIC - genes:IPO7 IPO7

CTD Gene:10527 IPO7

dbSNP Gene:10527 IPO7

ENSEMBL:ENSG00000205339 IPO7

HGNC:9852 IPO7

KEGG:hsa:10527 IPO7

Monarch:10527 IPO7

NCBI Gene:10527 IPO7

OMIM:605586 IPO7

UCSC:O95373 IPO7

Reference Transcript

RefSeq:NM_006391.3 IPO7

Other Identifiers

10527

11725670_s_at

11725671_a_at

11725672_s_at

11757753_s_at

16721773

200992_PM_at

200992_at

200993_PM_at

200993_at

200994_PM_at

200994_at

200995_PM_at

200995_at

2454242

2454250

2454252

2454254

2454264

2454272

2454276

3319841

3319842

3319843

3319847

3319849

3319850

3319853

3319854

3319855

3319856

3319857

3319858

3319859

3319860

3319861

3319863

3319865

3319866

3319868

3319870

3319871

3319872

3319873

3319874

3319875

3319876

3319878

3319879

3319880

3319881

3319882

3319884

3319886

3319887

3319888

3319889

3319890

3319891

3319892

3505681

3505683

3505687

3505695

3505697

3505699

3505701

35255_at

4008541

4008543

47570_at

7938313

88491_at

A_14_P105627

A_23_P331598

GE79576

GO:0002376

GO:0005515

GO:0005634

GO:0005635

GO:0005643

GO:0005654

GO:0005737

GO:0005829

GO:0006606

GO:0006886

GO:0006913

GO:0015031

GO:0016020

GO:0030695

GO:0031267

GO:0042393

GO:0045087

GO:0045668

GO:0045786

GO:0046332

GO:0098542

GO:1900182

GO:1901331

HMNXSV003056136

Hs.5151.0.S2_3p_at

Hs.5151.0.S3_3p_at

Hs.5151.0.S4_3p_at

Hs.5151.0.S4_3p_x_at

Hs.5151.0.S5_3p_at

ILMN_1652378

PH_hs_0035976

TC11000170.hg

TC11000171.hg

This entity regulates

Positively

C dimer localizes to nucleus (Homo sapiens)

Cross References

RefSeq

NP_006382.1

ENSEMBL

ENST00000379719, ENSG00000205339, ENSP00000369042

OpenTargets

ENSG00000205339

GeneCards

IPO7

HPA

ENSG00000205339-IPO7

PRO

O95373

Pharos - Targets

O95373

GlyGen

O95373

HMDB Protein

HMDBP08467

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9ULW2 FZD10	1	FZD10 [plasma membrane] (R-HSA-443943)	0.643	3
UniProt:Q5SSJ5 HP1B3			0.643	4
UniProt:P28335 HTR2C	1	HTR2C [plasma membrane] (R-HSA-390965)	0.643	3
UniProt:Q8N7X8 SIGL1			0.643	4
UniProt:P31260 HXA10			0.641	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.615	13
UniProt:Q9NWT8 AURKAIP1	1	AURKAIP1 [mitochondrial inner membrane] (R-HSA-5368203)	0.527	3
UniProt:Q9NZQ7 CD274	15	p-S184,T180-CD274 [endoplasmic reticulum membrane] (R-HSA-9929349) p-S184,T180-CD274 [cytosol] (R-HSA-9936160) CD274 [endoplasmic reticulum membrane] (R-HSA-9930703) N-glycosylated CD274 [endoplasmic reticulum membrane] (R-HSA-9931256) p-T194,T210-CD274 [endoplasmic reticulum membrane] (R-HSA-9931399) p-S195-CD274 [endoplasmic reticulum membrane] (R-HSA-9931301) p-S195-CD274 [cytosol] (R-HSA-9931259) CD274 [cytosol] (R-HSA-9925063) p-T285,T290-CD274 [endoplasmic reticulum membrane] (R-HSA-9931388) p-Y112-CD274 [endoplasmic reticulum membrane] (R-HSA-9931296) polyLacNac-Glycosylated CD274 [Golgi membrane] (R-HSA-9931289) K63polyUb-polyLacNac-Glycosylated CD274 [Golgi membrane] (R-HSA-9931435) N-glycosylated CD274 [Golgi membrane] (R-HSA-9931315) CD274 [plasma membrane] (R-HSA-3211776) K63polyUb-polyLacNac-Glycosylated CD274 [plasma membrane] (R-HSA-9931307)	0.527	2
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.527	3
UniProt:Q9H813 PACC1			0.527	2
UniProt:Q8NAP3 ZBT38			0.527	2
UniProt:Q9UEU0 VTI1B	2	VTI1B [platelet alpha granule lumen] (R-HSA-8862964) VTI1B [extracellular region] (R-HSA-8862983)	0.527	2
UniProt:Q86VU5 CMTD1			0.527	4
UniProt:P21453 S1PR1	1	S1PR1 [plasma membrane] (R-HSA-419340)	0.527	2
UniProt:P43115 PTGER3	1	PTGER3 [plasma membrane] (R-HSA-391828)	0.527	2
UniProt:Q8IZT6 ASPM			0.527	2
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [specific granule lumen] (R-HSA-6799646)	0.527	3
UniProt:Q7L2R6 ZNF765	1	ZNF765 [nucleoplasm] (R-HSA-9843524)	0.499	2
UniProt:Q9BSK1 ZNF577	1	ZNF577 [nucleoplasm] (R-HSA-2127587)	0.499	2
UniProt:P01116-2 KRAS	8	S-Farn-Me KRAS4B [plasma membrane] (R-HSA-9647815) S-Farn-Me KRAS4B [endoplasmic reticulum membrane] (R-HSA-9649690) S-Farn KRAS4B [endoplasmic reticulum membrane] (R-HSA-9649698) S-Farn proKRAS4B [endoplasmic reticulum membrane] (R-HSA-9649693) pro-KRAS4B [cytosol] (R-HSA-9649686) pS181-S-Farn-Me KRAS4B [plasma membrane] (R-HSA-9653482) S-Farn-Me KRAS4B [cytosol] (R-HSA-9654510) pS181-S-Farn-Me KRAS4B [mitochondrial outer membrane] (R-HSA-9653578)	0.499	5
UniProt:P01116-1 KRAS	7	S-Farn-Me-PalmS KRAS4A [plasma membrane] (R-HSA-9647915) S-Farn KRAS4A [endoplasmic reticulum membrane] (R-HSA-9649702) S-Farn-Me KRAS4A [endoplasmic reticulum membrane] (R-HSA-9647806) S-Farn proKRAS4A [endoplasmic reticulum membrane] (R-HSA-9649695) pro-KRAS4A [cytosol] (R-HSA-9649683) S-Farn-Me PalmS KRAS4A [Golgi membrane] (R-HSA-9647903) S-Farn-Me KRAS4A [plasma membrane] (R-HSA-9647811)	0.499	3

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