Reactome | WARS [cytosol]

WARS [cytosol]

Stable Identifier

R-HSA-379603

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tryptophanyl-tRNA synthetase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P23381 WARS1

Gene Names

WARS1, IFI53, WARS, WRS

Chain

initiator methionine:1, chain:2-471, chain:71-471, chain:94-471

Reference Genes

BioGPS Gene:7453 WARS1

COSMIC (genes):WARS WARS1

CTD Gene:7453 WARS1

dbSNP Gene:7453 WARS1

ENSEMBL:ENSG00000140105 WARS1

HGNC:12729 WARS1

KEGG:hsa:7453 WARS1

Monarch:7453 WARS1

NCBI Entrez Gene:7453 WARS1

OMIM:191050 WARS1

UCSC:P23381 WARS1

Reference Transcript

Other Identifiers

11726286_a_at

11726287_a_at

11747666_a_at

11760994_at

16796694

200628_PM_s_at

200628_s_at

200629_PM_at

200629_at

3579547

3579548

3579549

3579550

3579551

3579552

3579553

3579554

3579555

3579557

3579559

3579560

3579561

3579562

3579563

3579564

3579566

3579567

3579568

3579569

3579571

3579575

3579576

3579577

3579578

3579579

3579580

3579581

3579582

3579583

3579584

3579585

3579586

3579587

38121_at

66555_at

7453

7981290

A_23_P65651

GE58326

GE607599

GE86758

GO:0000166

GO:0001525

GO:0003824

GO:0004812

GO:0004830

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0006399

GO:0006412

GO:0006418

GO:0006436

GO:0006469

GO:0006520

GO:0008285

GO:0010628

GO:0016874

GO:0019210

GO:0019901

GO:0019904

GO:0031334

GO:0032991

GO:0042803

GO:0045765

GO:0070062

GO:0098772

GO:0140098

HMNXSV003002182

ILMN_1727271

ILMN_2337655

PH_hs_0027714

TC14001509.hg

X59892_at

g340367_3p_a_at

g7710155_3p_at

Participates

as a component of

WARS dimer [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_016877116.1, XP_047287720.1, XP_054232680.1, NP_004175.2, XP_011535437.1, XP_011535435.1, XP_005268101.1, XP_011535438.1, XP_047287714.1, XP_047287718.1, XP_047287715.1, XP_016877118.1, XP_016877117.1, XP_047287716.1, NP_776049.1, XP_047287713.1, NP_998810.1, XP_047287719.1, XP_047287717.1, XP_006720312.1, XP_024305475.1, NP_998811.1, XP_054232676.1, XP_054232675.1, XP_054232671.1, XP_054232672.1, XP_054232673.1, XP_054232674.1, XP_054232679.1, XP_054232677.1, XP_054232678.1

OpenTargets

ENSG00000140105

ENSEMBL

ENST00000344102, ENST00000392882, ENSP00000351481, ENSP00000339485, ENSG00000140105, ENSP00000347495, ENST00000358655, ENSP00000376620, ENSP00000451887, ENST00000556645, ENST00000355338, ENST00000557135, ENSP00000451460

HPA

ENSG00000140105-WARS1

GeneCards

WARS1

PRO

P23381

Pharos - Targets

P23381

Orphanet

WARS1

GlyGen

P23381

PDB

5UJI, 1R6T, 1O5T, 2AZX, 2QUH, 2DR2, 2AKE, 2QUK, 2QUI, 2QUJ, 1ULH, 1R6U, 5UJJ

HMDB Protein

HMDBP00574

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	5

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