Reactome | SAE1 [nucleoplasm]

SAE1 [nucleoplasm]

Stable Identifier

R-HSA-947697

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SUMO-activating enzyme subunit 1, SAE1_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
11481243	Expression and regulation of the mammalian SUMO-1 E1 enzyme Cavenagh, MM, Azuma, Y, Tan, SH, Saitoh, H, Ainsztein, AM, Dasso, M	FASEB J.	2001

External Reference Information

External Reference

UniProt:Q9UBE0 SAE1

Gene Names

SAE1, AOS1, SUA1, UBLE1A

Chain

chain:1-346, initiator methionine:, chain:2-346

Reference Genes

BioGPS Gene:10055 SAE1

COSMIC (genes):SAE1 SAE1

CTD Gene:10055 SAE1

dbSNP Gene:10055 SAE1

ENSEMBL:ENSG00000142230 SAE1

HGNC:30660 SAE1

KEGG:hsa:10055 SAE1

Monarch:10055 SAE1

NCBI Gene:10055 SAE1

OMIM:613294 SAE1

UCSC:Q9UBE0 SAE1

Reference Transcript

Other Identifiers

10055

11737533_a_at

11744108_x_at

11751729_a_at

11751730_x_at

1555618_PM_s_at

1555618_s_at

16863551

217946_PM_s_at

217946_s_at

3353524

3353529

3837133

3837134

3837137

3837138

3837140

3837141

3837142

3837143

3837144

3837145

3837146

3837147

3837148

3837149

3837150

3837151

3837152

3837159

3837162

3837164

3837167

3837168

3837169

3837170

3837171

3837172

3837173

3837174

3837175

3837176

3837178

3837181

45712_at

51084_at

8029884

A_14_P101357

A_23_P16337

A_24_P194000

GE61854

GO:0003824

GO:0004839

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0008047

GO:0008641

GO:0016567

GO:0016874

GO:0016925

GO:0019948

GO:0031510

GO:0032446

GO:0033235

GO:0036211

GO:0043008

GO:0043226

GO:0044388

GO:0046982

GO:0098772

GO:0140096

GO:0140657

GO:1903955

HMNXSV003025211

HMNXSV003025778

Hs2.279868.2.S1_3p_s_at

ILMN_1657204

PH_hs_0022094

TC19000672.hg

TC19002180.hg

g7705472_3p_s_at

Participates

as a component of

Inferred To

Aos1 [nucleoplasm] (Drosophila melanogaster)

rad31 [nucleoplasm] (Schizosaccharomyces pombe)

Sae1 [nucleoplasm] (Mus musculus)

Sae1 [nucleoplasm] (Rattus norvegicus)

AOS1 [nucleoplasm] (Saccharomyces cerevisiae)

sae1 [nucleoplasm] (Danio rerio)

sae1 [nucleoplasm] (Dictyostelium discoideum)

sae1 [nucleoplasm] (Xenopus tropicalis)

aos-1 [nucleoplasm] (Caenorhabditis elegans)

SAE1 [nucleoplasm] (Bos taurus)

SAE1 [nucleoplasm] (Canis familiaris)

SAE1 [nucleoplasm] (Gallus gallus)

SAE1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_005491.1, NP_001139186.1, NP_001139185.1

OpenTargets

ENSG00000142230

ENSEMBL

ENSP00000416557, ENST00000270225, ENST00000413379, ENSP00000440818, ENST00000392776, ENSP00000270225

ZINC - Substances

SAE1_HUMAN

ZINC - Biogenic

SAE1_HUMAN

ZINC target

Q9UBE0

PRO

Q9UBE0

GlyGen

Q9UBE0

PDB

6XOI, 6XOH, 6XOG, 3KYD, 3KYC, 6CWZ, 6CWY, 1Y8Q, 1Y8R

ZINC - Metabolites

SAE1_HUMAN

HPA

ENSG00000142230-SAE1

Pharos - Targets

Q9UBE0

ZINC - Predictions - Purchasable

SAE1_HUMAN

HMDB Protein

HMDBP11566

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342)	0.802	6
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.734	4
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3
UniProt:Q06710 PAX8	1	PAX8 [nucleoplasm] (R-HSA-3968418)	0.556	3
UniProt:Q02548 PAX5	1	PAX5 [nucleoplasm] (R-HSA-158583)	0.556	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	11

Cite Us!