Reactome | p-S19-MYL12A [cytosol]

p-S19-MYL12A [cytosol]

Stable Identifier

R-HSA-390749

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S19-MRLC3, Phosphorylated Myosin regulatory light chain MRLC3

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P19105 MYL12A

Gene Names

MYL12A, MLCB, MRLC3, RLC

Chain

chain:1-171

Reference Genes

BioGPS Gene:10627 MYL12A

COSMIC (genes):MYL12A MYL12A

CTD Gene:10627 MYL12A

dbSNP Gene:10627 MYL12A

ENSEMBL:ENSG00000101608 MYL12A

ENSEMBL_homo_sapiens_GENE:ENSG00000101608.13 MYL12A

HGNC:16701 MYL12A

KEGG Gene (Homo sapiens):10627 MYL12A

Monarch:10627 MYL12A

NCBI Gene:10627 MYL12A

OMIM:609211 MYL12A

UCSC:P19105 MYL12A

Reference Transcript

Other Identifiers

10627

11743976_at

11743977_s_at

11743978_x_at

16850609

201318_PM_s_at

201318_s_at

33447_at

3776428

3776429

3776431

3776436

3776439

3776441

3776443

3776444

3776445

3776446

3776447

3776454

3776460

8019924

A_23_P4572

GE62910

GO:0001725

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005856

GO:0007155

GO:0008360

GO:0016459

GO:0016460

GO:0030018

GO:0032991

GO:0035254

GO:0042060

GO:0043226

GO:0046872

GO:0048856

GO:0070062

GO:0070527

GO:0072659

HMNXSV003021878

ILMN_1675848

PH_hs_0012781

PH_hs_0035711

TC18000016.hg

X54304_at

Participates

as a member of

Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)

as an output of

PAKs phosphorylate MLC (Homo sapiens)

Other forms of this molecule

MYL12A [cytosol]

Inferred To

phospho-p-S19-MYL12A [cytosol] (Bos taurus)

phospho-p-S19-MYL12A [cytosol] (Caenorhabditis elegans)

phospho-p-S19-MYL12A [cytosol] (Drosophila melanogaster)

phospho-p-S19-MYL12A [cytosol] (Gallus gallus)

phospho-p-S19-MYL12A [cytosol] (Plasmodium falciparum)

phospho-p-S19-MYL12A [cytosol] (Rattus norvegicus)

phospho-p-S19-MYL12A [cytosol] (Saccharomyces cerevisiae)

phospho-p-S19-MYL12A [cytosol] (Schizosaccharomyces pombe)

Homologues of p-S19-MYL12A [cytosol] (Gallus gallus)

phospho-MYL12A [cytosol] (Canis familiaris)

phospho-MYL12A [cytosol] (Sus scrofa)

phospho-myl12b [cytosol] (Xenopus tropicalis)

phospho-myl12.2 [cytosol] (Danio rerio)

phospho-MYL12B [cytosol] (Gallus gallus)

phospho-mlcR [cytosol] (Dictyostelium discoideum)

Modified Residues

Name

O-phospho-L-serine at 19

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_006462.1, NP_001289977.1, NP_001289978.1, NP_001289976.1

OpenTargets

ENSG00000101608

HPA

ENSG00000101608-MYL12A

GeneCards

P19105

Ensembl

ENSP00000217652, ENSG00000101608, ENST00000217652, ENST00000578611, ENST00000579226, ENSP00000462171, ENSP00000463614, ENST00000536605, ENSP00000441231

PRO

P19105

Pharos - Targets

P19105

HMDB Protein

HMDBP02840

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	19
UniProt:Q14164 IKBKE	5	monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535) IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521)	0.589	2
UniProt:Q92614 MYO18A	4	MYO18A(1-1462)-FLT3(595-993) fusion [cytosol] (R-HSA-9703314) MYO18A(1-1462)-p-4Y-FLT3(595-993) fusion [cytosol] (R-HSA-9703306) MYO18A(1-1691)-FGFR1(429-822) fusion [cytosol] (R-HSA-1606446) MYO18A(1-1691)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839006)	0.527	2
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.527	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2

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