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TWF1 [cytosol]
Stable Identifier
R-HSA-9667687
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Twinfilin-1, TWF1_HUMAN
Locations in the PathwayBrowser
Expand all
Sensory Perception (Homo sapiens)
Sensory processing of sound (Homo sapiens)
Sensory processing of sound by inner hair cells of the cochlea (Homo sapiens)
Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell (Homo sapiens)
MET channel:Tip link:USH1C:USH1G:MYO7A:cytoskeleton (IHC) [plasma membrane] (Homo sapiens)
Inner hair cell stereocilium cytoskeleton [cytosol] (Homo sapiens)
Stereocilium shaft [cytosol] (Homo sapiens)
TWF1 [cytosol] (Homo sapiens)
Sensory processing of sound by outer hair cells of the cochlea (Homo sapiens)
Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell (Homo sapiens)
MET channel:Tip link:USH1C:USH1G:MYO7A:cytoskeleton (OHC) [plasma membrane] (Homo sapiens)
Outer hair cell stereocilium cytoskeleton [cytosol] (Homo sapiens)
Stereocilium shaft [cytosol] (Homo sapiens)
TWF1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOBTB GTPase Cycle (Homo sapiens)
RHOBTB2 GTPase cycle (Homo sapiens)
RHOBTB2 binds interacting proteins at the endosome membrane (Homo sapiens)
RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
TWF1 [cytosol] (Homo sapiens)
RHOBTB2:GTP:RHOBTB2 interacting proteins [endosome membrane] (Homo sapiens)
RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
TWF1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q12792 TWF1
Gene Names
TWF1, PTK9
Chain
initiator methionine:, chain:2-350
Reference Genes
BioGPS Gene:5756 TWF1
COSMIC (genes):TWF1 TWF1
CTD Gene:5756 TWF1
dbSNP Gene:5756 TWF1
ENSEMBL:ENSG00000151239 TWF1
HGNC:9620 TWF1
Monarch:5756 TWF1
NCBI Gene:5756 TWF1
OMIM:610932 TWF1
UCSC:Q12792 TWF1
Reference Transcript
RefSeq:NM_002822.4 TWF1
RefSeq:NM_001242397.1 TWF1
Other Identifiers
1064_at
11716945_s_at
11751302_a_at
11758185_s_at
16763390
201745_PM_at
201745_at
214007_PM_s_at
214007_s_at
3451709
3451710
3451711
3451712
3451713
3451714
3451715
3451716
3451717
3451718
3451719
3451720
3451721
3451722
3451723
3451724
3451725
3451727
3451728
3451729
3451730
3451731
3751447
3751449
3751450
3751451
3751452
3751453
3751454
3751455
3751456
4027784
4027785
4027786
5756
7962441
8013906
A_23_P48166
GE58856
GO:0003779
GO:0003785
GO:0005515
GO:0005524
GO:0005546
GO:0005737
GO:0005829
GO:0005856
GO:0005884
GO:0005911
GO:0005925
GO:0008092
GO:0008289
GO:0010591
GO:0010613
GO:0010976
GO:0015629
GO:0030016
GO:0030042
GO:0030175
GO:0030837
GO:0032587
GO:0032956
GO:0042989
GO:0043226
GO:0043538
GO:0044877
GO:0045296
GO:0048471
GO:0051015
GO:0051016
HMNXSV003057795
Hs.82643.1.S1_3p_a_at
ILMN_1681203
ILMN_1682675
ILMN_1734510
PH_hs_0029392
TC12001413.hg
U02680_at
g4506274_3p_at
Participates
as a candidate of
RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
as a component of
Stereocilium shaft [cytosol] (Homo sapiens)
Inferred To
twf [cytosol]
(Drosophila melanogaster)
TWF1 [cytosol]
(Bos taurus)
TWF1 [cytosol]
(Canis familiaris)
TWF1 [cytosol]
(Gallus gallus)
TWF1 [cytosol]
(Sus scrofa)
twf1 [cytosol]
(Xenopus tropicalis)
twfA [cytosol]
(Dictyostelium discoideum)
Twf1 [cytosol]
(Mus musculus)
Twf1 [cytosol]
(Rattus norvegicus)
Cross References
Guide to Pharmacology - Targets
2266
ENSEMBL
ENST00000395510
,
ENSP00000378886
,
ENST00000552521
,
ENSP00000448750
,
ENST00000548315
,
ENSP00000449428
OpenTargets
ENSG00000151239
HPA
ENSG00000151239-TWF1
PRO
Q12792
Pharos - Targets
Q12792
GlyGen
Q12792
PDB
7CCC
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P47756 CAPZB
1
CAPZB [cytosol]
(R-HSA-879409)
0.527
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
3
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