Reactome | PSMD7 [secretory granule lumen]

PSMD7 [secretory granule lumen]

Stable Identifier

R-HSA-6801008

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

26S proteasome non-ATPase regulatory subunit 7, 26S proteasome regulatory subunit S12, Proteasome subunit p40, Mov34 protein homolog

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P51665 PSMD7

Gene Names

PSMD7, MOV34L

Chain

chain:1-324

Reference Genes

BioGPS Gene:5713 PSMD7

COSMIC (genes):PSMD7 PSMD7

CTD Gene:5713 PSMD7

dbSNP Gene:5713 PSMD7

ENSEMBL:ENSG00000103035.11 PSMD7

HGNC:9565 PSMD7

KEGG Gene (Homo sapiens):5713 PSMD7

Monarch:5713 PSMD7

NCBI Gene:5713 PSMD7

OMIM:157970 PSMD7

UCSC:P51665 PSMD7

Reference Transcript

RefSeq:NM_002811.4 PSMD7

Other Identifiers

0006840427

11729113_a_at

11729114_s_at

11746059_a_at

16821021

201705_PM_at

201705_at

3668618

3668619

3668625

3668626

3668627

3668628

3668629

3668631

3668634

3668635

3668636

3668637

3668638

3668639

3668640

40276_at

5713

7997230

945_at

A_14_P114737

A_23_P106741

D50063_at

GE57237

GO:0000502

GO:0005515

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005838

GO:0008233

GO:0008237

GO:0016020

GO:0016787

GO:0030163

GO:0031410

GO:0032991

GO:0034774

GO:0042803

GO:0043161

GO:0043226

GO:0070062

GO:0140096

GO:1904813

HMNXSV003019799

ILMN_1776173

PH_hs_0025797

TC16000612.hg

g4506230_3p_at

Participates

as a member of

Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)

Other forms of this molecule

PSMD7 [extracellular region]

PSMD7 [ficolin-1-rich granule lumen]

PSMD7 [nucleoplasm]

PSMD7 [cytosol]

Inferred To

Rpn8 [secretory granule lumen] (Drosophila melanogaster)

rpn-8 [secretory granule lumen] (Caenorhabditis elegans)

Psmd7 [secretory granule lumen] (Mus musculus)

Psmd7 [secretory granule lumen] (Rattus norvegicus)

PSMD7 [secretory granule lumen] (Bos taurus)

PSMD7 [secretory granule lumen] (Canis familiaris)

PSMD7 [secretory granule lumen] (Danio rerio)

PSMD7 [secretory granule lumen] (Gallus gallus)

PSMD7 [secretory granule lumen] (Plasmodium falciparum)

PSMD7 [secretory granule lumen] (Sus scrofa)

psmD7 [secretory granule lumen] (Dictyostelium discoideum)

psmd7 [secretory granule lumen] (Xenopus tropicalis)

rpn8 [secretory granule lumen] (Schizosaccharomyces pombe)

RPN8 [secretory granule lumen] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_002802.2

OpenTargets

ENSG00000103035

HPA

ENSG00000103035-PSMD7

GeneCards

P51665

Ensembl

ENST00000219313, ENSP00000219313, ENSG00000103035

PRO

P51665

Pharos - Targets

P51665

PDB

5T0J, 5VFS, 5GJR, 5VHI, 5VFT, 5GJQ, 5VFU, 2O96, 5VHF, 5VFQ, 5T0I, 6MSK, 5VHH, 5VFR, 5VHS, 6MSB, 5L4K, 5T0G, 6MSG, 6MSH, 6WJN, 5VFP, 5T0H, 6MSJ, 6WJD, 5T0C, 5M32, 6MSD, 5LN3, 5VGZ, 2O95

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.874	14
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.681	3
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.669	4
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.669	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272)	0.589	2
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	9

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