Reactome | PEX19 [cytosol]

PEX19 [cytosol]

Stable Identifier

R-HSA-3009036

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Peroxisomal biogenesis factor 19, PEX19_HUMAN

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External Reference Information

External Reference

UniProt:P40855 PEX19

Gene Names

PEX19, HK33, PXF, OK/SW-cl.22

Chain

initiator methionine:1, chain:2-296, propeptide:297-299

Reference Genes

BioGPS Gene:5824 PEX19

COSMIC (genes):PEX19 PEX19

CTD Gene:5824 PEX19

dbSNP Gene:5824 PEX19

ENSEMBL:ENSG00000162735 PEX19

ENSEMBL:ENSG00000162735.19 PEX19

HGNC:9713 PEX19

KEGG Gene (Homo sapiens):5824 PEX19

Monarch:5824 PEX19

NCBI Gene:5824 PEX19

OMIM:600279 PEX19

UCSC:P40855 PEX19

Reference Transcript

Other Identifiers

11732123_a_at

11732124_a_at

11733124_a_at

11733125_a_at

16695321

201706_PM_s_at

201706_s_at

201707_PM_at

201707_at

2440118

2440119

2440120

2440121

2440122

2440123

2440124

2440125

2440126

2440127

2440129

2440131

2440132

2440133

2440134

2440135

2440136

2440139

40471_at

5824

7921571

A_23_P160188

A_24_P19752

GE80865

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005777

GO:0005778

GO:0005829

GO:0005886

GO:0006457

GO:0006625

GO:0006886

GO:0007031

GO:0016020

GO:0016557

GO:0016559

GO:0031526

GO:0032991

GO:0033328

GO:0036105

GO:0043226

GO:0045046

GO:0050821

GO:0051117

GO:0061077

GO:0072663

GO:0140104

GO:0140597

GO:1900131

HMNXSV003023092

ILMN_1658759

PH_hs_0025832

TC01005889.hg

TC01006278.hg

X75535_at

g12653448_3p_a_at

g4506338_3p_at

Participates

as an output of

as an input of

as a component of

Inferred To

Pex19 [cytosol] (Drosophila melanogaster)

Pex19 [cytosol] (Mus musculus)

Pex19 [cytosol] (Rattus norvegicus)

prx-19 [cytosol] (Caenorhabditis elegans)

pex19 [cytosol] (Dictyostelium discoideum)

pex19 [cytosol] (Xenopus tropicalis)

PEX19 [cytosol] (Bos taurus)

PEX19 [cytosol] (Canis familiaris)

PEX19 [cytosol] (Danio rerio)

PEX19 [cytosol] (Gallus gallus)

PEX19 [cytosol] (Saccharomyces cerevisiae)

PEX19 [cytosol] (Schizosaccharomyces pombe)

PEX19 [cytosol] (Sus scrofa)

Modified Residues

Name

S-farnesyl-L-cysteine at 296

Coordinate

296

PsiMod Name

S-farnesyl-L-cysteine [MOD:00111]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine.

Cross References

RefSeq

NP_002848.1, NP_001180573.1

OpenTargets

ENSG00000162735

HPA

ENSG00000162735-PEX19

GeneCards

P40855

Ensembl

ENSG00000162735, ENST00000472750, ENST00000368072, ENSP00000434633, ENSP00000357051

PRO

P40855

Pharos - Targets

P40855

Orphanet

16643

PDB

2W85, 5LNF, 3AJB, 2WL8, 3MK4

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P56589 PEX3	2	PEX3 [cytosol] (R-HSA-9603792) PEX3 [peroxisomal membrane] (R-HSA-382608)	0.977	47
UniProt:O96011 PEX11B	2	PEX11B [peroxisomal membrane] (R-HSA-9625561) PEX11B [cytosol] (R-HSA-9625562)	0.946	22
UniProt:Q9Y5Y5 PEX16	2	PEX16 [peroxisomal membrane] (R-HSA-9603805) PEX16 [cytosol] (R-HSA-9603790)	0.933	20
UniProt:O75381 PEX14	2	PEX14 [cytosol] (R-HSA-9603806) PEX14 [peroxisomal membrane] (R-HSA-9033101)	0.922	26
UniProt:P23284 PPIB	2	PPIB [endoplasmic reticulum lumen] (R-HSA-1980262) PPIB [cytosol] (R-HSA-9728770)	0.718	6
UniProt:Q9NPF7 IL23A	2	IL23A [endoplasmic reticulum lumen] (R-HSA-8950224) IL23A [extracellular region] (R-HSA-447245)	0.718	6
UniProt:O43808 SLC25A17	2	SLC25A17 [cytosol] (R-HSA-9603781) SLC25A17 [peroxisomal membrane] (R-HSA-389642)	0.713	4
UniProt:Q92968 PEX13	2	PEX13 [cytosol] (R-HSA-9603795) PEX13 [peroxisomal membrane] (R-HSA-452790)	0.709	12
UniProt:Q9NR77 PXMP2	2	PXMP2 [cytosol] (R-HSA-9603794) PXMP2 [peroxisomal membrane] (R-HSA-8953432)	0.702	3
UniProt:Q7Z412 PEX26	2	PEX26 [cytosol] (R-HSA-9603779) PEX26 [peroxisomal membrane] (R-HSA-9033092)	0.683	9
UniProt:P28288 ABCD3	2	ABCD3 [cytosol] (R-HSA-1456459) ABCD3 [peroxisomal membrane] (R-HSA-1456468)	0.682	4
UniProt:A0A6A5PPQ8 A0A6A5PPQ8			0.556	3
UniProt:P51687 SUOX	1	SUOX [mitochondrial matrix] (R-HSA-1614570)	0.556	3
UniProt:P01574 IFNB1	1	IFNB1 [extracellular region] (R-HSA-877351)	0.556	3
UniProt:Q9UIG4 PS1C2			0.556	5
UniProt:Q9Y680 FKBP7			0.556	3
UniProt:O43521 BCL2L11	7	BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674) BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (R-HSA-6802276) BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol] (R-HSA-6802519) p-S69-BCL2L11 [cytosol] (R-HSA-2976671) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-BCL2L11 [cytosol] (R-HSA-140525) BCL2L11 [cytosol] (R-HSA-2976673)	0.556	3
UniProt:Q8N9F0 NAT8L	1	NAT8L [mitochondrial matrix] (R-HSA-8954477)	0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:O00623 PEX12	2	PEX12 [cytosol] (R-HSA-9603782) PEX12 [peroxisomal membrane] (R-HSA-8953911)	0.527	2
UniProt:Q96CS3 FAF2	3	FAF2 [cytosol] (R-HSA-6781921) FAF2 [extracellular region] (R-HSA-6806183) FAF2 [azurophil granule lumen] (R-HSA-6799138)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	4

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