Reactome | TWF1 [cytosol]

TWF1 [cytosol]

Stable Identifier

R-HSA-9667687

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Twinfilin-1, TWF1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOBTB GTPase Cycle (Homo sapiens)
        
        RHOBTB2 GTPase cycle (Homo sapiens)
        
        RHOBTB2 binds interacting proteins at the endosome membrane (Homo sapiens)
        
        RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
        
        TWF1 [cytosol] (Homo sapiens)
        
        RHOBTB2:GTP:RHOBTB2 interacting proteins [endosome membrane] (Homo sapiens)
        
        RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
        
        TWF1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q12792 TWF1

Gene Names

TWF1, PTK9

Chain

initiator methionine:1, chain:2-350

Reference Genes

BioGPS Gene:5756 TWF1

COSMIC (genes):TWF1 TWF1

CTD Gene:5756 TWF1

dbSNP Gene:5756 TWF1

ENSEMBL:ENSG00000151239 TWF1

ENSEMBL:ENSG00000151239.14 TWF1

HGNC:9620 TWF1

KEGG Gene (Homo sapiens):5756 TWF1

Monarch:5756 TWF1

NCBI Gene:5756 TWF1

OMIM:610932 TWF1

UCSC:Q12792 TWF1

Reference Transcript

Other Identifiers

1064_at

11716945_s_at

11751302_a_at

11758185_s_at

16763390

201745_PM_at

201745_at

214007_PM_s_at

214007_s_at

3451709

3451710

3451711

3451713

3451714

3451715

3451716

3451717

3451719

3451724

3451727

3451730

3451731

3751447

3751449

3751450

3751451

3751452

3751453

3751454

3751455

3751456

4027784

4027785

4027786

5756

7962441

8013906

A_23_P48166

GE58856

GO:0003012

GO:0003779

GO:0003785

GO:0005515

GO:0005524

GO:0005546

GO:0005737

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005911

GO:0005925

GO:0007010

GO:0008092

GO:0008289

GO:0010591

GO:0010613

GO:0010976

GO:0015629

GO:0030016

GO:0030042

GO:0030154

GO:0030175

GO:0030837

GO:0032587

GO:0032956

GO:0036211

GO:0042989

GO:0043226

GO:0043538

GO:0044877

GO:0045296

GO:0048471

GO:0048856

GO:0051015

GO:0051016

GO:0065003

HMNXSV003057795

Hs.82643.1.S1_3p_a_at

ILMN_1681203

ILMN_1682675

PH_hs_0029392

TC12001413.hg

U02680_at

g4506274_3p_at

Participates

as a candidate of

RHOBTB2 interacting proteins [cytosol] (Homo sapiens)

as a component of

Stereocilium shaft [cytosol] (Homo sapiens)

Inferred To

twf [cytosol] (Drosophila melanogaster)

TWF1 [cytosol] (Bos taurus)

TWF1 [cytosol] (Gallus gallus)

TWF1 [cytosol] (Saccharomyces cerevisiae)

twf1 [cytosol] (Schizosaccharomyces pombe)

twf1 [cytosol] (Xenopus tropicalis)

zgc:92472 [cytosol] (Danio rerio)

Twf1 [cytosol] (Mus musculus)

Twf1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001229326.1, NP_002813.3

Guide to Pharmacology - Targets

2266

OpenTargets

ENSG00000151239

GeneCards

Q12792

HPA

ENSG00000151239-TWF1

Ensembl

ENST00000552521, ENST00000548315, ENST00000395510, ENSP00000448750, ENSG00000151239, ENSP00000378886, ENSP00000449428

PRO

Q12792

Pharos - Targets

Q12792

PDB

7CCC

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	3