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PXLP-K379-SPTLC2 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-428146
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
SPTLC2, serine palmitoyltransferase 2
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Sphingolipid de novo biosynthesis (Homo sapiens)
SPTLC complexes transfer acyl-CoA onto serine (Homo sapiens)
SPTLC complexes [endoplasmic reticulum membrane] (Homo sapiens)
PXLP-K-SPTLC1:PXLP-K379-SPTLC2:SPTSS [endoplasmic reticulum membrane] (Homo sapiens)
PXLP-K379-SPTLC2 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15270 SPTLC2
Gene Names
SPTLC2, KIAA0526, LCB2
Chain
chain:1-562
Reference Genes
BioGPS Gene:9517 SPTLC2
COSMIC (genes):SPTLC2 SPTLC2
CTD Gene:9517 SPTLC2
dbSNP Gene:9517 SPTLC2
ENSEMBL:ENSG00000100596 SPTLC2
ENSEMBL_homo_sapiens_GENE:ENSG00000100596.8 SPTLC2
HGNC:11278 SPTLC2
KEGG Gene (Homo sapiens):9517 SPTLC2
Monarch:9517 SPTLC2
NCBI Gene:9517 SPTLC2
OMIM:605713 SPTLC2
UCSC:O15270 SPTLC2
Reference Transcript
RefSeq:NM_004863.3 SPTLC2
Other Identifiers
11720645_at
11720646_at
11758838_at
16795192
203127_PM_s_at
203127_s_at
203128_PM_at
203128_at
216202_PM_s_at
216202_s_at
225095_PM_at
225095_at
3573153
3573154
3573155
3573156
3573157
3573158
3573160
3573161
3573178
3573181
3573182
3573191
3573194
3573197
3573198
3573200
3573205
3573212
3573213
3573214
63368_at
7980438
9517
A_23_P3146
A_24_P150486
GE53256
GE88612
GO:0003824
GO:0004758
GO:0005783
GO:0005789
GO:0006629
GO:0006665
GO:0006686
GO:0006914
GO:0009058
GO:0016020
GO:0016740
GO:0016746
GO:0017059
GO:0030148
GO:0030170
GO:0043226
GO:0046511
GO:0046512
GO:0046513
GO:0048856
GO:0060612
GO:1904504
HMNXSV003012274
Hs.315482.0.A1_3p_at
ILMN_1704290
PH_hs_0003815
TC14001348.hg
TC14002098.hg
g13477298_3p_a_at
g4758667_3p_at
Participates
as a component of
PXLP-K-SPTLC1:PXLP-K379-SPTLC2:SPTSS [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
SPTLC2 [endoplasmic reticulum membrane]
(Bos taurus)
SPTLC2 [endoplasmic reticulum membrane]
(Canis familiaris)
SPTLC2 [endoplasmic reticulum membrane]
(Gallus gallus)
SPTLC2 [endoplasmic reticulum membrane]
(Sus scrofa)
Sptlc2 [endoplasmic reticulum membrane]
(Mus musculus)
Sptlc2 [endoplasmic reticulum membrane]
(Rattus norvegicus)
sptlc2a [endoplasmic reticulum membrane]
(Danio rerio)
lace [endoplasmic reticulum membrane]
(Drosophila melanogaster)
sptlc2 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Modified Residues
Name
N6-pyridoxal phosphate-L-lysine at 379
Coordinate
379
PsiMod Name
N6-pyridoxal phosphate-L-lysine [MOD:00128]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.
Cross References
RefSeq
NP_004854.1
Guide to Pharmacology - Targets
2510
OpenTargets
ENSG00000100596
ZINC - Substances
SPTC2_HUMAN
ZINC target
O15270
PRO
O15270
PDB
7K0O
,
7K0K
,
7K0N
,
7YIU
,
7K0J
,
6M4O
,
6M4N
,
7K0I
,
7YJ1
,
7K0Q
,
7K0M
,
7YJ2
,
7CQK
,
7YIY
,
7CQI
,
7K0L
,
7K0P
IntEnz
2.3.1.50
HPA
ENSG00000100596-SPTLC2
GeneCards
O15270
Ensembl
ENST00000216484
,
ENSG00000100596
,
ENSP00000216484
Pharos - Targets
O15270
ZINC - Predictions - Purchasable
SPTC2_HUMAN
Orphanet
19488
HMDB Protein
HMDBP00888
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
9
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