Reactome | WARS [cytosol]

WARS [cytosol]

Stable Identifier

R-HSA-379603

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tryptophanyl-tRNA synthetase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P23381 WARS1

Gene Names

WARS1, IFI53, WARS, WRS

Chain

initiator methionine:, chain:2-471, chain:71-471, chain:94-471

Reference Genes

BioGPS Gene:7453 WARS1

CTD Gene:7453 WARS1

dbSNP Gene:7453 WARS1

ENSEMBL:ENSG00000140105 WARS

ENSEMBL_homo_sapiens_GENE:ENSG00000140105.18 WARS1

HGNC:12729 WARS1

KEGG Gene (Homo sapiens):7453 WARS1

Monarch:7453 WARS1

NCBI Gene:7453 WARS1

OMIM:191050 WARS1

UCSC:P23381 WARS1

Reference Transcript

Other Identifiers

11726286_a_at

11726287_a_at

11747666_a_at

16796694

200628_PM_s_at

200628_s_at

200629_PM_at

200629_at

3579547

3579548

3579549

3579550

3579552

3579555

3579557

3579559

3579561

3579562

3579564

3579568

3579569

3579576

3579577

3579578

3579579

3579582

3579583

3579584

3579585

3579586

3579587

38121_at

7453

7981290

A_23_P65651

GE58326

GE86758

GO:0000166

GO:0001525

GO:0003824

GO:0004812

GO:0004830

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0006399

GO:0006412

GO:0006418

GO:0006436

GO:0006469

GO:0006520

GO:0008285

GO:0010628

GO:0016874

GO:0019210

GO:0019901

GO:0019904

GO:0031334

GO:0032991

GO:0036211

GO:0042803

GO:0043226

GO:0045765

GO:0048856

GO:0065003

GO:0070062

GO:0098772

GO:0140098

HMNXSV003002182

ILMN_1727271

ILMN_2337655

PH_hs_0027714

TC14001509.hg

X59892_at

g340367_3p_a_at

g7710155_3p_at

Participates

as a component of

WARS dimer [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_006720312.1, NP_004175.2, XP_005268101.1, NP_998811.1, XP_016877117.1, XP_011535435.1, XP_011535438.1, NP_998810.1, XP_011535437.1, XP_016877118.1, XP_016877116.1, NP_776049.1

OpenTargets

ENSG00000140105

GeneCards

P23381

HPA

ENSG00000140105-WARS1

Ensembl

ENSP00000339485, ENST00000358655, ENSG00000140105, ENSP00000451887, ENSP00000451460, ENST00000557135, ENST00000344102, ENSP00000347495, ENST00000556645, ENSP00000376620, ENST00000355338, ENST00000392882, ENSP00000351481

PRO

P23381

Pharos - Targets

P23381

Orphanet

25793

HMDB Protein

HMDBP00574

PDB

5UJI, 2QUJ, 1R6U, 2AZX, 5UJJ, 2DR2, 2QUK, 1ULH, 2AKE, 2QUH, 1O5T, 2QUI, 1R6T

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	5

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