Reactome | COPG1 [endoplasmic reticulum membrane]

COPG1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-6810960

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Coatomer gamma subunit

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        COPI vesicle uncoating at the ER (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo:NBAS:RINT1:ZW10:STX18:USE1L:BNIP1 [endoplasmic reticulum membrane] (Homo sapiens)
        
        coatomer [endoplasmic reticulum membrane] (Homo sapiens)
        
        tetrameric coatomer complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPG1,2 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPG1 [endoplasmic reticulum membrane] (Homo sapiens)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo:NBAS:RINT1:ZW10:STX18:USE1L:BNIP1 [endoplasmic reticulum membrane] (Homo sapiens)
        
        coatomer [endoplasmic reticulum membrane] (Homo sapiens)
        
        tetrameric coatomer complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPG1,2 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPG1 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y678 COPG1

Gene Names

COPG1, COPG

Chain

chain:1-874

Reference Genes

BioGPS Gene:22820 COPG1

COSMIC (genes):COPG1 COPG1

CTD Gene:22820 COPG1

dbSNP Gene:22820 COPG1

ENSEMBL:ENSG00000181789 COPG1

HGNC:2236 COPG1

KEGG Gene (Homo sapiens):22820 COPG1

Monarch:22820 COPG1

NCBI Gene:22820 COPG1

OMIM:615525 COPG1

UCSC:Q9Y678 COPG1

Reference Transcript

RefSeq:NM_016128.3 COPG1

Other Identifiers

0006350731

11716855_a_at

16945320

217749_at

22820

2641533

2641534

2641536

2641537

2641540

2641543

2641544

2641545

2641546

2641547

2641548

2641549

2641550

2641552

2641553

2641555

2641558

2641559

2641560

2641563

2641565

2641567

2641569

2641571

2641572

2641573

2641574

2641575

2641576

48785_at

48787_g_at

52810_at

8082478

A_14_P104366

A_23_P44617

GE55889

GO:0000139

GO:0003674

GO:0005198

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005783

GO:0005789

GO:0005793

GO:0005794

GO:0005829

GO:0006810

GO:0006886

GO:0006888

GO:0006890

GO:0006891

GO:0008150

GO:0009306

GO:0015031

GO:0016020

GO:0016192

GO:0030117

GO:0030126

GO:0030133

GO:0030663

GO:0030705

GO:0031410

GO:0032991

GO:0043226

GO:0051683

GO:0072384

HMNXSV003003676

ILMN_1708204

PH_hs_0032886

TC03000689.hg

g11559928_3p_at

g11559928_3p_x_at

Participates

as a member of

COPG1,2 [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

COPG1 [transport vesicle]

COPG1 [cytosol]

COPG1 [Golgi membrane]

Inferred To

copg2 [endoplasmic reticulum membrane] (Danio rerio)

COPG1 [endoplasmic reticulum membrane] (Canis familiaris)

COPG1 [endoplasmic reticulum membrane] (Gallus gallus)

COPG1 [endoplasmic reticulum membrane] (Plasmodium falciparum)

COPG1 [endoplasmic reticulum membrane] (Sus scrofa)

copG [endoplasmic reticulum membrane] (Dictyostelium discoideum)

copg-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

gammaCOP [endoplasmic reticulum membrane] (Drosophila melanogaster)

sec21 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

Copg1 [endoplasmic reticulum membrane] (Mus musculus)

Copg1 [endoplasmic reticulum membrane] (Rattus norvegicus)

SEC21 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

copg1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_057212.1

OpenTargets

ENSG00000181789

HPA

ENSG00000181789-COPG1

GeneCards

Q9Y678

Ensembl

ENSP00000325002, ENSG00000181789, ENST00000314797

PRO

Q9Y678

Pharos - Targets

Q9Y678

Orphanet

24430

GlyGen

Q9Y678

HMDB Protein

HMDBP08335

PDB

1R4X

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NTJ5 SACM1L	2	SACM1L [endoplasmic reticulum membrane] (R-HSA-1604637) SACM1L [Golgi membrane] (R-HSA-1806242)	0.576	3
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.564	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	9

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