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IARS [cytosol]
Stable Identifier
R-HSA-379641
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Isoleucyl-tRNA synthetase
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
MAPK-dependent phosphorylation of KARS (Homo sapiens)
KARS-depleted MSC [cytosol] (Homo sapiens)
IARS [cytosol] (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
IARS [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Selenoamino acid metabolism (Homo sapiens)
tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
IARS [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
tRNA Aminoacylation (Homo sapiens)
Cytosolic tRNA aminoacylation (Homo sapiens)
arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
IARS [cytosol] (Homo sapiens)
aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
IARS [cytosol] (Homo sapiens)
glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
IARS [cytosol] (Homo sapiens)
glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
IARS [cytosol] (Homo sapiens)
isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate (Homo sapiens)
IARS [cytosol] (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
IARS [cytosol] (Homo sapiens)
leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
IARS [cytosol] (Homo sapiens)
lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
IARS [cytosol] (Homo sapiens)
methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
IARS [cytosol] (Homo sapiens)
proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
IARS [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P41252 IARS1
Gene Names
IARS1, IARS
Chain
chain:1-1262
Reference Genes
BioGPS Gene:3376 IARS1
COSMIC (genes):IARS IARS1
CTD Gene:3376 IARS1
dbSNP Gene:3376 IARS1
ENSEMBL:ENSG00000196305 IARS1
HGNC:5330 IARS1
KEGG:hsa:3376 IARS1
Monarch:3376 IARS1
NCBI Gene:3376 IARS1
OMIM:600709 IARS1
UCSC:P41252 IARS1
Reference Transcript
RefSeq:NM_013417.4 IARS1
RefSeq:NM_001378575.1 IARS1
RefSeq:NM_001378574.1 IARS1
RefSeq:NM_001378576.1 IARS1
RefSeq:NM_001378573.1 IARS1
RefSeq:NM_002161.6 IARS1
Other Identifiers
11715505_a_at
11750569_a_at
11751966_a_at
11752128_a_at
17095775
204744_PM_s_at
204744_s_at
238922_PM_at
238922_at
239794_PM_at
239794_at
2590651
3214669
3214670
3214671
3214673
3214674
3214675
3214676
3214677
3214679
3214680
3214681
3214685
3214686
3214687
3214688
3214689
3214690
3214691
3214692
3214693
3214694
3214695
3214697
3214698
3214699
3214700
3214701
3214702
3214703
3214704
3214705
3214706
3214707
3214708
3214709
3214710
3214711
3214712
3214713
3214714
3214715
3214716
3214718
3214719
3214720
3214721
3214723
3214724
3214726
3214727
3214728
3214730
3214731
3214732
3214733
3214734
3214735
3214736
3214737
3214738
3214739
3214744
3214745
3214746
3214747
3214748
3278248
3376
40827_at
70428_at
79464_at
8162313
81666_at
83529_at
A_23_P258964
A_33_P3209346
A_33_P3209351
D28473_s_at
GE57146
GE653180
GO:0000049
GO:0000166
GO:0001649
GO:0002161
GO:0003723
GO:0003824
GO:0004812
GO:0004822
GO:0005515
GO:0005524
GO:0005654
GO:0005737
GO:0005829
GO:0006399
GO:0006412
GO:0006418
GO:0006428
GO:0006520
GO:0016020
GO:0016787
GO:0016874
GO:0017101
GO:0030154
GO:0051020
GO:0070062
GO:0106074
GO:0140098
HMNXSV003014267
Hs.122517.0.A1_3p_at
Hs.157556.0.A1_3p_at
ILMN_1733956
ILMN_1801639
PH_hs_0010344
TC09001331.hg
g7770071_3p_a_at
Participates
as a component of
KARS-depleted MSC [cytosol] (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
Inferred To
IleRS [cytosol]
(Drosophila melanogaster)
Iars1 [cytosol]
(Mus musculus)
Iars1 [cytosol]
(Rattus norvegicus)
IARS1 [cytosol]
(Canis familiaris)
IARS1 [cytosol]
(Sus scrofa)
ileS [cytosol]
(Dictyostelium discoideum)
IARS [cytosol]
(Bos taurus)
IARS [cytosol]
(Gallus gallus)
Cross References
RefSeq
NP_001365502.1
,
NP_002152.2
,
NP_001365504.1
,
NP_038203.2
,
NP_001365503.1
,
NP_001365505.1
ZINC - World Drugs
SYIC_HUMAN
OpenTargets
ENSG00000196305
ENSEMBL
ENST00000707251
,
ENSP00000516810
,
ENST00000443024
,
ENSG00000291356
,
ENST00000375643
,
ENSP00000507144
,
ENSP00000516808
,
ENSP00000516807
,
ENST00000707249
,
ENSP00000364794
,
ENST00000707248
,
ENSP00000406448
,
ENST00000683565
,
ENSG00000196305
ZINC - FDA approved
SYIC_HUMAN
ZINC - Substances
SYIC_HUMAN
ZINC - Biogenic
SYIC_HUMAN
ZINC target
P41252
PRO
P41252
GlyGen
P41252
HPA
ENSG00000196305-IARS1
GeneCards
IARS1
Pharos - Targets
P41252
Orphanet
IARS1
ZINC - Predictions - Purchasable
SYIC_HUMAN
HMDB Protein
HMDBP00614
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P47897 QARS1
2
QARS [cytosol]
(R-HSA-379615)
QARS [mitochondrial matrix]
(R-HSA-379592)
0.527
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
0.483
9
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.462
3
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