Reactome | TAPBP [endoplasmic reticulum-Golgi intermediate compartment membrane]

TAPBP [endoplasmic reticulum-Golgi intermediate compartment membrane]

Stable Identifier

R-HSA-8863976

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

Synonyms

Tapasin, TPSN_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O15533 TAPBP

Gene Names

TAPBP, NGS17, TAPA

Chain

signal peptide:1-20, chain:21-448

Reference Genes

BioGPS Gene:6892 TAPBP

COSMIC (genes):TAPBP TAPBP

CTD Gene:6892 TAPBP

dbSNP Gene:6892 TAPBP

ENSEMBL:ENSG00000231925 TAPBP

HGNC:11566 TAPBP

KEGG:hsa:6892 TAPBP

Monarch:6892 TAPBP

NCBI Gene:6892 TAPBP

OMIM:601962 TAPBP

UCSC:O15533 TAPBP

Reference Transcript

Other Identifiers

11735502_a_at

11751572_a_at

11756617_a_at

11756618_x_at

11757321_a_at

1555565_PM_s_at

1555565_s_at

17018215

17030026

17032710

17037511

17040221

208829_PM_at

208829_at

210294_PM_at

210294_at

213081_PM_at

213081_at

2950620

2950621

2950622

2950623

2950624

2950625

2950626

2950628

2950630

2950631

2950632

2950633

2950634

2950635

2950636

2950637

2950638

2950639

2950640

2950641

2950642

2950643

2950644

2950645

2950647

2950648

2950649

2950650

2950651

2950652

2950653

2950654

2950655

2950657

34178_at

41168_at

6892

74637_at

8125713

8178977

8180166

A_23_P259580

A_23_P315336

A_23_P360291

A_23_P365719

A_33_P3325914

GE54224

GE87404

GO:0000139

GO:0002376

GO:0002397

GO:0002398

GO:0002502

GO:0005515

GO:0005783

GO:0005789

GO:0006457

GO:0006890

GO:0010468

GO:0016020

GO:0016192

GO:0019885

GO:0023024

GO:0030670

GO:0033116

GO:0042288

GO:0042605

GO:0042824

GO:0043226

GO:0044183

GO:0046978

GO:0046979

GO:0050823

GO:0051082

GO:0060090

GO:0061635

GO:0061779

GO:0062061

GO:0065003

GO:0098553

HMNXSV003028171

HMNXSV003032577

HMNXSV003038859

Hs.206770.0.S2_3p_at

Hs2.370937.6.S1_3p_s_at

ILMN_1742450

ILMN_1773031

ILMN_1782851

PH_hs_0017822

TC06001584.hg

TC6_cox_hap2000208.hg

TC6_dbb_hap3000194.hg

TC6_mcf_hap5000183.hg

TC6_qbl_hap6000196.hg

g10803729_3p_at

g2587057_3p_at

Participates

as an output of

Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)

as an input of

SEC22B, CALR, STX4, TAP and TAPBP bind (Homo sapiens)

as a component of

CALR:SEC22B:STX4:TAP:TAPBP [phagocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

TAPBP [lumenal side of endoplasmic reticulum membrane]

TAPBP [phagocytic vesicle membrane]

Inferred To

Ghost homologue of TAPBP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)

tapbp.1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)

tapbp.2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)

Tapbp [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)

Tapbp [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)

Homologues of TAPBP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)

TAPBP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)

TAPBP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)

TAPBP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)

Cross References

RefSeq

NP_003181.3, NP_757346.2, NP_757345.2

ENSEMBL

ENSP00000514507, ENST00000699659, ENST00000395114, ENSP00000447665, ENST00000383198, ENST00000383197, ENSP00000419659, ENSP00000363700, ENSP00000407195, ENSP00000378546, ENSP00000372543, ENSP00000372684, ENSP00000372685, ENST00000374572, ENSP00000372542, ENSP00000404833, ENST00000489157, ENST00000456807, ENST00000383066, ENST00000434618, ENSP00000395701, ENSP00000402087, ENST00000551943, ENST00000383065, ENST00000417059, ENST00000426633

OpenTargets

ENSG00000231925

HPA

ENSG00000231925-TAPBP

PRO

O15533

Pharos - Targets

O15533

GlyGen

O15533

Orphanet

TAPBP

PDB

3F8U, 7QNG, 7TUG, 7QPD, 7TUF, 6ENY, 7TUE

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q03518 TAP1	3	TAP1 [endoplasmic reticulum membrane] (R-HSA-947474) TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863953) TAP1 [phagocytic vesicle membrane] (R-HSA-1236845)	0.803	13
UniProt:P01892 1A02			0.688	10
UniProt:Q03519 TAP2	3	TAP2 [endoplasmic reticulum membrane] (R-HSA-947475) TAP2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863947) TAP2 [phagocytic vesicle membrane] (R-HSA-1236821)	0.677	8
UniProt:P0C739 BNL2A			0.623	6
UniProt:Q77CE4 GN			0.564	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.527	9

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