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PPP3CA [cytosol]
Stable Identifier
R-HSA-201771
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform, P2BA_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Calcineurin activates NFAT (Homo sapiens)
Calcineurin binds NFATC1,2,3 (Homo sapiens)
Calcineurin (CaN) [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
Calcineurin:p-NFATC1,2,3 [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
Calcineurin dephosphorylates NFATC1,2,3 (Homo sapiens)
Calcineurin:p-NFATC1,2,3 [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A (Dectin-1) induces NFAT activation (Homo sapiens)
Activation of Calcineurin (Homo sapiens)
Calcineurin (CaN) [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Activation of Calcineurin (Homo sapiens)
Calcineurin (CaN) [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
Inactive catalytic PP2B is activated by the binding of calmodulin (Homo sapiens)
PP2B catalytic (Fe3+, Zn2+) [cytosol] (Homo sapiens)
PPP3CA,B,C [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
PPP3CA,B,C:Fe3+:Zn2+:4xCa2+:CaM [cytosol] (Homo sapiens)
PPP3CA,B,C [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
PPP3 complex dephosphorylates DARPP-32 on Thr34 (Homo sapiens)
PP2B catalytic (Fe3+, Zn2+) [cytosol] (Homo sapiens)
PPP3CA,B,C [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
PPP3 complex [cytosol] (Homo sapiens)
PPP3CA,B,C:Fe3+:Zn2+:4xCa2+:CaM [cytosol] (Homo sapiens)
PPP3CA,B,C [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
Activation of Calcineurin (Homo sapiens)
Calcineurin (CaN) [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
NFATC1:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
Translocation of NFATC1:CaN:CaM to nucleus (Homo sapiens)
NFATC1:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CA [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q08209 PPP3CA
Gene Names
PPP3CA, CALNA, CNA
Chain
initiator methionine:, chain:2-521
Reference Genes
BioGPS Gene:5530 PPP3CA
COSMIC (genes):PPP3CA PPP3CA
CTD Gene:5530 PPP3CA
dbSNP Gene:5530 PPP3CA
ENSEMBL:ENSG00000138814 PPP3CA
ENSEMBL_homo_sapiens_GENE:ENSG00000138814.17 PPP3CA
HGNC:9314 PPP3CA
KEGG Gene (Homo sapiens):5530 PPP3CA
Monarch:5530 PPP3CA
NCBI Gene:5530 PPP3CA
OMIM:114105 PPP3CA
UCSC:Q08209 PPP3CA
Reference Transcript
RefSeq:NM_000944.4 PPP3CA
RefSeq:NM_001130691.1 PPP3CA
RefSeq:NM_001130692.1 PPP3CA
Other Identifiers
11722847_s_at
11722848_a_at
11722849_a_at
11751254_a_at
16978387
202425_PM_x_at
202425_x_at
202429_PM_s_at
202429_s_at
202457_PM_s_at
202457_s_at
2779639
2779640
2779641
2779642
2779643
2779647
2779653
2779657
2779663
2779665
2779668
2779669
2779672
2779673
2779674
2779677
2779691
2779727
2779728
2779729
2779730
2779731
281_s_at
5530
65862_at
8101971
A_23_P92623
A_24_P414371
GE56877
GE80199
GO:0000082
GO:0000278
GO:0001975
GO:0002376
GO:0003012
GO:0003014
GO:0003824
GO:0004721
GO:0004722
GO:0004723
GO:0005509
GO:0005515
GO:0005516
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0005955
GO:0006351
GO:0006355
GO:0006470
GO:0006606
GO:0006816
GO:0006886
GO:0006913
GO:0007155
GO:0008287
GO:0008544
GO:0009898
GO:0010613
GO:0010628
GO:0010629
GO:0014883
GO:0014898
GO:0016018
GO:0016020
GO:0016192
GO:0016311
GO:0016787
GO:0017018
GO:0019722
GO:0019897
GO:0019899
GO:0022600
GO:0023052
GO:0023057
GO:0030018
GO:0030154
GO:0030216
GO:0030335
GO:0033173
GO:0033192
GO:0033555
GO:0035562
GO:0036057
GO:0036211
GO:0042060
GO:0042104
GO:0042110
GO:0042383
GO:0042995
GO:0043197
GO:0043226
GO:0043403
GO:0044877
GO:0045202
GO:0045669
GO:0045672
GO:0045785
GO:0045807
GO:0045944
GO:0046676
GO:0046872
GO:0046878
GO:0046983
GO:0048741
GO:0048813
GO:0048856
GO:0048870
GO:0050774
GO:0050804
GO:0050877
GO:0051091
GO:0051117
GO:0051592
GO:0055085
GO:0060079
GO:0061006
GO:0070262
GO:0070886
GO:0071333
GO:0090193
GO:0097205
GO:0097720
GO:0098685
GO:0098772
GO:0098794
GO:0098978
GO:0099170
GO:0140096
GO:0140677
GO:1901386
GO:1901387
GO:1903244
GO:1905205
GO:1905665
GO:1905949
HMNXSV003043576
Hs.272458.0.S2_3p_a_at
ILMN_1670970
ILMN_2044226
L14778_s_at
PH_hs_0014077
TC04001425.hg
g6715567_3p_a_at
g7669991_3p_a_at
Participates
as a member of
PPP3CA,B,C [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
Other forms of this molecule
PPP3CA [nucleoplasm]
Inferred To
PPP3CA [cytosol]
(Caenorhabditis elegans)
PPP3CA [cytosol]
(Canis familiaris)
PPP3CA [cytosol]
(Dictyostelium discoideum)
PPP3CA [cytosol]
(Drosophila melanogaster)
PPP3CA [cytosol]
(Gallus gallus)
PPP3CA [cytosol]
(Plasmodium falciparum)
PPP3CA [cytosol]
(Saccharomyces cerevisiae)
PPP3CA [cytosol]
(Schizosaccharomyces pombe)
PPP3CA [cytosol]
(Sus scrofa)
Ppp3ca [cytosol]
(Mus musculus)
Ppp3ca [cytosol]
(Rattus norvegicus)
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [cytosol]
(Bos taurus)
Cross References
RefSeq
NP_001124163.1
,
NP_001124164.1
,
NP_000935.1
OpenTargets
ENSG00000138814
GeneCards
Q08209
HPA
ENSG00000138814-PPP3CA
ZINC target
Q08209
Ensembl
ENSP00000378322
,
ENST00000323055
,
ENSG00000138814
,
ENSP00000422781
,
ENSP00000378323
,
ENST00000394854
,
ENST00000394853
,
ENST00000512215
,
ENSP00000320580
PRO
Q08209
Pharos - Targets
Q08209
Orphanet
26038
HMDB Protein
HMDBP07948
PDB
1MF8
,
3LL8
,
1M63
,
6UUQ
,
2JZI
,
6NUF
,
5SVE
,
4F0Z
,
2P6B
,
6NUU
,
6NUC
,
5C1V
,
4Q5U
,
1AUI
,
2JOG
,
2W73
,
2R28
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.678
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
10
UniProt:P54578 USP14
1
USP14 [cytosol]
(R-HSA-5689541)
0.463
3
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