Reactome | IARS [cytosol]

IARS [cytosol]

Stable Identifier

R-HSA-379641

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Isoleucyl-tRNA synthetase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P41252 IARS1

Gene Names

IARS1, IARS

Chain

chain:1-1262

Reference Genes

BioGPS Gene:3376 IARS1

CTD Gene:3376 IARS1

dbSNP Gene:3376 IARS1

ENSEMBL:ENSG00000196305 IARS

ENSEMBL_homo_sapiens_GENE:ENSG00000196305.19 IARS1

ENSEMBL_homo_sapiens_GENE:ENSG00000291356.1 IARS1

HGNC:5330 IARS1

KEGG Gene (Homo sapiens):3376 IARS1

Monarch:3376 IARS1

NCBI Gene:3376 IARS1

OMIM:600709 IARS1

UCSC:P41252 IARS1

Reference Transcript

Other Identifiers

11715505_a_at

11750569_a_at

11751966_a_at

11752128_a_at

17095775

204744_PM_s_at

204744_s_at

2590651

3214669

3214670

3214671

3214673

3214674

3214675

3214679

3214680

3214689

3214690

3214692

3214694

3214695

3214697

3214699

3214701

3214704

3214706

3214708

3214709

3214713

3214714

3214715

3214716

3214718

3214719

3214720

3214721

3214723

3214724

3214726

3214727

3214728

3214730

3214733

3214735

3214736

3214738

3214739

3214744

3214745

3214746

3214747

3214748

3278248

3376

40827_at

8162313

A_23_P258964

A_33_P3209346

A_33_P3209351

D28473_s_at

GE57146

GO:0000049

GO:0000166

GO:0001649

GO:0002161

GO:0003723

GO:0003824

GO:0004812

GO:0004822

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006399

GO:0006412

GO:0006418

GO:0006428

GO:0006520

GO:0016020

GO:0016787

GO:0016874

GO:0017101

GO:0030154

GO:0043226

GO:0051020

GO:0070062

GO:0106074

GO:0140098

HMNXSV003014267

ILMN_1733956

ILMN_1801639

PH_hs_0010344

TC09001331.hg

g7770071_3p_a_at

Participates

as a component of

Inferred To

IleRS [cytosol] (Drosophila melanogaster)

Iars1 [cytosol] (Rattus norvegicus)

IARS1 [cytosol] (Bos taurus)

IARS1 [cytosol] (Canis familiaris)

IARS1 [cytosol] (Sus scrofa)

IARS [cytosol] (Dictyostelium discoideum)

IARS [cytosol] (Gallus gallus)

IARS [cytosol] (Mus musculus)

Cross References

RefSeq

NP_038203.2, NP_002152.2

ZINC - World Drugs

SYIC_HUMAN

OpenTargets

ENSG00000196305

ZINC - FDA approved

SYIC_HUMAN

ZINC - Substances

SYIC_HUMAN

ZINC target

P41252

ZINC - Biogenic

SYIC_HUMAN

PRO

P41252

HPA

ENSG00000196305-IARS1

GeneCards

P41252

Ensembl

ENST00000443024, ENST00000375643, ENSG00000196305, ENSP00000364794, ENSP00000406448, ENST00000683565, ENSP00000507144

Pharos - Targets

P41252

Orphanet

25185

ZINC - Predictions - Purchasable

SYIC_HUMAN

HMDB Protein

HMDBP00614

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.527	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	9
UniProt:P05412 JUN	4	p-S63,S73-JUN [cytosol] (R-HSA-8868682) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194)	0.462	3

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