Reactome | PXLP-K379-SPTLC2 [endoplasmic reticulum membrane]

PXLP-K379-SPTLC2 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-428146

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

SPTLC2, serine palmitoyltransferase 2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O15270 SPTLC2

Gene Names

SPTLC2, KIAA0526, LCB2

Chain

chain:1-562

Reference Genes

BioGPS Gene:9517 SPTLC2

COSMIC (genes):SPTLC2 SPTLC2

CTD Gene:9517 SPTLC2

dbSNP Gene:9517 SPTLC2

ENSEMBL:ENSG00000100596 SPTLC2

HGNC:11278 SPTLC2

KEGG:hsa:9517 SPTLC2

Monarch:9517 SPTLC2

NCBI Entrez Gene:9517 SPTLC2

OMIM:605713 SPTLC2

UCSC:O15270 SPTLC2

Reference Transcript

RefSeq:NM_004863.4 SPTLC2

Other Identifiers

11720645_at

11720646_at

11758838_at

16795192

203127_PM_s_at

203127_s_at

203128_PM_at

203128_at

216202_PM_s_at

216202_s_at

216203_PM_at

216203_at

225095_PM_at

225095_at

3573153

3573154

3573155

3573156

3573157

3573158

3573160

3573161

3573162

3573166

3573177

3573178

3573179

3573180

3573181

3573182

3573183

3573191

3573192

3573193

3573194

3573197

3573198

3573199

3573200

3573205

3573212

3573213

3573214

36518_at

63368_at

7980438

9517

A_23_P3146

A_24_P150486

GE53256

GE88612

GO:0004758

GO:0005515

GO:0005783

GO:0005789

GO:0006629

GO:0006665

GO:0006686

GO:0009058

GO:0016020

GO:0016740

GO:0016746

GO:0017059

GO:0030148

GO:0030170

GO:0046511

GO:0046512

GO:0046513

GO:0048856

GO:0060612

GO:1904504

HMNXSV003012274

Hs.315482.0.A1_3p_at

Hs.59403.1.S1_3p_at

ILMN_1704290

PH_hs_0003815

TC14001348.hg

TC14002098.hg

U15555_at

g13477298_3p_a_at

g4758667_3p_at

Participates

as a component of

PXLP-K-SPTLC1:PXLP-K379-SPTLC2:SPTSS [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

SPTLC2 [endoplasmic reticulum membrane] (Bos taurus)

SPTLC2 [endoplasmic reticulum membrane] (Gallus gallus)

SPTLC2 [endoplasmic reticulum membrane] (Sus scrofa)

Sptlc2 [endoplasmic reticulum membrane] (Mus musculus)

Sptlc2 [endoplasmic reticulum membrane] (Rattus norvegicus)

sptlc2a [endoplasmic reticulum membrane] (Danio rerio)

PXLP-K379-SPTLC2 [endoplasmic reticulum membrane] (Canis familiaris)

lace [endoplasmic reticulum membrane] (Drosophila melanogaster)

sptlc2 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Modified Residues

Name

N6-pyridoxal phosphate-L-lysine at 379

Coordinate

379

PsiMod Name

N6-pyridoxal phosphate-L-lysine [MOD:00128]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.

Cross References

RefSeq

NP_004854.1

Guide to Pharmacology - Targets

2510

OpenTargets

ENSG00000100596

ENSEMBL

ENSP00000216484, ENST00000216484, ENSG00000100596

ZINC - Substances

SPTC2_HUMAN

ZINC target

O15270

PRO

O15270

PDB

7YJ2, 7K0N, 7YJ1, 7CQK, 7K0L, 7YIY, 7CQI, 6M4N, 7K0P, 7K0I, 7YIU, 7K0Q, 7K0K, 7K0M, 7K0O, 6M4O, 7K0J

IntEnz

2.3.1.50

HPA

ENSG00000100596-SPTLC2

GeneCards

SPTLC2

Pharos - Targets

O15270

ZINC - Predictions - Purchasable

SPTC2_HUMAN

Orphanet

SPTLC2

HMDB Protein

HMDBP00888

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H1C4 UNC93B1	4	UNC93B1 [Golgi membrane] (R-HSA-1679064) UNC93B1 [endoplasmic reticulum membrane] (R-HSA-1678930) UNC93B1 P345Pfs103 [endoplasmic reticulum membrane] (R-HSA-9628866) UNC93B1 L230Afs188 [endoplasmic reticulum membrane] (R-HSA-9628869)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	9

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